betulinic acid-4101 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the betulinic acid-4101 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ADAP1 ArfGAP with dual PH domains 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIF1 allograft inflammatory factor 1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
APOC1 apolipoprotein C-I
APP amyloid beta (A4) precursor protein
ARHGAP26 Rho GTPase activating protein 26
ARSD arylsulfatase D
ATP10A ATPase, class V, type 10A
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C7ORF26 chromosome 7 open reading frame 26
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CCK cholecystokinin
CCL22 chemokine (C-C motif) ligand 22
CCR7 chemokine (C-C motif) receptor 7
CD52 CD52 molecule
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CEMP1 cementum protein 1
CLCN4 chloride channel, voltage-sensitive 4
CLEC10A C-type lectin domain family 10, member A
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CSF1 colony stimulating factor 1 (macrophage)
CYTH3 cytohesin 3
DRP2 dystrophin related protein 2
DSCAM Down syndrome cell adhesion molecule
DUX4L8 double homeobox 4 like 8
EGFL7 EGF-like-domain, multiple 7
EMX1 empty spiracles homeobox 1
EYA2 EYA transcriptional coactivator and phosphatase 2
FABP1 fatty acid binding protein 1, liver
FAM65B family with sequence similarity 65, member B
FLT4 fms-related tyrosine kinase 4
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GFER growth factor, augmenter of liver regeneration
GHRH growth hormone releasing hormone
GJA8 gap junction protein, alpha 8, 50kDa
GJB3 gap junction protein, beta 3, 31kDa
GPR75 G protein-coupled receptor 75
HGD homogentisate 1,2-dioxygenase
HOXD13 homeobox D13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IAPP islet amyloid polypeptide
INS insulin
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
JAG1 jagged 1
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KIAA0125 KIAA0125
KRT37 keratin 37, type I
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MEF2D myocyte enhancer factor 2D
MGAM maltase-glucoamylase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
ODAM odontogenic, ameloblast asssociated
PAOX polyamine oxidase (exo-N4-amino)
PBRM1 polybromo 1
PCDHB17P protocadherin beta 17 pseudogene
PDE11A phosphodiesterase 11A
PIP prolactin-induced protein
POLL polymerase (DNA directed), lambda
POM121L2 POM121 transmembrane nucleoporin-like 2
POU3F2 POU class 3 homeobox 2
POU6F2 POU class 6 homeobox 2
PRDM2 PR domain containing 2, with ZNF domain
PTH1R parathyroid hormone 1 receptor
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RARA retinoic acid receptor, alpha
RARB retinoic acid receptor, beta
REG1A regenerating islet-derived 1 alpha
RGR retinal G protein coupled receptor
RPS6 ribosomal protein S6
RS1 retinoschisin 1
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SOX2 SRY (sex determining region Y)-box 2
SPRR2B small proline-rich protein 2B
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
SUSD5 sushi domain containing 5
SYNPO2L synaptopodin 2-like
TBC1D2 TBC1 domain family, member 2
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TDRD12 tudor domain containing 12
TESPA1 thymocyte expressed, positive selection associated 1
TMEM206 transmembrane protein 206
TRGV5 T cell receptor gamma variable 5
TSPY1 testis specific protein, Y-linked 1
USH2A Usher syndrome 2A (autosomal recessive, mild)
WNT8B wingless-type MMTV integration site family, member 8B
ZNF814 zinc finger protein 814

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGAP10 Rho GTPase activating protein 10
ARR3 arrestin 3, retinal (X-arrestin)
BAX BCL2-associated X protein
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C1ORF105 chromosome 1 open reading frame 105
CHM choroideremia (Rab escort protein 1)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLDN11 claudin 11
CLIC3 chloride intracellular channel 3
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNN1 calponin 1, basic, smooth muscle
CUZD1 CUB and zona pellucida-like domains 1
DCAF13 DDB1 and CUL4 associated factor 13
DMBT1 deleted in malignant brain tumors 1
ERAP2 endoplasmic reticulum aminopeptidase 2
ERF Ets2 repressor factor
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1LB ERO1-like beta (S. cerevisiae)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FBRS fibrosin
FBXO22 F-box protein 22
FBXO31 F-box protein 31
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FKBP5 FK506 binding protein 5
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H4E histone cluster 1, H4e
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSF2BP heat shock transcription factor 2 binding protein
IFI6 interferon, alpha-inducible protein 6
IFT140 intraflagellar transport 140
IL17RB interleukin 17 receptor B
INO80D INO80 complex subunit D
ISYNA1 inositol-3-phosphate synthase 1
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIAA1107 KIAA1107
LIG4 ligase IV, DNA, ATP-dependent
LMNB1 lamin B1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MBTD1 mbt domain containing 1
MCC mutated in colorectal cancers
MCTP2 multiple C2 domains, transmembrane 2
MED31 mediator complex subunit 31
MMP9 matrix metallopeptidase 9
MYO1E myosin IE
NOD1 nucleotide-binding oligomerization domain containing 1
NOL10 nucleolar protein 10
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAX9 paired box 9
PEX26 peroxisomal biogenesis factor 26
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCD1 phospholipase C, delta 1
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRSS22 protease, serine, 22
PWAR5 Prader Willi/Angelman region RNA 5
PXMP4 peroxisomal membrane protein 4, 24kDa
RAB3A RAB3A, member RAS oncogene family
RPH3AL rabphilin 3A-like (without C2 domains)
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAGB Ras-related GTP binding B
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SCYL2 SCY1-like 2 (S. cerevisiae)
SELL selectin L
SLC12A9 solute carrier family 12, member 9
SLN sarcolipin
SPRYD7 SPRY domain containing 7
SSTR4 somatostatin receptor 4
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TEX40 testis expressed 40
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TUBA3C tubulin, alpha 3c
WDR25 WD repeat domain 25
WDR76 WD repeat domain 76
YY2 YY2 transcription factor
ZBTB22 zinc finger and BTB domain containing 22
ZBTB6 zinc finger and BTB domain containing 6
ZNF227 zinc finger protein 227
ZNF358 zinc finger protein 358
ZNF446 zinc finger protein 446
ZNF549 zinc finger protein 549
ZNF749 zinc finger protein 749
ZNF76 zinc finger protein 76