beta-escin-2194 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the beta-escin-2194 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APOE apolipoprotein E
ASB9 ankyrin repeat and SOCS box containing 9
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B9D1 B9 protein domain 1
BIN1 bridging integrator 1
C17ORF59 chromosome 17 open reading frame 59
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CD68 CD68 molecule
CD80 CD80 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CHPF chondroitin polymerizing factor
CLDN7 claudin 7
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CPEB3 cytoplasmic polyadenylation element binding protein 3
CREM cAMP responsive element modulator
DDAH2 dimethylarginine dimethylaminohydrolase 2
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DTX2 deltex 2, E3 ubiquitin ligase
ELL elongation factor RNA polymerase II
EPHB2 EPH receptor B2
EXOSC2 exosome component 2
FBXL2 F-box and leucine-rich repeat protein 2
FKBP8 FK506 binding protein 8, 38kDa
FMO5 flavin containing monooxygenase 5
FOXA1 forkhead box A1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA2 GATA binding protein 2
HCFC1 host cell factor C1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOXA1 homeobox A1
HOXA9 homeobox A9
HOXB9 homeobox B9
HYAL3 hyaluronoglucosaminidase 3
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IFNA16 interferon, alpha 16
IL24 interleukin 24
IRF5 interferon regulatory factor 5
ISG20 interferon stimulated exonuclease gene 20kDa
KIF1C kinesin family member 1C
KIF25-AS1 KIF25 antisense RNA 1
KLF6 Kruppel-like factor 6
LAMB2 laminin, beta 2 (laminin S)
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LIMD1 LIM domains containing 1
LMF1 lipase maturation factor 1
LMF2 lipase maturation factor 2
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MX1 MX dynamin-like GTPase 1
MXD4 MAX dimerization protein 4
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYO9B myosin IXB
MYOM1 myomesin 1
NOD2 nucleotide-binding oligomerization domain containing 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCDHGA8 protocadherin gamma subfamily A, 8
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE4A phosphodiesterase 4A, cAMP-specific
PDE4C phosphodiesterase 4C, cAMP-specific
PDGFB platelet-derived growth factor beta polypeptide
PICALM phosphatidylinositol binding clathrin assembly protein
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLK3 polo-like kinase 3
PPP1R26 protein phosphatase 1, regulatory subunit 26
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCH protein kinase C, eta
PSG4 pregnancy specific beta-1-glycoprotein 4
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTCRA pre T-cell antigen receptor alpha
PYGB phosphorylase, glycogen; brain
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
SHOX2 short stature homeobox 2
SIT1 signaling threshold regulating transmembrane adaptor 1
SLAMF7 SLAM family member 7
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SOX13 SRY (sex determining region Y)-box 13
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPRR2B small proline-rich protein 2B
SSTR4 somatostatin receptor 4
TBX6 T-box 6
TGM2 transglutaminase 2
TLDC1 TBC/LysM-associated domain containing 1
TMPRSS15 transmembrane protease, serine 15
TP53I11 tumor protein p53 inducible protein 11
TROVE2 TROVE domain family, member 2
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VEZT vezatin, adherens junctions transmembrane protein
ZC3H7B zinc finger CCCH-type containing 7B
ZER1 zyg-11 related, cell cycle regulator
ZIC3 Zic family member 3
ZNF518A zinc finger protein 518A
ZNF696 zinc finger protein 696
ZNF749 zinc finger protein 749

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADORA3 adenosine A3 receptor
ARL15 ADP-ribosylation factor-like 15
ARSB arylsulfatase B
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BANK1 B-cell scaffold protein with ankyrin repeats 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BIK BCL2-interacting killer (apoptosis-inducing)
CA5BP1 carbonic anhydrase VB pseudogene 1
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CCDC71 coiled-coil domain containing 71
CD9 CD9 molecule
CDA cytidine deaminase
CDK3 cyclin-dependent kinase 3
CFAP44 cilia and flagella associated protein 44
CLCN2 chloride channel, voltage-sensitive 2
CNR2 cannabinoid receptor 2 (macrophage)
CRYL1 crystallin, lambda 1
CTSL cathepsin L
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
CYSLTR1 cysteinyl leukotriene receptor 1
DGKG diacylglycerol kinase, gamma 90kDa
DHRS11 dehydrogenase/reductase (SDR family) member 11
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EIF5A2 eukaryotic translation initiation factor 5A2
EXOC5 exocyst complex component 5
FAM127B family with sequence similarity 127, member B
FHIT fragile histidine triad
FOXN2 forkhead box N2
GALE UDP-galactose-4-epimerase
GALK1 galactokinase 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLCE glucuronic acid epimerase
GMPPA GDP-mannose pyrophosphorylase A
GNA13 guanine nucleotide binding protein (G protein), alpha 13
HHLA3 HERV-H LTR-associating 3
HIST1H1T histone cluster 1, H1t
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BC histone cluster 1, H2bc
IFI6 interferon, alpha-inducible protein 6
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL22 interleukin 22
INA internexin neuronal intermediate filament protein, alpha
IQCC IQ motif containing C
KCTD20 potassium channel tetramerization domain containing 20
KIF17 kinesin family member 17
KPNA5 karyopherin alpha 5 (importin alpha 6)
LIN7A lin-7 homolog A (C. elegans)
LPPR3 lipid phosphate phosphatase-related protein type 3
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK3 mitogen-activated protein kinase 3
MDM4 MDM4, p53 regulator
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MLPH melanophilin
NPFFR1 neuropeptide FF receptor 1
ODF2 outer dense fiber of sperm tails 2
PADI2 peptidyl arginine deiminase, type II
PCDHGB5 protocadherin gamma subfamily B, 5
PER3 period circadian clock 3
PEX13 peroxisomal biogenesis factor 13
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PKN1 protein kinase N1
PLP1 proteolipid protein 1
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PTPRS protein tyrosine phosphatase, receptor type, S
QPRT quinolinate phosphoribosyltransferase
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RABL6 RAB, member RAS oncogene family-like 6
RFXAP regulatory factor X-associated protein
RRAS related RAS viral (r-ras) oncogene homolog
RWDD3 RWD domain containing 3
SERGEF secretion regulating guanine nucleotide exchange factor
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SLC22A14 solute carrier family 22, member 14
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STRN striatin, calmodulin binding protein
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM254 transmembrane protein 254
TRAIP TRAF interacting protein
TRIM25 tripartite motif containing 25
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
YY2 YY2 transcription factor
ZC4H2 zinc finger, C4H2 domain containing
ZMAT5 zinc finger, matrin-type 5
ZNF10 zinc finger protein 10
ZNF155 zinc finger protein 155
ZNF225 zinc finger protein 225
ZNF665 zinc finger protein 665
ZNF701 zinc finger protein 701
ZNF816 zinc finger protein 816