bilirubin metabolic disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An inherited metabolic disorder that involves elevated levels of bilirubin resulting from disruption of bilirubin metabolism. (Human Disease Ontology, DOID_2741)
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Genes

201 genes co-occuring with the disease bilirubin metabolic disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 3.16776
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 2.9268
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5 2.28212
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 2.25848
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 2.25001
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 2.2463
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.23726
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 2.22713
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 2.22286
G6PD glucose-6-phosphate dehydrogenase 2.16602
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 2.14073
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.0545
PKM pyruvate kinase, muscle 1.85
SLCO1B1 solute carrier organic anion transporter family, member 1B1 1.79255
ALB albumin 1.77135
NT5C1A 5'-nucleotidase, cytosolic IA 1.63232
B3GAT2 beta-1,3-glucuronyltransferase 2 1.58894
ALPPL2 alkaline phosphatase, placental-like 2 1.57467
ALPP alkaline phosphatase, placental 1.57423
ALPL alkaline phosphatase, liver/bone/kidney 1.57378
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.5538
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.39302
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.38559
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.36684
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 1.34592
SLCO1B3 solute carrier organic anion transporter family, member 1B3 1.30663
F2 coagulation factor II (thrombin) 1.27432
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.19921
GGT1 gamma-glutamyltransferase 1 1.19316
NT5C2 5'-nucleotidase, cytosolic II 1.15538
UGP2 UDP-glucose pyrophosphorylase 2 1.06732
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 1.03577
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.03493
UGT3A2 UDP glycosyltransferase 3 family, polypeptide A2 0.966663
GLS2 glutaminase 2 (liver, mitochondrial) 0.950769
GUSB glucuronidase, beta 0.944521
GGT2 gamma-glutamyltransferase 2 0.935385
HMOX1 heme oxygenase 1 0.927932
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 0.904032
PKLR pyruvate kinase, liver and RBC 0.900746
RHD Rh blood group, D antigen 0.897051
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 0.879424
UGT3A1 UDP glycosyltransferase 3 family, polypeptide A1 0.879014
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.876557
RHCE Rh blood group, CcEe antigens 0.868777
HP haptoglobin 0.865502
HPR haptoglobin-related protein 0.858952
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 0.857724
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11 0.831918
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 0.826999
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 0.815104
ATP11C ATPase, class VI, type 11C 0.81059
MRPS7 mitochondrial ribosomal protein S7 0.806488
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 0.786803
SHB Src homology 2 domain containing adaptor protein B 0.76921
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 0.763086
F3 coagulation factor III (thromboplastin, tissue factor) 0.72612
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.723694
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.711183
CD33 CD33 molecule 0.689893
INS insulin 0.671925
CRP C-reactive protein, pentraxin-related 0.660404
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.639463
PPP1R17 protein phosphatase 1, regulatory subunit 17 0.622183
AFP alpha-fetoprotein 0.617094
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 0.614356
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 0.60108
CD4 CD4 molecule 0.596012
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 0.592506
SLCO1A2 solute carrier organic anion transporter family, member 1A2 0.588222
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 0.559062
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 0.550134
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.548195
TAAR8 trace amine associated receptor 8 0.529994
SRY sex determining region Y 0.527676
UROS uroporphyrinogen III synthase 0.509192
TECR trans-2,3-enoyl-CoA reductase 0.50459
IL2 interleukin 2 0.498085
CDAN1 codanin 1 0.493885
VPS33B vacuolar protein sorting 33 homolog B (yeast) 0.492359
RBM25 RNA binding motif protein 25 0.465794
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 0.460883
PEX14 peroxisomal biogenesis factor 14 0.455601
SORD sorbitol dehydrogenase 0.450324
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 0.445052
FTH1 ferritin, heavy polypeptide 1 0.443171
FTL ferritin, light polypeptide 0.443171
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.440538
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 0.438282
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.428891
PLEKHN1 pleckstrin homology domain containing, family N member 1 0.427015
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.422515
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.42139
ALAS1 5'-aminolevulinate synthase 1 0.413527
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 0.412779
GSTA2 glutathione S-transferase alpha 2 0.397471
NUP153 nucleoporin 153kDa 0.394863
HPX hemopexin 0.393374
GPX5 glutathione peroxidase 5 0.392629
GSTA1 glutathione S-transferase alpha 1 0.390397
GPX4 glutathione peroxidase 4 0.389653
CP ceruloplasmin (ferroxidase) 0.385565
NT5E 5'-nucleotidase, ecto (CD73) 0.374809
GPX1 glutathione peroxidase 1 0.374438
BLVRA biliverdin reductase A 0.372958
GSTA3 glutathione S-transferase alpha 3 0.351187
TMBIM4 transmembrane BAX inhibitor motif containing 4 0.350452
GSTA4 glutathione S-transferase alpha 4 0.348614
NBAS neuroblastoma amplified sequence 0.346777
HMOX2 heme oxygenase 2 0.33651
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.335412
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 0.332121
LHFPL5 lipoma HMGIC fusion partner-like 5 0.330295
EPB42 erythrocyte membrane protein band 4.2 0.32774
GPI glucose-6-phosphate isomerase 0.326281
POR P450 (cytochrome) oxidoreductase 0.309204
BAAT bile acid CoA:amino acid N-acyltransferase 0.298731
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 0.292975
RDX radixin 0.292975
HBA2 hemoglobin, alpha 2 0.283297
TOP1 topoisomerase (DNA) I 0.278297
HBE1 hemoglobin, epsilon 1 0.269753
TDO2 tryptophan 2,3-dioxygenase 0.26514
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.252422
CPOX coproporphyrinogen oxidase 0.250311
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 0.247852
GALT galactose-1-phosphate uridylyltransferase 0.246799
TRIM37 tripartite motif containing 37 0.246799
OR5K1 olfactory receptor, family 5, subfamily K, member 1 0.245046
TPX2 TPX2, microtubule-associated 0.241546
GRHL1 grainyhead-like 1 (Drosophila) 0.240497
SEC23B Sec23 homolog B (S. cerevisiae) 0.237357
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.237009
PRAMEF10 PRAME family member 10 0.234573
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.22937
TNF tumor necrosis factor 0.222136
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.222136
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.214636
MSN moesin 0.210925
MGAM maltase-glucoamylase 0.208245
HBA1 hemoglobin, alpha 1 0.207912
RER1 retention in endoplasmic reticulum sorting receptor 1 0.20229
HFE hemochromatosis 0.201308
FECH ferrochelatase 0.200982
PMF1 polyamine-modulated factor 1 0.19742
HMBS hydroxymethylbilane synthase 0.194232
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.192344
SLC26A3 solute carrier family 26 (anion exchanger), member 3 0.192031
RELT RELT tumor necrosis factor receptor 0.191408
OPLAH 5-oxoprolinase (ATP-hydrolysing) 0.191097
DPYD dihydropyrimidine dehydrogenase 0.190786
CAT catalase 0.187415
WRB tryptophan rich basic protein 0.18472
BORA bora, aurora kinase A activator 0.183248
NOVA2 neuro-oncological ventral antigen 2 0.183248
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.180367
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.17952
BRD7 bromodomain containing 7 0.175146
GSR glutathione reductase 0.174354
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.173057
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 0.172038
IL6 interleukin 6 0.169571
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 0.166544
MVP major vault protein 0.165874
TYMP thymidine phosphorylase 0.162908
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 0.161331
UGDH UDP-glucose 6-dehydrogenase 0.160948
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.160574
VWF von Willebrand factor 0.158097
IL1B interleukin 1, beta 0.157929
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.143544
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.143433
SLCO1C1 solute carrier organic anion transporter family, member 1C1 0.14337
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.143191
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 0.142584
EZR ezrin 0.141734
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.141709
FBLIM1 filamin binding LIM protein 1 0.141628
AGXT alanine-glyoxylate aminotransferase 0.140893
CNR2 cannabinoid receptor 2 (macrophage) 0.138994
HFE2 hemochromatosis type 2 (juvenile) 0.138633
SPA17 sperm autoantigenic protein 17 0.13819
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.13812
TFR2 transferrin receptor 2 0.137926
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 0.137747
TPMT thiopurine S-methyltransferase 0.136643
ASGR2 asialoglycoprotein receptor 2 0.136493
AICDA activation-induced cytidine deaminase 0.136077
ASGR1 asialoglycoprotein receptor 1 0.135929
DPP4 dipeptidyl-peptidase 4 0.134838
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 0.133516
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 0.132078
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.131541
GSTP1 glutathione S-transferase pi 1 0.131091
NR1H4 nuclear receptor subfamily 1, group H, member 4 0.130811
ALPI alkaline phosphatase, intestinal 0.130378
ATP7B ATPase, Cu++ transporting, beta polypeptide 0.12943
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.128342
OTC ornithine carbamoyltransferase 0.128166
DLL1 delta-like 1 (Drosophila) 0.127623
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.126497