bipolar disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A mood disorder that involves alternating periods of mania and depression. (Human Disease Ontology, DOID_3312)
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Genes

211 genes co-occuring with the disease bipolar disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
BPI bactericidal/permeability-increasing protein 2.54787
GADL1 glutamate decarboxylase-like 1 2.18765
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.52864
MAATS1 MYCBP-associated, testis expressed 1 1.46891
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.43552
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 1.41402
BDNF brain-derived neurotrophic factor 1.29047
DEFB107B defensin, beta 107B 1.27824
PCDHB4 protocadherin beta 4 1.26386
CDH12 cadherin 12, type 2 (N-cadherin 2) 1.2508
DEFB1 defensin, beta 1 1.20007
NPEPPS aminopeptidase puromycin sensitive 1.19186
SYT4 synaptotagmin IV 1.17164
DTNBP1 dystrobrevin binding protein 1 1.12108
PCDH12 protocadherin 12 1.07824
CDH18 cadherin 18, type 2 1.07572
COMT catechol-O-methyltransferase 1.0711
KATNB1 katanin p80 (WD repeat containing) subunit B 1 1.04798
GSK3B glycogen synthase kinase 3 beta 0.99233
CDH10 cadherin 10, type 2 (T2-cadherin) 0.955779
CCBL2 cysteine conjugate-beta lyase 2 0.95369
TUBA8 tubulin, alpha 8 0.946186
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.914315
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 0.908965
ALG9 ALG9, alpha-1,2-mannosyltransferase 0.907731
NRG1 neuregulin 1 0.902799
INPP1 inositol polyphosphate-1-phosphatase 0.898693
CLOCK clock circadian regulator 0.888848
RGS4 regulator of G-protein signaling 4 0.876557
GRID1 glutamate receptor, ionotropic, delta 1 0.852402
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 0.848716
TPH2 tryptophan hydroxylase 2 0.834788
CDH9 cadherin 9, type 2 (T1-cadherin) 0.831099
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.818796
CRH corticotropin releasing hormone 0.811001
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 0.806488
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 0.804846
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 0.804026
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 0.798692
ADARB1 adenosine deaminase, RNA-specific, B1 0.797872
RORB RAR-related orphan receptor B 0.786803
GRIK3 glutamate receptor, ionotropic, kainate 3 0.781888
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 0.774114
CINP cyclin-dependent kinase 2 interacting protein 0.770435
CDH8 cadherin 8, type 2 0.767985
KCTD12 potassium channel tetramerization domain containing 12 0.756971
MAOA monoamine oxidase A 0.754934
EPHA6 EPH receptor A6 0.748424
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.740705
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.737865
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 0.73746
NTF4 neurotrophin 4 0.733406
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.733406
HPS6 Hermansky-Pudlak syndrome 6 0.720461
DRD2 dopamine receptor D2 0.716425
PTPN7 protein tyrosine phosphatase, non-receptor type 7 0.713198
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.711183
EGR3 early growth response 3 0.695905
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.694301
KAT6B K(lysine) acetyltransferase 6B 0.691495
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 0.691495
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 0.686691
TRH thyrotropin-releasing hormone 0.686291
TSNAX translin-associated factor X 0.679898
DEAF1 DEAF1 transcription factor 0.678302
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.674713
MFGE8 milk fat globule-EGF factor 8 protein 0.666755
CHD1L chromodomain helicase DNA binding protein 1-like 0.662784
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.653671
DAO D-amino-acid oxidase 0.648138
DRD3 dopamine receptor D3 0.646559
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.637495
SRPX2 sushi-repeat containing protein, X-linked 2 0.62885
SNAP25 synaptosomal-associated protein, 25kDa 0.614356
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.608885
PURA purine-rich element binding protein A 0.608104
MARCKS myristoylated alanine-rich protein kinase C substrate 0.606152
DPYSL3 dihydropyrimidinase-like 3 0.59952
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.592895
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.589001
ANKK1 ankyrin repeat and kinase domain containing 1 0.589001
EGR4 early growth response 4 0.581217
DISC1 disrupted in schizophrenia 1 0.572273
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.55945
SULT4A1 sulfotransferase family 4A, member 1 0.547032
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.529222
MAOB monoamine oxidase B 0.528449
NRXN3 neurexin 3 0.527676
AUTS2 autism susceptibility candidate 2 0.526518
AK2 adenylate kinase 2 0.52343
PRG4 proteoglycan 4 0.522273
SP8 Sp8 transcription factor 0.521888
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.51842
LDB1 LIM domain binding 1 0.514186
CRHBP corticotropin releasing hormone binding protein 0.508424
PCDH10 protocadherin 10 0.505356
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.500379
SRCIN1 SRC kinase signaling inhibitor 1 0.498849
CARS cysteinyl-tRNA synthetase 0.498085
UBD ubiquitin D 0.494648
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 0.481325
AMY1B amylase, alpha 1B (salivary) 0.474119
AMY1C amylase, alpha 1C (salivary) 0.474119
AMY1A amylase, alpha 1A (salivary) 0.474119
NPAS2 neuronal PAS domain protein 2 0.473361
XG Xg blood group 0.471846
PIR pirin (iron-binding nuclear protein) 0.470332
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.466928
KIF1A kinesin family member 1A 0.465416
DRD1 dopamine receptor D1 0.462772
DIO1 deiodinase, iodothyronine, type I 0.459751
POMC proopiomelanocortin 0.458996
PTPRG protein tyrosine phosphatase, receptor type, G 0.453716
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.451831
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 0.451078
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.451078
MIER1 mesoderm induction early response 1, transcriptional regulator 0.449571
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 0.445052
IL2RB interleukin 2 receptor, beta 0.444676
PER2 period circadian clock 2 0.441666
RAP1GAP RAP1 GTPase activating protein 0.440538
GRM3 glutamate receptor, metabotropic 3 0.43941
DAOA D-amino acid oxidase activator 0.43753
AANAT aralkylamine N-acetyltransferase 0.43753
PER1 period circadian clock 1 0.435651
GSK3A glycogen synthase kinase 3 alpha 0.43227
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.431144
DRD4 dopamine receptor D4 0.430768
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.427765
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.42589
EEF2 eukaryotic translation elongation factor 2 0.416521
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.410535
BSN bassoon presynaptic cytomatrix protein 0.408666
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.394118
HOMER1 homer scaffolding protein 1 0.384822
ZNF436 zinc finger protein 436 0.380368
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.379256
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.377773
GRM4 glutamate receptor, metabotropic 4 0.367779
PCNT pericentrin 0.366671
NGF nerve growth factor (beta polypeptide) 0.366671
HRH1 histamine receptor H1 0.362609
OXT oxytocin/neurophysin I prepropeptide 0.357077
CRY1 cryptochrome circadian clock 1 0.349717
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.347511
PGRMC1 progesterone receptor membrane component 1 0.343473
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.33651
STYK1 serine/threonine/tyrosine kinase 1 0.332121
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.332121
NRCAM neuronal cell adhesion molecule 0.323002
PNP purine nucleoside phosphorylase 0.321181
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 0.314278
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.30631
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.302337
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 0.301254
VIT vitrin 0.295132
BCO1 beta-carotene oxygenase 1 0.294772
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.293694
DPYSL2 dihydropyrimidinase-like 2 0.292257
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.291898
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.29118
CRP C-reactive protein, pentraxin-related 0.269753
AGPS alkylglycerone phosphate synthase 0.268687
FGA fibrinogen alpha chain 0.266558
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.262306
NSF N-ethylmaleimide-sensitive factor 0.254536
ATXN7 ataxin 7 0.253127
S100B S100 calcium binding protein B 0.250311
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 0.246799
MID2 midline 2 0.246448
B3GAT2 beta-1,3-glucuronyltransferase 2 0.237357
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.23492
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.234225
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.233878
PER3 period circadian clock 3 0.230409
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.226262
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.225229
HEXA hexosaminidase A (alpha polypeptide) 0.22454
FADS1 fatty acid desaturase 1 0.221793
PRODH proline dehydrogenase (oxidase) 1 0.215992
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.214975
MIXL1 Mix paired-like homeobox 0.203604
EGR2 early growth response 2 0.201308
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.199681
PNPLA2 patatin-like phospholipase domain containing 2 0.196139
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.192031
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.18591
GPR162 G protein-coupled receptor 162 0.183835
PNOC prepronociceptin 0.183835
TP73 tumor protein p73 0.176485
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.174617
PADI4 peptidyl arginine deiminase, type IV 0.172544
FBP1 fructose-1,6-bisphosphatase 1 0.172291
NCR3 natural cytotoxicity triggering receptor 3 0.171535
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.168148
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.164571
CDH13 cadherin 13 0.164149
MMP12 matrix metallopeptidase 12 0.161011
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 0.140316
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.140081
KAT5 K(lysine) acetyltransferase 5 0.139328
IVD isovaleryl-CoA dehydrogenase 0.1387
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.138412
HRAS Harvey rat sarcoma viral oncogene homolog 0.137341
POLG polymerase (DNA directed), gamma 0.137296
IARS isoleucyl-tRNA synthetase 0.137034
CCL2 chemokine (C-C motif) ligand 2 0.137034
CRYZ crystallin, zeta (quinone reductase) 0.136514
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.135698
XBP1 X-box binding protein 1 0.134874
TACR1 tachykinin receptor 1 0.134321