benzthiazide-4952 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the benzthiazide-4952 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGFG1 ArfGAP with FG repeats 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
APOE apolipoprotein E
APOL6 apolipoprotein L, 6
ARG1 arginase 1
ASPH aspartate beta-hydroxylase
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BMP6 bone morphogenetic protein 6
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
CD48 CD48 molecule
CD58 CD58 molecule
CD82 CD82 molecule
CEMP1 cementum protein 1
CLCN6 chloride channel, voltage-sensitive 6
CPA4 carboxypeptidase A4
CROCC ciliary rootlet coiled-coil, rootletin
CTNS cystinosin, lysosomal cystine transporter
CXORF21 chromosome X open reading frame 21
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DLG5 discs, large homolog 5 (Drosophila)
DLK2 delta-like 2 homolog (Drosophila)
DMP1 dentin matrix acidic phosphoprotein 1
DNAL4 dynein, axonemal, light chain 4
DOCK5 dedicator of cytokinesis 5
DOK4 docking protein 4
DSPP dentin sialophosphoprotein
EXOSC1 exosome component 1
FABP7 fatty acid binding protein 7, brain
FADS2 fatty acid desaturase 2
FADS3 fatty acid desaturase 3
FAIM2 Fas apoptotic inhibitory molecule 2
FAM134B family with sequence similarity 134, member B
FAM174B family with sequence similarity 174, member B
FAM46C family with sequence similarity 46, member C
FBXO21 F-box protein 21
FCGBP Fc fragment of IgG binding protein
FMO5 flavin containing monooxygenase 5
GP6 glycoprotein VI (platelet)
GPC3 glypican 3
HOMER3 homer scaffolding protein 3
HOXB2 homeobox B2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT27 intraflagellar transport 27
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA1109 KIAA1109
KIAA1462 KIAA1462
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KLHL25 kelch-like family member 25
LAMC3 laminin, gamma 3
LCMT2 leucine carboxyl methyltransferase 2
LIF leukemia inhibitory factor
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
LRP6 low density lipoprotein receptor-related protein 6
LSP1 lymphocyte-specific protein 1
MARK4 MAP/microtubule affinity-regulating kinase 4
MAST3 microtubule associated serine/threonine kinase 3
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
NDRG2 NDRG family member 2
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NLRX1 NLR family member X1
NOL10 nucleolar protein 10
NR2F1 nuclear receptor subfamily 2, group F, member 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARVA parvin, alpha
POU2F2 POU class 2 homeobox 2
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PRF1 perforin 1 (pore forming protein)
PTGDR prostaglandin D2 receptor (DP)
PTGIS prostaglandin I2 (prostacyclin) synthase
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RREB1 ras responsive element binding protein 1
RUNX1 runt-related transcription factor 1
SAFB scaffold attachment factor B
SAYSD1 SAYSVFN motif domain containing 1
SENP7 SUMO1/sentrin specific peptidase 7
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SGK2 serum/glucocorticoid regulated kinase 2
SIDT2 SID1 transmembrane family, member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STK11 serine/threonine kinase 11
SUGP1 SURP and G patch domain containing 1
SYMPK symplekin
TCP11L1 t-complex 11, testis-specific-like 1
TFDP3 transcription factor Dp family, member 3
THAP3 THAP domain containing, apoptosis associated protein 3
TM4SF5 transmembrane 4 L six family member 5
TP63 tumor protein p63
TPMT thiopurine S-methyltransferase
UBE2I ubiquitin-conjugating enzyme E2I
WIZ widely interspaced zinc finger motifs
ZER1 zyg-11 related, cell cycle regulator
ZFHX4 zinc finger homeobox 4
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP13A2 ATPase type 13A2
BAHCC1 BAH domain and coiled-coil containing 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BEX4 brain expressed, X-linked 4
C1ORF159 chromosome 1 open reading frame 159
C1ORF35 chromosome 1 open reading frame 35
C5 complement component 5
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAPRIN2 caprin family member 2
CCDC25 coiled-coil domain containing 25
CCS copper chaperone for superoxide dismutase
CHST10 carbohydrate sulfotransferase 10
CRELD1 cysteine-rich with EGF-like domains 1
CYB5R1 cytochrome b5 reductase 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNASE1L1 deoxyribonuclease I-like 1
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
DVL1 dishevelled segment polarity protein 1
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
ELMO3 engulfment and cell motility 3
EML4 echinoderm microtubule associated protein like 4
FAM160B2 family with sequence similarity 160, member B2
FAM222B family with sequence similarity 222, member B
FBXL2 F-box and leucine-rich repeat protein 2
FBXL6 F-box and leucine-rich repeat protein 6
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRS2 fibroblast growth factor receptor substrate 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GCHFR GTP cyclohydrolase I feedback regulator
GTF2I general transcription factor IIi
HELZ helicase with zinc finger
HIST1H1D histone cluster 1, H1d
HIST1H2AL histone cluster 1, H2al
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSPA1L heat shock 70kDa protein 1-like
IFI27 interferon, alpha-inducible protein 27
ITGA10 integrin, alpha 10
KCNK15 potassium channel, two pore domain subfamily K, member 15
KLHL28 kelch-like family member 28
KRT13 keratin 13, type I
LMNB1 lamin B1
LRP3 low density lipoprotein receptor-related protein 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MPDU1 mannose-P-dolichol utilization defect 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MVD mevalonate (diphospho) decarboxylase
MYL5 myosin, light chain 5, regulatory
NKAIN1 Na+/K+ transporting ATPase interacting 1
NOD1 nucleotide-binding oligomerization domain containing 1
NOL6 nucleolar protein 6 (RNA-associated)
NPIPB15 nuclear pore complex interacting protein family, member B15
NPM3 nucleophosmin/nucleoplasmin 3
NPTX1 neuronal pentraxin I
NT5DC3 5'-nucleotidase domain containing 3
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OTUD3 OTU deubiquitinase 3
PAIP2B poly(A) binding protein interacting protein 2B
PCDHA9 protocadherin alpha 9
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGPEP1 pyroglutamyl-peptidase I
PLCD1 phospholipase C, delta 1
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2
PVRL3 poliovirus receptor-related 3
PYCRL pyrroline-5-carboxylate reductase-like
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB4B RAB4B, member RAS oncogene family
ROM1 retinal outer segment membrane protein 1
SH3GLB2 SH3-domain GRB2-like endophilin B2
SIGLEC15 sialic acid binding Ig-like lectin 15
SIX1 SIX homeobox 1
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SRD5A3 steroid 5 alpha-reductase 3
STAG3 stromal antigen 3
THOP1 thimet oligopeptidase 1
TMEM115 transmembrane protein 115
TRABD TraB domain containing
TRAIP TRAF interacting protein
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN1 tetraspanin 1
TUBA3D tubulin, alpha 3d
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
ULBP2 UL16 binding protein 2
WFDC2 WAP four-disulfide core domain 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF16 zinc finger protein 16
ZNF639 zinc finger protein 639
ZNF668 zinc finger protein 668
ZNF696 zinc finger protein 696
ZNF862 zinc finger protein 862