betahistine-4956 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the betahistine-4956 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACO2 aconitase 2, mitochondrial
AHI1 Abelson helper integration site 1
AIF1 allograft inflammatory factor 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ASPN asporin
BBC3 BCL2 binding component 3
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF1 chromosome 14 open reading frame 1
C1QTNF1 C1q and tumor necrosis factor related protein 1
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C21ORF2 chromosome 21 open reading frame 2
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CD6 CD6 molecule
CD82 CD82 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLDN16 claudin 16
CRTC1 CREB regulated transcription coactivator 1
CRY2 cryptochrome circadian clock 2
CSF1 colony stimulating factor 1 (macrophage)
DFNA5 deafness, autosomal dominant 5
DIO2 deiodinase, iodothyronine, type II
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DOCK1 dedicator of cytokinesis 1
EDNRB endothelin receptor type B
EXOSC1 exosome component 1
FAM131A family with sequence similarity 131, member A
FAM46C family with sequence similarity 46, member C
FSCN1 fascin actin-bundling protein 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GPR1 G protein-coupled receptor 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HGD homogentisate 1,2-dioxygenase
HOXB2 homeobox B2
HOXB5 homeobox B5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HUS1 HUS1 checkpoint homolog (S. pombe)
IDS iduronate 2-sulfatase
IL21 interleukin 21
INPP5J inositol polyphosphate-5-phosphatase J
ISL1 ISL LIM homeobox 1
JPH3 junctophilin 3
JRK Jrk homolog (mouse)
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KRT19P2 keratin 19 pseudogene 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARK4 MAP/microtubule affinity-regulating kinase 4
MFGE8 milk fat globule-EGF factor 8 protein
MRPS18C mitochondrial ribosomal protein S18C
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MX1 MX dynamin-like GTPase 1
NKTR natural killer cell triggering receptor
NOP16 NOP16 nucleolar protein
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
OLFML2A olfactomedin-like 2A
OVOL1 ovo-like zinc finger 1
PKNOX2 PBX/knotted 1 homeobox 2
PRB1 proline-rich protein BstNI subfamily 1
PRELP proline/arginine-rich end leucine-rich repeat protein
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RHBG Rh family, B glycoprotein (gene/pseudogene)
RPS4Y1 ribosomal protein S4, Y-linked 1
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIM2 single-minded family bHLH transcription factor 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SPAG4 sperm associated antigen 4
SSX3 synovial sarcoma, X breakpoint 3
STX7 syntaxin 7
TBX3 T-box 3
TCP11L1 t-complex 11, testis-specific-like 1
TECTA tectorin alpha
THBD thrombomodulin
TLR5 toll-like receptor 5
TMEM144 transmembrane protein 144
TRIM29 tripartite motif containing 29
TTC9 tetratricopeptide repeat domain 9
VIPR2 vasoactive intestinal peptide receptor 2
VN1R1 vomeronasal 1 receptor 1
VWA5A von Willebrand factor A domain containing 5A
WSCD1 WSC domain containing 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF223 zinc finger protein 223
ZNF44 zinc finger protein 44
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ABHD17A abhydrolase domain containing 17A
ADCY6 adenylate cyclase 6
AKIP1 A kinase (PRKA) interacting protein 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALPK1 alpha-kinase 1
BCAS4 breast carcinoma amplified sequence 4
C19ORF40 chromosome 19 open reading frame 40
CASD1 CAS1 domain containing 1
CBR1 carbonyl reductase 1
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CFD complement factor D (adipsin)
CHST10 carbohydrate sulfotransferase 10
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CIDEC cell death-inducing DFFA-like effector c
CLDN15 claudin 15
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CNPY3 canopy FGF signaling regulator 3
CORO1A coronin, actin binding protein, 1A
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXORF40A chromosome X open reading frame 40A
CYB5R1 cytochrome b5 reductase 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DVL1 dishevelled segment polarity protein 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA3 ephrin-A3
EIF6 eukaryotic translation initiation factor 6
ENO2 enolase 2 (gamma, neuronal)
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM127B family with sequence similarity 127, member B
FAM86C1 family with sequence similarity 86, member C1
FBXL6 F-box and leucine-rich repeat protein 6
GBP2 guanylate binding protein 2, interferon-inducible
GOLGA8B golgin A8 family, member B
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HAUS4 HAUS augmin-like complex, subunit 4
HOXC13 homeobox C13
HP1BP3 heterochromatin protein 1, binding protein 3
ICT1 immature colon carcinoma transcript 1
IFI27 interferon, alpha-inducible protein 27
IFITM3 interferon induced transmembrane protein 3
IL17RA interleukin 17 receptor A
INCENP inner centromere protein antigens 135/155kDa
IRAK4 interleukin-1 receptor-associated kinase 4
KLHL28 kelch-like family member 28
LMNB1 lamin B1
MAPK3 mitogen-activated protein kinase 3
MECR mitochondrial trans-2-enoyl-CoA reductase
MEIS1 Meis homeobox 1
MOGS mannosyl-oligosaccharide glucosidase
MON1B MON1 secretory trafficking family member B
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NABP2 nucleic acid binding protein 2
NBAS neuroblastoma amplified sequence
NEK11 NIMA-related kinase 11
NPIPB15 nuclear pore complex interacting protein family, member B15
NPY1R neuropeptide Y receptor Y1
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PARP16 poly (ADP-ribose) polymerase family, member 16
PC pyruvate carboxylase
PCYOX1L prenylcysteine oxidase 1 like
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCD1 phospholipase C, delta 1
PLD3 phospholipase D family, member 3
POLE polymerase (DNA directed), epsilon, catalytic subunit
POMZP3 POM121 and ZP3 fusion
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RGS17 regulator of G-protein signaling 17
RNF123 ring finger protein 123
RPL13P5 ribosomal protein L13 pseudogene 5
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SERTAD3 SERTA domain containing 3
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SOWAHC sosondowah ankyrin repeat domain family member C
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STX1A syntaxin 1A (brain)
SYNGR3 synaptogyrin 3
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TEX264 testis expressed 264
TMEM109 transmembrane protein 109
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TPRA1 transmembrane protein, adipocyte asscociated 1
TRIM25 tripartite motif containing 25
TSPAN1 tetraspanin 1
VAX2 ventral anterior homeobox 2
XYLT2 xylosyltransferase II
ZC3H3 zinc finger CCCH-type containing 3
ZNF212 zinc finger protein 212
ZNF365 zinc finger protein 365
ZNF510 zinc finger protein 510
ZNF668 zinc finger protein 668