betonicine-3642 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the betonicine-3642 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
AGO4 argonaute RISC catalytic component 4
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BIRC3 baculoviral IAP repeat containing 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C10ORF95 chromosome 10 open reading frame 95
C1ORF95 chromosome 1 open reading frame 95
C3ORF18 chromosome 3 open reading frame 18
CAPN10 calpain 10
CASP2 caspase 2, apoptosis-related cysteine peptidase
CEP41 centrosomal protein 41kDa
CLEC2D C-type lectin domain family 2, member D
COL7A1 collagen, type VII, alpha 1
CREBZF CREB/ATF bZIP transcription factor
CTIF CBP80/20-dependent translation initiation factor
CXORF21 chromosome X open reading frame 21
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DMRT1 doublesex and mab-3 related transcription factor 1
DSC3 desmocollin 3
EFNB1 ephrin-B1
EFNB3 ephrin-B3
EFR3B EFR3 homolog B (S. cerevisiae)
ELP6 elongator acetyltransferase complex subunit 6
EPOR erythropoietin receptor
FABP7 fatty acid binding protein 7, brain
FAM189A1 family with sequence similarity 189, member A1
FGF2 fibroblast growth factor 2 (basic)
FLOT1 flotillin 1
GK glycerol kinase
GPR137 G protein-coupled receptor 137
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HEMK1 HemK methyltransferase family member 1
HIST1H3I histone cluster 1, H3i
HRASLS2 HRAS-like suppressor 2
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
IGLJ3 immunoglobulin lambda joining 3
KLHL18 kelch-like family member 18
LEPR leptin receptor
LMTK2 lemur tyrosine kinase 2
LRRC6 leucine rich repeat containing 6
LTB4R leukotriene B4 receptor
LTC4S leukotriene C4 synthase
MARK4 MAP/microtubule affinity-regulating kinase 4
MBD2 methyl-CpG binding domain protein 2
MKL1 megakaryoblastic leukemia (translocation) 1
MOBP myelin-associated oligodendrocyte basic protein
MON2 MON2 homolog (S. cerevisiae)
MSI1 musashi RNA-binding protein 1
MTRF1L mitochondrial translational release factor 1-like
MYLK myosin light chain kinase
NDN necdin, melanoma antigen (MAGE) family member
NEUROD1 neuronal differentiation 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NLRP1 NLR family, pyrin domain containing 1
NUMA1 nuclear mitotic apparatus protein 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSBPL10 oxysterol binding protein-like 10
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH1 protocadherin 1
PDAP1 PDGFA associated protein 1
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PNMA3 paraneoplastic Ma antigen 3
PON3 paraoxonase 3
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRY PTPN13-like, Y-linked
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTH1R parathyroid hormone 1 receptor
PURA purine-rich element binding protein A
RHAG Rh-associated glycoprotein
RHOH ras homolog family member H
RPL35A ribosomal protein L35a
S100A8 S100 calcium binding protein A8
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SGK2 serum/glucocorticoid regulated kinase 2
SH3BP2 SH3-domain binding protein 2
SKIL SKI-like proto-oncogene
SLC17A4 solute carrier family 17, member 4
SRPK2 SRSF protein kinase 2
SRSF5 serine/arginine-rich splicing factor 5
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STAT5B signal transducer and activator of transcription 5B
STMN3 stathmin-like 3
TAS2R1 taste receptor, type 2, member 1
TEX15 testis expressed 15
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TPM2 tropomyosin 2 (beta)
TRA2A transformer 2 alpha homolog (Drosophila)
TSC2 tuberous sclerosis 2
TTC39A tetratricopeptide repeat domain 39A
TTLL1 tubulin tyrosine ligase-like family member 1
TTLL4 tubulin tyrosine ligase-like family member 4
UMPS uridine monophosphate synthetase
WDR33 WD repeat domain 33
WNT16 wingless-type MMTV integration site family, member 16
ZBTB44 zinc finger and BTB domain containing 44
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
ADTRP androgen-dependent TFPI-regulating protein
AHSP alpha hemoglobin stabilizing protein
AIRE autoimmune regulator
AMT aminomethyltransferase
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARC activity-regulated cytoskeleton-associated protein
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BATF basic leucine zipper transcription factor, ATF-like
BMP10 bone morphogenetic protein 10
BMP15 bone morphogenetic protein 15
BTF3P11 basic transcription factor 3 pseudogene 11
C11ORF80 chromosome 11 open reading frame 80
C17ORF53 chromosome 17 open reading frame 53
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C8ORF44 chromosome 8 open reading frame 44
CCNK cyclin K
CD3D CD3d molecule, delta (CD3-TCR complex)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD82 CD82 molecule
CD83 CD83 molecule
CEP112 centrosomal protein 112kDa
CFAP70 cilia and flagella associated protein 70
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLIP4 CAP-GLY domain containing linker protein family, member 4
CORT cortistatin
CPNE7 copine VII
CRIP1 cysteine-rich protein 1 (intestinal)
CST6 cystatin E/M
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DEPDC5 DEP domain containing 5
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK2 docking protein 2, 56kDa
DSPP dentin sialophosphoprotein
EFNA3 ephrin-A3
EMID1 EMI domain containing 1
ERN2 endoplasmic reticulum to nucleus signaling 2
F2RL2 coagulation factor II (thrombin) receptor-like 2
FBXL7 F-box and leucine-rich repeat protein 7
FGF13 fibroblast growth factor 13
FOXF2 forkhead box F2
GALR2 galanin receptor 2
GPNMB glycoprotein (transmembrane) nmb
HCAR3 hydroxycarboxylic acid receptor 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST2H2AA3 histone cluster 2, H2aa3
HOXC5 homeobox C5
IHH indian hedgehog
ITM2C integral membrane protein 2C
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRT9 keratin 9, type I
LEFTY1 left-right determination factor 1
LIME1 Lck interacting transmembrane adaptor 1
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAOB monoamine oxidase B
MMP13 matrix metallopeptidase 13
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MOB3B MOB kinase activator 3B
MX1 MX dynamin-like GTPase 1
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit
NKX2-8 NK2 homeobox 8
NPY4R neuropeptide Y receptor Y4
ONECUT2 one cut homeobox 2
PCBP3 poly(rC) binding protein 3
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGLYRP4 peptidoglycan recognition protein 4
PWAR5 Prader Willi/Angelman region RNA 5
RAB40C RAB40C, member RAS oncogene family
RAI2 retinoic acid induced 2
RCAN3 RCAN family member 3
RELN reelin
RFPL1S RFPL1 antisense RNA 1
RNF39 ring finger protein 39
SH3D21 SH3 domain containing 21
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC16A4 solute carrier family 16, member 4
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR1B small proline-rich protein 1B
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STAB2 stabilin 2
STIM1 stromal interaction molecule 1
TMOD2 tropomodulin 2 (neuronal)
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
VIM vimentin
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
XYLT2 xylosyltransferase II
ZNF134 zinc finger protein 134
ZNF205 zinc finger protein 205
ZNF695 zinc finger protein 695