bisacodyl-4616 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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193 genes differentially expressed following the bisacodyl-4616 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIF1 allograft inflammatory factor 1
ANKRD12 ankyrin repeat domain 12
ATF3 activating transcription factor 3
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
C10ORF12 chromosome 10 open reading frame 12
CA4 carbonic anhydrase IV
CCDC85C coiled-coil domain containing 85C
CCL13 chemokine (C-C motif) ligand 13
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDH8 cadherin 8, type 2
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CMA1 chymase 1, mast cell
COL3A1 collagen, type III, alpha 1
COMT catechol-O-methyltransferase
CRYBB1 crystallin, beta B1
CSN2 casein beta
CTSE cathepsin E
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
CYSLTR1 cysteinyl leukotriene receptor 1
DDIT4 DNA-damage-inducible transcript 4
DRP2 dystrophin related protein 2
DSC1 desmocollin 1
EGR1 early growth response 1
EGR2 early growth response 2
ELSPBP1 epididymal sperm binding protein 1
EPHA7 EPH receptor A7
F2RL2 coagulation factor II (thrombin) receptor-like 2
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FGF18 fibroblast growth factor 18
FOS FBJ murine osteosarcoma viral oncogene homolog
FRMD4B FERM domain containing 4B
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GEM GTP binding protein overexpressed in skeletal muscle
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GRM4 glutamate receptor, metabotropic 4
GTPBP1 GTP binding protein 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IHH indian hedgehog
IL11 interleukin 11
IL6 interleukin 6
KANSL3 KAT8 regulatory NSL complex subunit 3
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4
KLHL25 kelch-like family member 25
LINC00652 long intergenic non-protein coding RNA 652
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K7 mitogen-activated protein kinase kinase 7
MBNL1 muscleblind-like splicing regulator 1
MFAP5 microfibrillar associated protein 5
MORN1 MORN repeat containing 1
MSR1 macrophage scavenger receptor 1
N4BP2L2 NEDD4 binding protein 2-like 2
NCLN nicalin
NCR1 natural cytotoxicity triggering receptor 1
NEUROG1 neurogenin 1
NF1 neurofibromin 1
OTOF otoferlin
PADI4 peptidyl arginine deiminase, type IV
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFB platelet-derived growth factor beta polypeptide
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRR protein tyrosine phosphatase, receptor type, R
RBP3 retinol binding protein 3, interstitial
RGS12 regulator of G-protein signaling 12
RS1 retinoschisin 1
RUNX1 runt-related transcription factor 1
SAMD4A sterile alpha motif domain containing 4A
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIGLEC8 sialic acid binding Ig-like lectin 8
SLA Src-like-adaptor
SLMO1 slowmo homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPINK5 serine peptidase inhibitor, Kazal type 5
STC2 stanniocalcin 2
STRN3 striatin, calmodulin binding protein 3
SYT5 synaptotagmin V
TGFB2 transforming growth factor, beta 2
THPO thrombopoietin
TMEM19 transmembrane protein 19
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRD T cell receptor delta locus
TSSK2 testis-specific serine kinase 2
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
VGF VGF nerve growth factor inducible
VSIG4 V-set and immunoglobulin domain containing 4
WNT3 wingless-type MMTV integration site family, member 3
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGAP24 Rho GTPase activating protein 24
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ASB13 ankyrin repeat and SOCS box containing 13
C14ORF169 chromosome 14 open reading frame 169
C9ORF91 chromosome 9 open reading frame 91
CBR3 carbonyl reductase 3
CCNA1 cyclin A1
CEP70 centrosomal protein 70kDa
CHEK2 checkpoint kinase 2
CHMP7 charged multivesicular body protein 7
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPA4 carboxypeptidase A4
CTSO cathepsin O
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DOLK dolichol kinase
EPHX2 epoxide hydrolase 2, cytoplasmic
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM169A family with sequence similarity 169, member A
FAM50B family with sequence similarity 50, member B
FZD3 frizzled class receptor 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP3 glucuronidase, beta pseudogene 3
HAUS6 HAUS augmin-like complex, subunit 6
HMHA1 histocompatibility (minor) HA-1
HPS6 Hermansky-Pudlak syndrome 6
ICE2 interactor of little elongation complex ELL subunit 2
INPP5F inositol polyphosphate-5-phosphatase F
IRF1 interferon regulatory factor 1
KATNBL1 katanin p80 subunit B-like 1
KIAA0753 KIAA0753
KIAA1462 KIAA1462
KRCC1 lysine-rich coiled-coil 1
LMNB1 lamin B1
LOC100272216 uncharacterized LOC100272216
MAGEH1 melanoma antigen family H1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MBTD1 mbt domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MEIS3P1 Meis homeobox 3 pseudogene 1
MITF microphthalmia-associated transcription factor
MUM1 melanoma associated antigen (mutated) 1
MUTYH mutY homolog
NDP Norrie disease (pseudoglioma)
NDRG4 NDRG family member 4
NHLRC2 NHL repeat containing 2
NLRX1 NLR family member X1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAIP2B poly(A) binding protein interacting protein 2B
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PCYOX1L prenylcysteine oxidase 1 like
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRR15L proline rich 15-like
PRR7 proline rich 7 (synaptic)
PTK6 protein tyrosine kinase 6
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RANBP17 RAN binding protein 17
RINT1 RAD50 interactor 1
SALL2 spalt-like transcription factor 2
SAYSD1 SAYSVFN motif domain containing 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SH2D4A SH2 domain containing 4A
SHROOM2 shroom family member 2
SLITRK5 SLIT and NTRK-like family, member 5
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAC SH3 and cysteine rich domain
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TGDS TDP-glucose 4,6-dehydratase
TGS1 trimethylguanosine synthase 1
TMEM132A transmembrane protein 132A
TMEM177 transmembrane protein 177
TRIM68 tripartite motif containing 68
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
UNC119 unc-119 homolog (C. elegans)
YY2 YY2 transcription factor
ZNF177 zinc finger protein 177
ZNF204P zinc finger protein 204, pseudogene
ZNF239 zinc finger protein 239
ZNF274 zinc finger protein 274
ZNF276 zinc finger protein 276
ZNF365 zinc finger protein 365
ZNF629 zinc finger protein 629
ZNF696 zinc finger protein 696
ZNF7 zinc finger protein 7
ZNF839 zinc finger protein 839
ZXDC ZXD family zinc finger C