betahistine-2472 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the betahistine-2472 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACVR1B activin A receptor, type IB
ADARB1 adenosine deaminase, RNA-specific, B1
ADGRB1 adhesion G protein-coupled receptor B1
AIM1L absent in melanoma 1-like
AKAP13 A kinase (PRKA) anchor protein 13
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ANGPTL2 angiopoietin-like 2
APOE apolipoprotein E
ARHGAP26 Rho GTPase activating protein 26
ATF7 activating transcription factor 7
BEGAIN brain-enriched guanylate kinase-associated
C21ORF2 chromosome 21 open reading frame 2
CDC42 cell division cycle 42
CHI3L2 chitinase 3-like 2
CLEC4E C-type lectin domain family 4, member E
CLMN calmin (calponin-like, transmembrane)
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNIH3 cornichon family AMPA receptor auxiliary protein 3
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CPLX2 complexin 2
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CUL2 cullin 2
CUL7 cullin 7
DACH1 dachshund family transcription factor 1
DCLK2 doublecortin-like kinase 2
DGKE diacylglycerol kinase, epsilon 64kDa
DHRS12 dehydrogenase/reductase (SDR family) member 12
DUSP4 dual specificity phosphatase 4
EFNA4 ephrin-A4
EFR3B EFR3 homolog B (S. cerevisiae)
FAM162A family with sequence similarity 162, member A
FBXO4 F-box protein 4
FLOT1 flotillin 1
FRZB frizzled-related protein
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAN gigaxonin
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPR35 G protein-coupled receptor 35
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HOXC11 homeobox C11
IGLJ3 immunoglobulin lambda joining 3
IL6ST interleukin 6 signal transducer
IMPG2 interphotoreceptor matrix proteoglycan 2
JAK3 Janus kinase 3
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LOC647070 uncharacterized LOC647070
MAP7 microtubule-associated protein 7
MAX MYC associated factor X
MBNL2 muscleblind-like splicing regulator 2
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MYT1 myelin transcription factor 1
NCKIPSD NCK interacting protein with SH3 domain
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PCDHGA10 protocadherin gamma subfamily A, 10
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PDLIM5 PDZ and LIM domain 5
PDLIM7 PDZ and LIM domain 7 (enigma)
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLK3 polo-like kinase 3
PLSCR3 phospholipid scramblase 3
RAB11B RAB11B, member RAS oncogene family
RB1 retinoblastoma 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RUFY3 RUN and FYVE domain containing 3
SCN10A sodium channel, voltage gated, type X alpha subunit
SIPA1L1 signal-induced proliferation-associated 1 like 1
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SMAD5 SMAD family member 5
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SNED1 sushi, nidogen and EGF-like domains 1
SNW1 SNW domain containing 1
SPDEF SAM pointed domain containing ETS transcription factor
SPPL2B signal peptide peptidase like 2B
SSTR5 somatostatin receptor 5
STS steroid sulfatase (microsomal), isozyme S
TAS2R1 taste receptor, type 2, member 1
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TMEM180 transmembrane protein 180
TMEM2 transmembrane protein 2
TRIO trio Rho guanine nucleotide exchange factor
TTC38 tetratricopeptide repeat domain 38
ULBP2 UL16 binding protein 2
ZFP64 ZFP64 zinc finger protein
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF702P zinc finger protein 702, pseudogene

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACO1 aconitase 1, soluble
ADGRE1 adhesion G protein-coupled receptor E1
ADGRL3 adhesion G protein-coupled receptor L3
AGO4 argonaute RISC catalytic component 4
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALS2CL ALS2 C-terminal like
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BPHL biphenyl hydrolase-like (serine hydrolase)
C17ORF70 chromosome 17 open reading frame 70
CBX4 chromobox homolog 4
CDC37L1 cell division cycle 37-like 1
CENPT centromere protein T
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLCN2 chloride channel, voltage-sensitive 2
CPTP ceramide-1-phosphate transfer protein
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOK3 docking protein 3
DPEP2 dipeptidase 2
DSPP dentin sialophosphoprotein
DUSP8 dual specificity phosphatase 8
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EML4 echinoderm microtubule associated protein like 4
EPS8 epidermal growth factor receptor pathway substrate 8
ERCC6 excision repair cross-complementation group 6
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM188A family with sequence similarity 188, member A
FBRS fibrosin
FBXL6 F-box and leucine-rich repeat protein 6
FBXO31 F-box protein 31
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGGY FGGY carbohydrate kinase domain containing
FLT4 fms-related tyrosine kinase 4
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GALK1 galactokinase 1
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GRIP2 glutamate receptor interacting protein 2
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HPSE heparanase
HRH2 histamine receptor H2
IL3RA interleukin 3 receptor, alpha (low affinity)
INO80D INO80 complex subunit D
IQCG IQ motif containing G
IRS1 insulin receptor substrate 1
KIAA1107 KIAA1107
LIN7B lin-7 homolog B (C. elegans)
LRRK1 leucine-rich repeat kinase 1
LTC4S leukotriene C4 synthase
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAGEF1 melanoma antigen family F1
MAGOHB mago-nashi homolog B (Drosophila)
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MRAS muscle RAS oncogene homolog
NACA2 nascent polypeptide-associated complex alpha subunit 2
NSUN6 NOP2/Sun domain family, member 6
NXPE3 neurexophilin and PC-esterase domain family, member 3
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PGM3 phosphoglucomutase 3
PIPOX pipecolic acid oxidase
PIR pirin (iron-binding nuclear protein)
PITX2 paired-like homeodomain 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCD1 phospholipase C, delta 1
POLL polymerase (DNA directed), lambda
POMT1 protein-O-mannosyltransferase 1
POTEKP POTE ankyrin domain family, member K, pseudogene
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
QTRT1 queuine tRNA-ribosyltransferase 1
RAB17 RAB17, member RAS oncogene family
RAB8B RAB8B, member RAS oncogene family
REC8 REC8 meiotic recombination protein
RNF126P1 ring finger protein 126 pseudogene 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SIL1 SIL1 nucleotide exchange factor
SIRT6 sirtuin 6
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPINT1 serine peptidase inhibitor, Kunitz type 1
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
TBC1D19 TBC1 domain family, member 19
TBCCD1 TBCC domain containing 1
THEM6 thioesterase superfamily member 6
TIGD6 tigger transposable element derived 6
TMEM209 transmembrane protein 209
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
UPK3A uroplakin 3A
XAB2 XPA binding protein 2
XYLT2 xylosyltransferase II
ZBTB22 zinc finger and BTB domain containing 22
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF345 zinc finger protein 345
ZNF76 zinc finger protein 76