beta-catenin destruction complex Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. (Gene Ontology, GO_0030877)
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10 proteins localized to the beta-catenin destruction complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SIAH1 siah E3 ubiquitin protein ligase 1 0.663342
CACYBP calcyclin binding protein 0.663342
AXIN1 axin 1 0.663342
GSK3B glycogen synthase kinase 3 beta 0.663342
GSK3A glycogen synthase kinase 3 alpha 0.663342
DACT1 dishevelled-binding antagonist of beta-catenin 1 0.663342
APC adenomatous polyposis coli 0.663342
AXIN2 axin 2 0.237908
CTNNBIP1 catenin, beta interacting protein 1 0.237908
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.237908