betulinic acid Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium claviflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties. (Chemical Entities of Biological Interest Ontology, CHEBI_3087)
External Link http://ctdbase.org/detail.go?type=chem&acc=C002070
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Genes

22 genes/proteins interacting with the chemical betulinic acid from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AKT1 v-akt murine thymoma viral oncogene homolog 1
BAX BCL2-associated X protein
BIRC5 baculoviral IAP repeat containing 5
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CTSK cathepsin K
EGFR epidermal growth factor receptor
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PTHLH parathyroid hormone-like hormone
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SMAD3 SMAD family member 3
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
Funding