betahistine-2833 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the betahistine-2833 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK2 aarF domain containing kinase 2
ADRBK1 adrenergic, beta, receptor kinase 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ASB1 ankyrin repeat and SOCS box containing 1
ASIC3 acid sensing (proton gated) ion channel 3
ATP10B ATPase, class V, type 10B
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BAIAP2 BAI1-associated protein 2
BAIAP3 BAI1-associated protein 3
C1ORF105 chromosome 1 open reading frame 105
C3ORF18 chromosome 3 open reading frame 18
CDC25C cell division cycle 25C
CFAP45 cilia and flagella associated protein 45
COL6A1 collagen, type VI, alpha 1
CRMP1 collapsin response mediator protein 1
CUL3 cullin 3
CXCR4 chemokine (C-X-C motif) receptor 4
DIO2 deiodinase, iodothyronine, type II
EPHB2 EPH receptor B2
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
F13A1 coagulation factor XIII, A1 polypeptide
FGD1 FYVE, RhoGEF and PH domain containing 1
FLOT1 flotillin 1
FN1 fibronectin 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
GSK3A glycogen synthase kinase 3 alpha
GSTTP1 glutathione S-transferase theta pseudogene 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IFNA4 interferon, alpha 4
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL11 interleukin 11
IL1B interleukin 1, beta
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IQCA1 IQ motif containing with AAA domain 1
ITGB5 integrin, beta 5
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KDM8 lysine (K)-specific demethylase 8
KEL Kell blood group, metallo-endopeptidase
LAMB3 laminin, beta 3
LIF leukemia inhibitory factor
LRRC48 leucine rich repeat containing 48
LTBP2 latent transforming growth factor beta binding protein 2
LTBP4 latent transforming growth factor beta binding protein 4
MAPK10 mitogen-activated protein kinase 10
MARK4 MAP/microtubule affinity-regulating kinase 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFSD7 major facilitator superfamily domain containing 7
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MLXIP MLX interacting protein
MXD4 MAX dimerization protein 4
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NCOA2 nuclear receptor coactivator 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PCDH1 protocadherin 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PGLYRP4 peptidoglycan recognition protein 4
PHF20 PHD finger protein 20
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POM121L2 POM121 transmembrane nucleoporin-like 2
PRF1 perforin 1 (pore forming protein)
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPH3AL rabphilin 3A-like (without C2 domains)
SIVA1 SIVA1, apoptosis-inducing factor
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLPI secretory leukocyte peptidase inhibitor
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOAT2 sterol O-acyltransferase 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STAB1 stabilin 1
STAB2 stabilin 2
SUGP1 SURP and G patch domain containing 1
TBX5 T-box 5
TDRKH tudor and KH domain containing
TLE2 transducin-like enhancer of split 2
TLR2 toll-like receptor 2
TONSL tonsoku-like, DNA repair protein
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAK1 trafficking protein, kinesin binding 1
TUBA3C tubulin, alpha 3c
VIPR1 vasoactive intestinal peptide receptor 1
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WDTC1 WD and tetratricopeptide repeats 1
ZBTB17 zinc finger and BTB domain containing 17
ZNF614 zinc finger protein 614
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ASB9 ankyrin repeat and SOCS box containing 9
BATF basic leucine zipper transcription factor, ATF-like
BCL9 B-cell CLL/lymphoma 9
BGLAP bone gamma-carboxyglutamate (gla) protein
C11ORF80 chromosome 11 open reading frame 80
CAPN15 calpain 15
CCP110 centriolar coiled coil protein 110kDa
CGREF1 cell growth regulator with EF-hand domain 1
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CPPED1 calcineurin-like phosphoesterase domain containing 1
CUEDC1 CUE domain containing 1
DCAF13 DDB1 and CUL4 associated factor 13
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNA2 DNA replication helicase/nuclease 2
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DSCAM Down syndrome cell adhesion molecule
ECHDC1 ethylmalonyl-CoA decarboxylase 1
EPPK1 epiplakin 1
ERCC4 excision repair cross-complementation group 4
F2R coagulation factor II (thrombin) receptor
FBRS fibrosin
FLRT3 fibronectin leucine rich transmembrane protein 3
GK3P glycerol kinase 3 pseudogene
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HOXC13 homeobox C13
HP1BP3 heterochromatin protein 1, binding protein 3
HYI hydroxypyruvate isomerase (putative)
ICK intestinal cell (MAK-like) kinase
IGFBP6 insulin-like growth factor binding protein 6
IREB2 iron-responsive element binding protein 2
KIAA0319L KIAA0319-like
KLHL25 kelch-like family member 25
L2HGDH L-2-hydroxyglutarate dehydrogenase
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LMNB1 lamin B1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGOHB mago-nashi homolog B (Drosophila)
MED18 mediator complex subunit 18
MIS18BP1 MIS18 binding protein 1
MYO1E myosin IE
NPIPB3 nuclear pore complex interacting protein family, member B3
NPY1R neuropeptide Y receptor Y1
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PELI1 pellino E3 ubiquitin protein ligase 1
PHEX phosphate regulating endopeptidase homolog, X-linked
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PITX2 paired-like homeodomain 2
POLH polymerase (DNA directed), eta
POLL polymerase (DNA directed), lambda
PRPH peripherin
RAB27B RAB27B, member RAS oncogene family
RBBP5 retinoblastoma binding protein 5
RFX7 regulatory factor X, 7
RLN2 relaxin 2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPAP2 RNA polymerase II associated protein 2
RPL13P5 ribosomal protein L13 pseudogene 5
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIRT2 sirtuin 2
SLC12A8 solute carrier family 12, member 8
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SNX16 sorting nexin 16
SPIDR scaffolding protein involved in DNA repair
SRPX sushi-repeat containing protein, X-linked
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYBU syntabulin (syntaxin-interacting)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX19 T-box 19
TMEM120B transmembrane protein 120B
TMEM159 transmembrane protein 159
TOLLIP toll interacting protein
TPCN1 two pore segment channel 1
TRAIP TRAF interacting protein
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
VASH2 vasohibin 2
VGF VGF nerve growth factor inducible
WDR25 WD repeat domain 25
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XYLT2 xylosyltransferase II
ZBTB6 zinc finger and BTB domain containing 6
ZNF250 zinc finger protein 250
ZNF324 zinc finger protein 324
ZNF492 zinc finger protein 492
ZNF669 zinc finger protein 669
ZNF721 zinc finger protein 721
ZNF787 zinc finger protein 787
ZNF816 zinc finger protein 816