betulin-7454 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the betulin-7454 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACRV1 acrosomal vesicle protein 1
AKR1C1 aldo-keto reductase family 1, member C1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
APOC1 apolipoprotein C-I
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
BCL2 B-cell CLL/lymphoma 2
BMP5 bone morphogenetic protein 5
C1QL1 complement component 1, q subcomponent-like 1
C5ORF45 chromosome 5 open reading frame 45
CAPG capping protein (actin filament), gelsolin-like
CDC14A cell division cycle 14A
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
DLG5 discs, large homolog 5 (Drosophila)
DST dystonin
DUSP13 dual specificity phosphatase 13
EPB41L5 erythrocyte membrane protein band 4.1 like 5
FLJ42627 uncharacterized LOC645644
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GJB3 gap junction protein, beta 3, 31kDa
GLB1L galactosidase, beta 1-like
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
HFE hemochromatosis
HLA-C major histocompatibility complex, class I, C
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSF1 heat shock transcription factor 1
HSPG2 heparan sulfate proteoglycan 2
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IQCK IQ motif containing K
KDM8 lysine (K)-specific demethylase 8
KLHL22 kelch-like family member 22
KLHL25 kelch-like family member 25
LENEP lens epithelial protein
LINC01587 long intergenic non-protein coding RNA 1587
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MASP2 mannan-binding lectin serine peptidase 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MID1 midline 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
NF1 neurofibromin 1
NPFFR1 neuropeptide FF receptor 1
NUP62CL nucleoporin 62kDa C-terminal like
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PCNX pecanex homolog (Drosophila)
PDLIM5 PDZ and LIM domain 5
PHC3 polyhomeotic homolog 3 (Drosophila)
PHKA2 phosphorylase kinase, alpha 2 (liver)
PML promyelocytic leukemia
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKCE protein kinase C, epsilon
PTPRS protein tyrosine phosphatase, receptor type, S
RABGAP1 RAB GTPase activating protein 1
RANBP3 RAN binding protein 3
RARA retinoic acid receptor, alpha
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIN3 Ras and Rab interactor 3
RNFT2 ring finger protein, transmembrane 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RTEL1 regulator of telomere elongation helicase 1
S100A8 S100 calcium binding protein A8
SCUBE3 signal peptide, CUB domain, EGF-like 3
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SH3GL3 SH3-domain GRB2-like 3
SIK3 SIK family kinase 3
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SNCG synuclein, gamma (breast cancer-specific protein 1)
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STAT5B signal transducer and activator of transcription 5B
STX7 syntaxin 7
SUGP1 SURP and G patch domain containing 1
TAZ tafazzin
TEX40 testis expressed 40
TLE4 transducin-like enhancer of split 4
TMC7 transmembrane channel-like 7
TMEM57 transmembrane protein 57
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRIM2 tripartite motif containing 2
TRIM68 tripartite motif containing 68
TTC9 tetratricopeptide repeat domain 9
TTLL5 tubulin tyrosine ligase-like family member 5
USP2 ubiquitin specific peptidase 2
USP34 ubiquitin specific peptidase 34
VAMP5 vesicle-associated membrane protein 5
ZNF211 zinc finger protein 211

decreased expression

Symbol Name
AGBL5 ATP/GTP binding protein-like 5
ATAD3A ATPase family, AAA domain containing 3A
ATP11B ATPase, class VI, type 11B
C11ORF95 chromosome 11 open reading frame 95
C7ORF43 chromosome 7 open reading frame 43
CD320 CD320 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CIC capicua transcriptional repressor
CISH cytokine inducible SH2-containing protein
DDIT3 DNA-damage-inducible transcript 3
DEAF1 DEAF1 transcription factor
DIXDC1 DIX domain containing 1
DNAL4 dynein, axonemal, light chain 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSCAM Down syndrome cell adhesion molecule
DUSP8 dual specificity phosphatase 8
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EFNA3 ephrin-A3
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ERO1L ERO1-like (S. cerevisiae)
FAM118A family with sequence similarity 118, member A
FAM192A family with sequence similarity 192, member A
FBXO46 F-box protein 46
FEM1C fem-1 homolog c (C. elegans)
FRS2 fibroblast growth factor receptor substrate 2
GAB2 GRB2-associated binding protein 2
GCHFR GTP cyclohydrolase I feedback regulator
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GRAMD3 GRAM domain containing 3
GRAMD4 GRAM domain containing 4
HDAC11 histone deacetylase 11
HIST2H2AA3 histone cluster 2, H2aa3
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KIZ kizuna centrosomal protein
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LHX1 LIM homeobox 1
LNPEP leucyl/cystinyl aminopeptidase
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC61 leucine rich repeat containing 61
LZTFL1 leucine zipper transcription factor-like 1
MAMLD1 mastermind-like domain containing 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPKBP1 mitogen-activated protein kinase binding protein 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCMBP minichromosome maintenance complex binding protein
MED15 mediator complex subunit 15
METTL16 methyltransferase like 16
MFSD11 major facilitator superfamily domain containing 11
MRPL44 mitochondrial ribosomal protein L44
MSX1 msh homeobox 1
MXD3 MAX dimerization protein 3
NACA2 nascent polypeptide-associated complex alpha subunit 2
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G15 phospholipase A2, group XV
PQLC1 PQ loop repeat containing 1
PRODH proline dehydrogenase (oxidase) 1
PTPRE protein tyrosine phosphatase, receptor type, E
RABL3 RAB, member of RAS oncogene family-like 3
RARS arginyl-tRNA synthetase
RNF121 ring finger protein 121
RNF219 ring finger protein 219
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SAV1 salvador family WW domain containing protein 1
SCAMP5 secretory carrier membrane protein 5
SCHIP1 schwannomin interacting protein 1
SERTAD3 SERTA domain containing 3
SFT2D2 SFT2 domain containing 2
SIK1 salt-inducible kinase 1
SLC12A9 solute carrier family 12, member 9
SLC35F5 solute carrier family 35, member F5
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SMA4 glucuronidase, beta pseudogene
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SP1 Sp1 transcription factor
SREK1IP1 SREK1-interacting protein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAG3 stromal antigen 3
STK16 serine/threonine kinase 16
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TMPRSS4 transmembrane protease, serine 4
TMSB15A thymosin beta 15a
UBIAD1 UbiA prenyltransferase domain containing 1
UFSP2 UFM1-specific peptidase 2
USB1 U6 snRNA biogenesis 1
USP18 ubiquitin specific peptidase 18
VAV1 vav 1 guanine nucleotide exchange factor
VGF VGF nerve growth factor inducible
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
YIPF1 Yip1 domain family, member 1
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF219 zinc finger protein 219
ZNF324 zinc finger protein 324