betonicine-4767 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the betonicine-4767 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
AATK apoptosis-associated tyrosine kinase
ALOXE3 arachidonate lipoxygenase 3
ANTXR1 anthrax toxin receptor 1
AP3B2 adaptor-related protein complex 3, beta 2 subunit
ASIC1 acid sensing (proton gated) ion channel 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BST2 bone marrow stromal cell antigen 2
CAMK1D calcium/calmodulin-dependent protein kinase ID
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD22 CD22 molecule
CDK18 cyclin-dependent kinase 18
CDK19 cyclin-dependent kinase 19
CHL1 cell adhesion molecule L1-like
CLCNKB chloride channel, voltage-sensitive Kb
COL1A1 collagen, type I, alpha 1
CPA4 carboxypeptidase A4
CPN2 carboxypeptidase N, polypeptide 2
CPNE7 copine VII
CYB5R2 cytochrome b5 reductase 2
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCX doublecortin
DHRS12 dehydrogenase/reductase (SDR family) member 12
DTX2 deltex 2, E3 ubiquitin ligase
EFR3B EFR3 homolog B (S. cerevisiae)
FBXO2 F-box protein 2
FCMR Fc fragment of IgM receptor
FRMD1 FERM domain containing 1
FUT2 fucosyltransferase 2 (secretor status included)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GIPR gastric inhibitory polypeptide receptor
GK2 glycerol kinase 2
GPR3 G protein-coupled receptor 3
GREB1L growth regulation by estrogen in breast cancer-like
GRPR gastrin-releasing peptide receptor
HAPLN1 hyaluronan and proteoglycan link protein 1
HFE hemochromatosis
HLA-DOA major histocompatibility complex, class II, DO alpha
HMGN5 high mobility group nucleosome binding domain 5
HPX hemopexin
HYAL3 hyaluronoglucosaminidase 3
ICA1 islet cell autoantigen 1, 69kDa
ICOS inducible T-cell co-stimulator
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGHMBP2 immunoglobulin mu binding protein 2
IL11 interleukin 11
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA8 integrin, alpha 8
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF25-AS1 KIF25 antisense RNA 1
KLF12 Kruppel-like factor 12
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMB4 laminin, beta 4
LOX lysyl oxidase
MAN1A2 mannosidase, alpha, class 1A, member 2
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NTF3 neurotrophin 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCDH12 protocadherin 12
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM4 PDZ and LIM domain 4
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHF3 PHD finger protein 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCD1 phospholipase C, delta 1
PLLP plasmolipin
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PTRF polymerase I and transcript release factor
RAP1GAP RAP1 GTPase activating protein
RASAL2 RAS protein activator like 2
RBM48 RNA binding motif protein 48
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIN3 Ras and Rab interactor 3
RNF126P1 ring finger protein 126 pseudogene 1
RPL10L ribosomal protein L10-like
RPS3A ribosomal protein S3A
SENP7 SUMO1/sentrin specific peptidase 7
SFRP4 secreted frizzled-related protein 4
SH3GL3 SH3-domain GRB2-like 3
SIT1 signaling threshold regulating transmembrane adaptor 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SULT4A1 sulfotransferase family 4A, member 1
TCEAL2 transcription elongation factor A (SII)-like 2
TESC tescalcin
TMEM45A transmembrane protein 45A
TNS1 tensin 1
TP63 tumor protein p63
TSC22D4 TSC22 domain family, member 4
TSPAN9 tetraspanin 9
UBA6 ubiquitin-like modifier activating enzyme 6
ZEB1 zinc finger E-box binding homeobox 1
ZFYVE9 zinc finger, FYVE domain containing 9

decreased expression

Symbol Name
ACTL8 actin-like 8
ACYP2 acylphosphatase 2, muscle type
ADAP2 ArfGAP with dual PH domains 2
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ASAP1-IT1 ASAP1 intronic transcript 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
AUTS2 autism susceptibility candidate 2
C11ORF30 chromosome 11 open reading frame 30
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAPG capping protein (actin filament), gelsolin-like
CCDC85C coiled-coil domain containing 85C
CD82 CD82 molecule
CD8A CD8a molecule
CHRM3 cholinergic receptor, muscarinic 3
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLEC7A C-type lectin domain family 7, member A
CSF1R colony stimulating factor 1 receptor
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DENND4A DENN/MADD domain containing 4A
DNM3 dynamin 3
DUSP2 dual specificity phosphatase 2
DYM dymeclin
EPHX2 epoxide hydrolase 2, cytoplasmic
FADS2 fatty acid desaturase 2
FAM120C family with sequence similarity 120C
FAM198B family with sequence similarity 198, member B
FFAR2 free fatty acid receptor 2
FMOD fibromodulin
GLRA1 glycine receptor, alpha 1
GMPR guanosine monophosphate reductase
GPR19 G protein-coupled receptor 19
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HAMP hepcidin antimicrobial peptide
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H4E histone cluster 1, H4e
HIST1H4F histone cluster 1, H4f
HMOX1 heme oxygenase 1
HOXC8 homeobox C8
HYI hydroxypyruvate isomerase (putative)
IL22 interleukin 22
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KDM7A lysine (K)-specific demethylase 7A
LINC00597 long intergenic non-protein coding RNA 597
MDM4 MDM4, p53 regulator
METTL16 methyltransferase like 16
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MMRN2 multimerin 2
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPS18C mitochondrial ribosomal protein S18C
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NKX3-2 NK3 homeobox 2
NNAT neuronatin
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPTX1 neuronal pentraxin I
OSMR oncostatin M receptor
PARPBP PARP1 binding protein
PCDHB13 protocadherin beta 13
PER3 period circadian clock 3
PGR progesterone receptor
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLA2G15 phospholipase A2, group XV
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLXNA3 plexin A3
PNRC1 proline-rich nuclear receptor coactivator 1
PODXL2 podocalyxin-like 2
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
RAI2 retinoic acid induced 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RFTN1 raftlin, lipid raft linker 1
RHOBTB2 Rho-related BTB domain containing 2
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
S100A2 S100 calcium binding protein A2
SAYSD1 SAYSVFN motif domain containing 1
SEC14L2 SEC14-like 2 (S. cerevisiae)
SERGEF secretion regulating guanine nucleotide exchange factor
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SMYD5 SMYD family member 5
SSBP3 single stranded DNA binding protein 3
STIM1 stromal interaction molecule 1
STX1A syntaxin 1A (brain)
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAOK1 TAO kinase 1
TFF2 trefoil factor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMC5 transmembrane channel-like 5
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRIM36 tripartite motif containing 36
TUBA3C tubulin, alpha 3c
ZFHX4 zinc finger homeobox 4
ZNF253 zinc finger protein 253
ZNF552 zinc finger protein 552
ZNF573 zinc finger protein 573