betahistine-6611 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the betahistine-6611 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADARB1 adenosine deaminase, RNA-specific, B1
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ARHGAP22 Rho GTPase activating protein 22
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BAAT bile acid CoA:amino acid N-acyltransferase
BMP8B bone morphogenetic protein 8b
BTG2 BTG family, member 2
C1ORF116 chromosome 1 open reading frame 116
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CASP4 caspase 4, apoptosis-related cysteine peptidase
CD300A CD300a molecule
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
DENND2A DENN/MADD domain containing 2A
DHODH dihydroorotate dehydrogenase (quinone)
DHRS9 dehydrogenase/reductase (SDR family) member 9
DLG3 discs, large homolog 3 (Drosophila)
DMP1 dentin matrix acidic phosphoprotein 1
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DOCK6 dedicator of cytokinesis 6
EDIL3 EGF-like repeats and discoidin I-like domains 3
EGR1 early growth response 1
EML2 echinoderm microtubule associated protein like 2
ERCC2 excision repair cross-complementation group 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FLT1 fms-related tyrosine kinase 1
FOLR2 folate receptor 2 (fetal)
FUS FUS RNA binding protein
GLB1L galactosidase, beta 1-like
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR182 G protein-coupled receptor 182
GRM6 glutamate receptor, metabotropic 6
HEMK1 HemK methyltransferase family member 1
HIPK3 homeodomain interacting protein kinase 3
HOXC10 homeobox C10
HOXC5 homeobox C5
ICA1 islet cell autoantigen 1, 69kDa
ICOSLG inducible T-cell co-stimulator ligand
IGFBP1 insulin-like growth factor binding protein 1
IL13 interleukin 13
KALRN kalirin, RhoGEF kinase
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCTD14 potassium channel tetramerization domain containing 14
KIDINS220 kinase D-interacting substrate, 220kDa
KIFC3 kinesin family member C3
KLK7 kallikrein-related peptidase 7
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRT7 keratin 7, type II
LOC57399 uncharacterized gastric protein ZA52P
LOX lysyl oxidase
LTBP4 latent transforming growth factor beta binding protein 4
LY6G6C lymphocyte antigen 6 complex, locus G6C
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MERTK MER proto-oncogene, tyrosine kinase
MTMR7 myotubularin related protein 7
NOL10 nucleolar protein 10
NPAS3 neuronal PAS domain protein 3
NPY6R neuropeptide Y receptor Y6 (pseudogene)
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PAPPA2 pappalysin 2
PAX2 paired box 2
PBOV1 prostate and breast cancer overexpressed 1
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PLK4 polo-like kinase 4
PODXL2 podocalyxin-like 2
POU6F1 POU class 6 homeobox 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PVR poliovirus receptor
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RUNDC3B RUN domain containing 3B
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAMD4A sterile alpha motif domain containing 4A
SELL selectin L
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SETD1A SET domain containing 1A
SIRT4 sirtuin 4
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SOS2 son of sevenless homolog 2 (Drosophila)
SPATA6 spermatogenesis associated 6
SPG20 spastic paraplegia 20 (Troyer syndrome)
SSTR4 somatostatin receptor 4
TEX13A testis expressed 13A
TLK1 tousled-like kinase 1
TMPRSS4 transmembrane protease, serine 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D2 TSC22 domain family, member 2
UPK2 uroplakin 2
WDR25 WD repeat domain 25
ZFPL1 zinc finger protein-like 1
ZNF215 zinc finger protein 215
ZNF235 zinc finger protein 235
ZNF254 zinc finger protein 254
ZNF573 zinc finger protein 573

decreased expression

Symbol Name
AGO4 argonaute RISC catalytic component 4
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
AP1B1 adaptor-related protein complex 1, beta 1 subunit
ARMCX4 armadillo repeat containing, X-linked 4
BAHCC1 BAH domain and coiled-coil containing 1
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CAPN15 calpain 15
CAPN5 calpain 5
CARD8 caspase recruitment domain family, member 8
CBX4 chromobox homolog 4
CCDC94 coiled-coil domain containing 94
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDH7 cadherin 7, type 2
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPPED1 calcineurin-like phosphoesterase domain containing 1
CST1 cystatin SN
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYBRD1 cytochrome b reductase 1
DBF4B DBF4 zinc finger B
DEAF1 DEAF1 transcription factor
DLK2 delta-like 2 homolog (Drosophila)
DNAH17 dynein, axonemal, heavy chain 17
DSPP dentin sialophosphoprotein
DUSP8 dual specificity phosphatase 8
ERCC4 excision repair cross-complementation group 4
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FLT4 fms-related tyrosine kinase 4
FSD1 fibronectin type III and SPRY domain containing 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GMEB1 glucocorticoid modulatory element binding protein 1
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HAMP hepcidin antimicrobial peptide
HDAC7 histone deacetylase 7
HSPA1L heat shock 70kDa protein 1-like
IL7R interleukin 7 receptor
KIAA1456 KIAA1456
KIF13B kinesin family member 13B
KPNA5 karyopherin alpha 5 (importin alpha 6)
LAMC3 laminin, gamma 3
LINC00341 long intergenic non-protein coding RNA 341
LPAR4 lysophosphatidic acid receptor 4
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LYRM9 LYR motif containing 9
MAGEF1 melanoma antigen family F1
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MFSD6 major facilitator superfamily domain containing 6
MGP matrix Gla protein
MTG1 mitochondrial ribosome-associated GTPase 1
MXD3 MAX dimerization protein 3
NBEAL2 neurobeachin-like 2
NDP Norrie disease (pseudoglioma)
NKX3-2 NK3 homeobox 2
NTSR1 neurotensin receptor 1 (high affinity)
NUP62CL nucleoporin 62kDa C-terminal like
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLXNB3 plexin B3
POLL polymerase (DNA directed), lambda
PWAR5 Prader Willi/Angelman region RNA 5
RAB3B RAB3B, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAI2 retinoic acid induced 2
SCN10A sodium channel, voltage gated, type X alpha subunit
SIX3 SIX homeobox 3
SLC12A9 solute carrier family 12, member 9
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPAG7 sperm associated antigen 7
STARD3 StAR-related lipid transfer (START) domain containing 3
STX1A syntaxin 1A (brain)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNPO synaptopodin
TBC1D17 TBC1 domain family, member 17
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TM7SF3 transmembrane 7 superfamily member 3
TMEM212 transmembrane protein 212
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRAIP TRAF interacting protein
TRIM66 tripartite motif containing 66
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TRPV6 transient receptor potential cation channel, subfamily V, member 6
UNC119 unc-119 homolog (C. elegans)
USB1 U6 snRNA biogenesis 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VARS valyl-tRNA synthetase
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB22 zinc finger and BTB domain containing 22
ZNF385D zinc finger protein 385D
ZNF428 zinc finger protein 428
ZNF510 zinc finger protein 510
ZNF574 zinc finger protein 574