betonicine-3745 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the betonicine-3745 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
AAGAB alpha- and gamma-adaptin binding protein
ADRA1D adrenoceptor alpha 1D
ARC activity-regulated cytoskeleton-associated protein
ARTN artemin
ATG10 autophagy related 10
BBC3 BCL2 binding component 3
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD177 CD177 molecule
CDRT1 CMT1A duplicated region transcript 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLCN4 chloride channel, voltage-sensitive 4
CLEC2B C-type lectin domain family 2, member B
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A6 collagen, type IV, alpha 6
COL8A1 collagen, type VIII, alpha 1
CRHR2 corticotropin releasing hormone receptor 2
CTSZ cathepsin Z
CYBA cytochrome b-245, alpha polypeptide
DESI2 desumoylating isopeptidase 2
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DIO2 deiodinase, iodothyronine, type II
DKFZP434C153 DKFZP434C153 protein
DMP1 dentin matrix acidic phosphoprotein 1
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DPYSL4 dihydropyrimidinase-like 4
DSCAM Down syndrome cell adhesion molecule
DUSP2 dual specificity phosphatase 2
EDN1 endothelin 1
EDRF1 erythroid differentiation regulatory factor 1
EGR1 early growth response 1
F2RL3 coagulation factor II (thrombin) receptor-like 3
FGF22 fibroblast growth factor 22
FLRT2 fibronectin leucine rich transmembrane protein 2
FLT4 fms-related tyrosine kinase 4
FRMD4A FERM domain containing 4A
FRS3 fibroblast growth factor receptor substrate 3
GAP43 growth associated protein 43
GFER growth factor, augmenter of liver regeneration
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GRK5 G protein-coupled receptor kinase 5
HABP4 hyaluronan binding protein 4
HSF1 heat shock transcription factor 1
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IGLJ3 immunoglobulin lambda joining 3
IL36G interleukin 36, gamma
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
LOC100294391 uncharacterized LOC100294391
LY9 lymphocyte antigen 9
MEF2D myocyte enhancer factor 2D
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MYL10 myosin, light chain 10, regulatory
NCOR2 nuclear receptor corepressor 2
NCR2 natural cytotoxicity triggering receptor 2
NIPAL2 NIPA-like domain containing 2
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
ONECUT2 one cut homeobox 2
PARP11 poly (ADP-ribose) polymerase family, member 11
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PHF20 PHD finger protein 20
PIGR polymeric immunoglobulin receptor
PLEKHS1 pleckstrin homology domain containing, family S member 1
PLK3 polo-like kinase 3
PQLC2 PQ loop repeat containing 2
PRB1 proline-rich protein BstNI subfamily 1
PRM1 protamine 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PVR poliovirus receptor
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RGS4 regulator of G-protein signaling 4
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RPL10 ribosomal protein L10
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SFRP1 secreted frizzled-related protein 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
STAB2 stabilin 2
SULT4A1 sulfotransferase family 4A, member 1
TBX1 T-box 1
TBX6 T-box 6
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TFCP2L1 transcription factor CP2-like 1
TLK1 tousled-like kinase 1
TMEM259 transmembrane protein 259
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TP53I11 tumor protein p53 inducible protein 11
TSC22D2 TSC22 domain family, member 2
TSPAN32 tetraspanin 32
UBE2B ubiquitin-conjugating enzyme E2B
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
XYLB xylulokinase homolog (H. influenzae)
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF140 zinc finger protein 140

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ARPIN actin-related protein 2/3 complex inhibitor
ARSB arylsulfatase B
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BIRC7 baculoviral IAP repeat containing 7
C1QTNF3 C1q and tumor necrosis factor related protein 3
C1R complement component 1, r subcomponent
C3 complement component 3
C5ORF45 chromosome 5 open reading frame 45
CAMK4 calcium/calmodulin-dependent protein kinase IV
CDH19 cadherin 19, type 2
CEP97 centrosomal protein 97kDa
CHRM3 cholinergic receptor, muscarinic 3
CLSTN3 calsyntenin 3
CNPY4 canopy FGF signaling regulator 4
COBL cordon-bleu WH2 repeat protein
CRY2 cryptochrome circadian clock 2
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DNM3 dynamin 3
DOK5 docking protein 5
DYM dymeclin
EFCAB2 EF-hand calcium binding domain 2
EGF epidermal growth factor
FAM120C family with sequence similarity 120C
FAM204A family with sequence similarity 204, member A
FAM63A family with sequence similarity 63, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GLB1L galactosidase, beta 1-like
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
HAO2 hydroxyacid oxidase 2 (long chain)
HIST1H1D histone cluster 1, H1d
HOXA4 homeobox A4
HOXA7 homeobox A7
HSF2BP heat shock transcription factor 2 binding protein
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IFI6 interferon, alpha-inducible protein 6
IFT22 intraflagellar transport 22
IL22 interleukin 22
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRT37 keratin 37, type I
KRT86 keratin 86, type II
LINC00341 long intergenic non-protein coding RNA 341
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAGEA3 melanoma antigen family A3
MCMBP minichromosome maintenance complex binding protein
MDM4 MDM4, p53 regulator
METTL16 methyltransferase like 16
MLYCD malonyl-CoA decarboxylase
MYOZ3 myozenin 3
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NPHP1 nephronophthisis 1 (juvenile)
NSUN6 NOP2/Sun domain family, member 6
PACS1 phosphofurin acidic cluster sorting protein 1
PCDHA9 protocadherin alpha 9
PGLYRP4 peptidoglycan recognition protein 4
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PRAMEF10 PRAME family member 10
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPRS protein tyrosine phosphatase, receptor type, S
RAB30 RAB30, member RAS oncogene family
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RGCC regulator of cell cycle
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF126P1 ring finger protein 126 pseudogene 1
RNF39 ring finger protein 39
RPL13P5 ribosomal protein L13 pseudogene 5
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
S1PR1 sphingosine-1-phosphate receptor 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCD5 stearoyl-CoA desaturase 5
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLITRK5 SLIT and NTRK-like family, member 5
SLMO1 slowmo homolog 1 (Drosophila)
SPANXC SPANX family, member C
SPEG SPEG complex locus
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYNGR3 synaptogyrin 3
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TIGD6 tigger transposable element derived 6
TIMP4 TIMP metallopeptidase inhibitor 4
TRABD TraB domain containing
UBOX5 U-box domain containing 5
UNC119 unc-119 homolog (C. elegans)
VGF VGF nerve growth factor inducible
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZFP30 ZFP30 zinc finger protein
ZNF442 zinc finger protein 442
ZNF516 zinc finger protein 516
ZNF573 zinc finger protein 573
ZNF749 zinc finger protein 749