bicuculline-2139 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the bicuculline-2139 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
AAMDC adipogenesis associated, Mth938 domain containing
AFF3 AF4/FMR2 family, member 3
AGTPBP1 ATP/GTP binding protein 1
ARMC4 armadillo repeat containing 4
ARR3 arrestin 3, retinal (X-arrestin)
ASMT acetylserotonin O-methyltransferase
ATP13A2 ATPase type 13A2
B9D2 B9 protein domain 2
BIN1 bridging integrator 1
BMP7 bone morphogenetic protein 7
BTN3A1 butyrophilin, subfamily 3, member A1
C11ORF16 chromosome 11 open reading frame 16
C1ORF95 chromosome 1 open reading frame 95
CADM3 cell adhesion molecule 3
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CDK19 cyclin-dependent kinase 19
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLMN calmin (calponin-like, transmembrane)
CNTNAP2 contactin associated protein-like 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
COPE coatomer protein complex, subunit epsilon
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CREM cAMP responsive element modulator
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CSNK1E casein kinase 1, epsilon
CTNS cystinosin, lysosomal cystine transporter
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DLG3 discs, large homolog 3 (Drosophila)
DPEP2 dipeptidase 2
DUS2 dihydrouridine synthase 2
EGOT eosinophil granule ontogeny transcript (non-protein coding)
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EXTL3 exostosin-like glycosyltransferase 3
FAM65A family with sequence similarity 65, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FRMPD1 FERM and PDZ domain containing 1
FYB FYN binding protein
GALC galactosylceramidase
GJA4 gap junction protein, alpha 4, 37kDa
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GP6 glycoprotein VI (platelet)
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR137 G protein-coupled receptor 137
HIF3A hypoxia inducible factor 3, alpha subunit
HOXA3 homeobox A3
HSPG2 heparan sulfate proteoglycan 2
IFI6 interferon, alpha-inducible protein 6
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LAMP1 lysosomal-associated membrane protein 1
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LMAN1 lectin, mannose-binding, 1
LRRC6 leucine rich repeat containing 6
MED25 mediator complex subunit 25
MORN1 MORN repeat containing 1
MRPS12 mitochondrial ribosomal protein S12
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYO1B myosin IB
NARFL nuclear prelamin A recognition factor-like
NOV nephroblastoma overexpressed
NPEPL1 aminopeptidase-like 1
ORAI2 ORAI calcium release-activated calcium modulator 2
PADI4 peptidyl arginine deiminase, type IV
PCDH9 protocadherin 9
PDLIM5 PDZ and LIM domain 5
PEX16 peroxisomal biogenesis factor 16
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PID1 phosphotyrosine interaction domain containing 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPARD peroxisome proliferator-activated receptor delta
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PTAFR platelet-activating factor receptor
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAB3A RAB3A, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RPH3AL rabphilin 3A-like (without C2 domains)
RPL10 ribosomal protein L10
RTEL1 regulator of telomere elongation helicase 1
RUSC2 RUN and SH3 domain containing 2
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC35G2 solute carrier family 35, member G2
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SOX10 SRY (sex determining region Y)-box 10
SRPK2 SRSF protein kinase 2
STX2 syntaxin 2
TRDMT1 tRNA aspartic acid methyltransferase 1
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
TUBA4B tubulin, alpha 4b
VCPKMT valosin containing protein lysine (K) methyltransferase
ZMAT5 zinc finger, matrin-type 5
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF234 zinc finger protein 234
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ALPK1 alpha-kinase 1
ALS2CL ALS2 C-terminal like
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATAT1 alpha tubulin acetyltransferase 1
BBC3 BCL2 binding component 3
BNC2 basonuclin 2
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C12ORF43 chromosome 12 open reading frame 43
C22ORF46 chromosome 22 open reading frame 46
C7ORF43 chromosome 7 open reading frame 43
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNR2 cannabinoid receptor 2 (macrophage)
CNTN1 contactin 1
CORT cortistatin
CTSD cathepsin D
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DEPDC5 DEP domain containing 5
DHRS9 dehydrogenase/reductase (SDR family) member 9
DOLK dolichol kinase
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ELP6 elongator acetyltransferase complex subunit 6
ERCC4 excision repair cross-complementation group 4
FAM63A family with sequence similarity 63, member A
FBRS fibrosin
FMO4 flavin containing monooxygenase 4
FOXN2 forkhead box N2
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GIPC1 GIPC PDZ domain containing family, member 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GSTT1 glutathione S-transferase theta 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H2AM histone cluster 1, H2am
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL11RA interleukin 11 receptor, alpha
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INO80D INO80 complex subunit D
IPO8 importin 8
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KDM5C lysine (K)-specific demethylase 5C
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0753 KIAA0753
KLHL26 kelch-like family member 26
KRT8P12 keratin 8 pseudogene 12
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYPLA2P1 lysophospholipase II pseudogene 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGEH1 melanoma antigen family H1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MBIP MAP3K12 binding inhibitory protein 1
MOCS3 molybdenum cofactor synthesis 3
NABP1 nucleic acid binding protein 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NLK nemo-like kinase
PARG poly (ADP-ribose) glycohydrolase
PEX26 peroxisomal biogenesis factor 26
PMFBP1 polyamine modulated factor 1 binding protein 1
PRAF2 PRA1 domain family, member 2
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAP1GAP2 RAP1 GTPase activating protein 2
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RNF122 ring finger protein 122
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF2 ring finger protein 2
RRAS related RAS viral (r-ras) oncogene homolog
SCGB2A2 secretoglobin, family 2A, member 2
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SERGEF secretion regulating guanine nucleotide exchange factor
SERTAD3 SERTA domain containing 3
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SOX12 SRY (sex determining region Y)-box 12
SP140L SP140 nuclear body protein-like
SPAG4 sperm associated antigen 4
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STX1A syntaxin 1A (brain)
SV2A synaptic vesicle glycoprotein 2A
SYCP2 synaptonemal complex protein 2
TBC1D17 TBC1 domain family, member 17
TCTN2 tectonic family member 2
TICAM1 toll-like receptor adaptor molecule 1
TLN1 talin 1
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TTC23 tetratricopeptide repeat domain 23
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
USB1 U6 snRNA biogenesis 1
VEGFB vascular endothelial growth factor B
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H3 zinc finger CCCH-type containing 3
ZNF34 zinc finger protein 34