beta-escin-4364 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the beta-escin-4364 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ADCK4 aarF domain containing kinase 4
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATF7IP activating transcription factor 7 interacting protein
ATP10B ATPase, class V, type 10B
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BDKRB2 bradykinin receptor B2
BIRC3 baculoviral IAP repeat containing 3
C11ORF30 chromosome 11 open reading frame 30
C17ORF53 chromosome 17 open reading frame 53
C1RL complement component 1, r subcomponent-like
CCKBR cholecystokinin B receptor
CD2 CD2 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMIP cell migration inducing protein, hyaluronan binding
CGA glycoprotein hormones, alpha polypeptide
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CLCA1 chloride channel accessory 1
CLTA clathrin, light chain A
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CORO2B coronin, actin binding protein, 2B
CPA4 carboxypeptidase A4
CRMP1 collapsin response mediator protein 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
EHF ets homologous factor
ELN elastin
ELOVL5 ELOVL fatty acid elongase 5
EPS8L3 EPS8-like 3
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GEM GTP binding protein overexpressed in skeletal muscle
GRIK2 glutamate receptor, ionotropic, kainate 2
HIST1H2AB histone cluster 1, H2ab
ICOS inducible T-cell co-stimulator
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL10 interleukin 10
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
INSR insulin receptor
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
IZUMO4 IZUMO family member 4
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLF12 Kruppel-like factor 12
KLF13 Kruppel-like factor 13
LIF leukemia inhibitory factor
LOC51145 uncharacterized LOC51145
LTB4R leukotriene B4 receptor
MATN1 matrilin 1, cartilage matrix protein
MAU2 MAU2 sister chromatid cohesion factor
MOBP myelin-associated oligodendrocyte basic protein
MORN1 MORN repeat containing 1
MTNR1A melatonin receptor 1A
MXD4 MAX dimerization protein 4
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PBX2 pre-B-cell leukemia homeobox 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLK3 polo-like kinase 3
PLTP phospholipid transfer protein
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RAP1GAP RAP1 GTPase activating protein
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SERHL2 serine hydrolase-like 2
SHOX2 short stature homeobox 2
SLC43A3 solute carrier family 43, member 3
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SPON1 spondin 1, extracellular matrix protein
SPRR1A small proline-rich protein 1A
SVIL supervillin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
VCAN versican
WSCD1 WSC domain containing 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZG16 zymogen granule protein 16
ZNF222 zinc finger protein 222

decreased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ALS2CL ALS2 C-terminal like
ARC activity-regulated cytoskeleton-associated protein
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ASAP1-IT1 ASAP1 intronic transcript 1
BLNK B-cell linker
C14ORF79 chromosome 14 open reading frame 79
C1ORF54 chromosome 1 open reading frame 54
C1QB complement component 1, q subcomponent, B chain
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CA5BP1 carbonic anhydrase VB pseudogene 1
CD83 CD83 molecule
CDADC1 cytidine and dCMP deaminase domain containing 1
CDH18 cadherin 18, type 2
CFHR4 complement factor H-related 4
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCN6 chloride channel, voltage-sensitive 6
CNTFR ciliary neurotrophic factor receptor
CORT cortistatin
CPNE7 copine VII
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBF4B DBF4 zinc finger B
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DEPDC5 DEP domain containing 5
DMTN dematin actin binding protein
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DTX2 deltex 2, E3 ubiquitin ligase
ELSPBP1 epididymal sperm binding protein 1
EPHX2 epoxide hydrolase 2, cytoplasmic
ERO1LB ERO1-like beta (S. cerevisiae)
ETV6 ets variant 6
FAM120C family with sequence similarity 120C
FBXO2 F-box protein 2
FLRT3 fibronectin leucine rich transmembrane protein 3
GFI1 growth factor independent 1 transcription repressor
GMPR guanosine monophosphate reductase
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRAMD1C GRAM domain containing 1C
HDAC7 histone deacetylase 7
HIST1H2AK histone cluster 1, H2ak
HOXA4 homeobox A4
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IDI2-AS1 IDI2 antisense RNA 1
IFT81 intraflagellar transport 81
IPO8 importin 8
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KLF2 Kruppel-like factor 2
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LOC390998 ribosomal protein L10 pseudogene
LOC730101 uncharacterized LOC730101
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAST3 microtubule associated serine/threonine kinase 3
MTCP1 mature T-cell proliferation 1
NAT6 N-acetyltransferase 6 (GCN5-related)
NDE1 nudE neurodevelopment protein 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NKAIN1 Na+/K+ transporting ATPase interacting 1
OLFML2A olfactomedin-like 2A
OPLAH 5-oxoprolinase (ATP-hydrolysing)
PAIP2B poly(A) binding protein interacting protein 2B
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDHB13 protocadherin beta 13
PCDHB3 protocadherin beta 3
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PLD3 phospholipase D family, member 3
POU3F2 POU class 3 homeobox 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PSCA prostate stem cell antigen
QPCT glutaminyl-peptide cyclotransferase
RAB36 RAB36, member RAS oncogene family
RNF126P1 ring finger protein 126 pseudogene 1
RNF208 ring finger protein 208
RPGR retinitis pigmentosa GTPase regulator
RPL10L ribosomal protein L10-like
SAYSD1 SAYSVFN motif domain containing 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SETD8 SET domain containing (lysine methyltransferase) 8
SGCE sarcoglycan, epsilon
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLMO1 slowmo homolog 1 (Drosophila)
SOAT2 sterol O-acyltransferase 2
SYNC syncoilin, intermediate filament protein
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TET3 tet methylcytosine dioxygenase 3
TEX14 testis expressed 14
TLR5 toll-like receptor 5
TPSG1 tryptase gamma 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TUBA4B tubulin, alpha 4b
ZFP37 ZFP37 zinc finger protein
ZNF134 zinc finger protein 134
ZNF37BP zinc finger protein 37B, pseudogene
ZNF862 zinc finger protein 862
ZSWIM1 zinc finger, SWIM-type containing 1