beta-escin-4544 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the beta-escin-4544 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
C1ORF116 chromosome 1 open reading frame 116
C3ORF52 chromosome 3 open reading frame 52
CACFD1 calcium channel flower domain containing 1
CCL20 chemokine (C-C motif) ligand 20
CD83 CD83 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CISH cytokine inducible SH2-containing protein
CLDN1 claudin 1
CTH cystathionine gamma-lyase
CTNS cystinosin, lysosomal cystine transporter
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EGR1 early growth response 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FERMT2 fermitin family member 2
FGF5 fibroblast growth factor 5
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GK glycerol kinase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRAMD1C GRAM domain containing 1C
GREB1L growth regulation by estrogen in breast cancer-like
GTPBP1 GTP binding protein 1
HBB hemoglobin, beta
HIST1H1D histone cluster 1, H1d
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HIST1H4H histone cluster 1, H4h
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IDI2-AS1 IDI2 antisense RNA 1
IL11 interleukin 11
IL1RL1 interleukin 1 receptor-like 1
IL24 interleukin 24
IL6 interleukin 6
INHBA inhibin, beta A
JUN jun proto-oncogene
KHSRP KH-type splicing regulatory protein
KLF6 Kruppel-like factor 6
KRT17 keratin 17, type I
KRT34 keratin 34, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEGF9 multiple EGF-like-domains 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGF nerve growth factor (beta polypeptide)
NOVA2 neuro-oncological ventral antigen 2
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCDHB3 protocadherin beta 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PVT1 Pvt1 oncogene (non-protein coding)
RGS3 regulator of G-protein signaling 3
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RND1 Rho family GTPase 1
RND3 Rho family GTPase 3
RNGTT RNA guanylyltransferase and 5'-phosphatase
RPL35A ribosomal protein L35a
SAT1 spermidine/spermine N1-acetyltransferase 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SMG7 SMG7 nonsense mediated mRNA decay factor
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
STC2 stanniocalcin 2
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TCP11L1 t-complex 11, testis-specific-like 1
TGFB2 transforming growth factor, beta 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNK2 tyrosine kinase, non-receptor, 2
TOP3B topoisomerase (DNA) III beta
XDH xanthine dehydrogenase
ZBTB10 zinc finger and BTB domain containing 10
ZCCHC14 zinc finger, CCHC domain containing 14
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AKIP1 A kinase (PRKA) interacting protein 1
AMDHD2 amidohydrolase domain containing 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASPHD1 aspartate beta-hydroxylase domain containing 1
BAAT bile acid CoA:amino acid N-acyltransferase
BTF3P12 basic transcription factor 3 pseudogene 12
C1ORF112 chromosome 1 open reading frame 112
C1S complement component 1, s subcomponent
C9ORF40 chromosome 9 open reading frame 40
CBX7 chromobox homolog 7
CBY1 chibby homolog 1 (Drosophila)
CCNA1 cyclin A1
CCNJ cyclin J
CDH10 cadherin 10, type 2 (T2-cadherin)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLIP4 CAP-GLY domain containing linker protein family, member 4
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNN2 calponin 2
CNTNAP3B contactin associated protein-like 3B
CORO1A coronin, actin binding protein, 1A
CPNE7 copine VII
CSRNP3 cysteine-serine-rich nuclear protein 3
CTSO cathepsin O
CYBRD1 cytochrome b reductase 1
DNAH7 dynein, axonemal, heavy chain 7
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EFNB1 ephrin-B1
EHD3 EH-domain containing 3
ELP6 elongator acetyltransferase complex subunit 6
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM127B family with sequence similarity 127, member B
FOXN2 forkhead box N2
GJC1 gap junction protein, gamma 1, 45kDa
GLI3 GLI family zinc finger 3
GLS2 glutaminase 2 (liver, mitochondrial)
GLT8D2 glycosyltransferase 8 domain containing 2
GPATCH3 G patch domain containing 3
GPX2 glutathione peroxidase 2
GRPR gastrin-releasing peptide receptor
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AK histone cluster 1, H2ak
HOXA1 homeobox A1
HOXB13 homeobox B13
HYAL2 hyaluronoglucosaminidase 2
ICK intestinal cell (MAK-like) kinase
IQCG IQ motif containing G
IQSEC2 IQ motif and Sec7 domain 2
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM5C lysine (K)-specific demethylase 5C
KRT8P12 keratin 8 pseudogene 12
LRP3 low density lipoprotein receptor-related protein 3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAGEF1 melanoma antigen family F1
MGP matrix Gla protein
MUC3B mucin 3B, cell surface associated
NDP Norrie disease (pseudoglioma)
NDRG4 NDRG family member 4
NME5 NME/NM23 family member 5
NOD1 nucleotide-binding oligomerization domain containing 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
OSMR oncostatin M receptor
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PARD6A par-6 family cell polarity regulator alpha
PLCD1 phospholipase C, delta 1
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRB3 proline-rich protein BstNI subfamily 3
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRSS53 protease, serine, 53
SCAMP5 secretory carrier membrane protein 5
SHROOM2 shroom family member 2
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STAG3 stromal antigen 3
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TBX19 T-box 19
TENM4 teneurin transmembrane protein 4
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
UGT8 UDP glycosyltransferase 8
YPEL1 yippee-like 1 (Drosophila)
ZBTB22 zinc finger and BTB domain containing 22
ZNF324 zinc finger protein 324
ZNF37BP zinc finger protein 37B, pseudogene
ZNF446 zinc finger protein 446
ZNF747 zinc finger protein 747
ZNF768 zinc finger protein 768
ZNF816 zinc finger protein 816