benzathine benzylpenicillin-4022 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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193 genes differentially expressed following the benzathine benzylpenicillin-4022 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
AFF1 AF4/FMR2 family, member 1
AGXT alanine-glyoxylate aminotransferase
APOM apolipoprotein M
AREG amphiregulin
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARSE arylsulfatase E (chondrodysplasia punctata 1)
ARTN artemin
AURKA aurora kinase A
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BEND5 BEN domain containing 5
BLZF1 basic leucine zipper nuclear factor 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C8A complement component 8, alpha polypeptide
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CCDC186 coiled-coil domain containing 186
CDC42 cell division cycle 42
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CLCA2 chloride channel accessory 2
CLTA clathrin, light chain A
COL10A1 collagen, type X, alpha 1
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CXCR4 chemokine (C-X-C motif) receptor 4
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DLX5 distal-less homeobox 5
EDRF1 erythroid differentiation regulatory factor 1
EGR1 early growth response 1
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
GYPB glycophorin B (MNS blood group)
HEG1 heart development protein with EGF-like domains 1
HIPK3 homeodomain interacting protein kinase 3
HOXB2 homeobox B2
HP haptoglobin
HPX hemopexin
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
IPO8 importin 8
ITFG2 integrin alpha FG-GAP repeat containing 2
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KLF3 Kruppel-like factor 3 (basic)
KLHL22 kelch-like family member 22
KRTAP9-9 keratin associated protein 9-9
LAG3 lymphocyte-activation gene 3
LDLR low density lipoprotein receptor
MAK male germ cell-associated kinase
MEP1B meprin A, beta
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MILR1 mast cell immunoglobulin-like receptor 1
MUC2 mucin 2, oligomeric mucus/gel-forming
MYBPC3 myosin binding protein C, cardiac
NEU3 sialidase 3 (membrane sialidase)
NNMT nicotinamide N-methyltransferase
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PALM paralemmin
PBX2 pre-B-cell leukemia homeobox 2
PHEX phosphate regulating endopeptidase homolog, X-linked
PHTF2 putative homeodomain transcription factor 2
PKN2 protein kinase N2
PLD1 phospholipase D1, phosphatidylcholine-specific
PRDM14 PR domain containing 14
PRKCI protein kinase C, iota
PRSS22 protease, serine, 22
PSD4 pleckstrin and Sec7 domain containing 4
PTAFR platelet-activating factor receptor
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PTPRR protein tyrosine phosphatase, receptor type, R
RARG retinoic acid receptor, gamma
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RFXAP regulatory factor X-associated protein
RHOBTB3 Rho-related BTB domain containing 3
RIMS3 regulating synaptic membrane exocytosis 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RS1 retinoschisin 1
RTEL1 regulator of telomere elongation helicase 1
S1PR1 sphingosine-1-phosphate receptor 1
SAA3P serum amyloid A3 pseudogene
SCAMP1 secretory carrier membrane protein 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SOS2 son of sevenless homolog 2 (Drosophila)
SPIDR scaffolding protein involved in DNA repair
STK24 serine/threonine kinase 24
STK3 serine/threonine kinase 3
SULF1 sulfatase 1
SYT2 synaptotagmin II
THRB thyroid hormone receptor, beta
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TTC30A tetratricopeptide repeat domain 30A
TTN titin
TUBA3C tubulin, alpha 3c
XYLB xylulokinase homolog (H. influenzae)
YTHDC2 YTH domain containing 2
ZCCHC11 zinc finger, CCHC domain containing 11

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ADGRF1 adhesion G protein-coupled receptor F1
AGMAT agmatine ureohydrolase (agmatinase)
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGAP22 Rho GTPase activating protein 22
ARMCX4 armadillo repeat containing, X-linked 4
ASTN1 astrotactin 1
BST1 bone marrow stromal cell antigen 1
BTF3P11 basic transcription factor 3 pseudogene 11
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
DLK2 delta-like 2 homolog (Drosophila)
DNAH7 dynein, axonemal, heavy chain 7
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EN1 engrailed homeobox 1
ENO3 enolase 3 (beta, muscle)
EPN1 epsin 1
FA2H fatty acid 2-hydroxylase
FBRS fibrosin
FBXL7 F-box and leucine-rich repeat protein 7
FBXO2 F-box protein 2
FGF21 fibroblast growth factor 21
FGF3 fibroblast growth factor 3
FKBP10 FK506 binding protein 10, 65 kDa
FOXN2 forkhead box N2
GJA9 gap junction protein, alpha 9, 59kDa
GLS2 glutaminase 2 (liver, mitochondrial)
GRB7 growth factor receptor-bound protein 7
GREB1L growth regulation by estrogen in breast cancer-like
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
IGLL1 immunoglobulin lambda-like polypeptide 1
IL17RB interleukin 17 receptor B
KCTD17 potassium channel tetramerization domain containing 17
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLHL28 kelch-like family member 28
LGALS4 lectin, galactoside-binding, soluble, 4
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
LOC100127972 uncharacterized LOC100127972
LRRC15 leucine rich repeat containing 15
LRRC61 leucine rich repeat containing 61
LY6D lymphocyte antigen 6 complex, locus D
LYPD3 LY6/PLAUR domain containing 3
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MTERF4 mitochondrial transcription termination factor 4
MTSS1L metastasis suppressor 1-like
MUTYH mutY homolog
MX1 MX dynamin-like GTPase 1
MYH15 myosin, heavy chain 15
MYO1E myosin IE
ONECUT2 one cut homeobox 2
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PAQR5 progestin and adipoQ receptor family member V
PARD6A par-6 family cell polarity regulator alpha
PARP8 poly (ADP-ribose) polymerase family, member 8
PCDHB3 protocadherin beta 3
PCOLCE procollagen C-endopeptidase enhancer
PICK1 protein interacting with PRKCA 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIP prolactin-induced protein
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLXNA3 plexin A3
POMT2 protein-O-mannosyltransferase 2
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRR15L proline rich 15-like
RAB36 RAB36, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SAYSD1 SAYSVFN motif domain containing 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERGEF secretion regulating guanine nucleotide exchange factor
SETD8 SET domain containing (lysine methyltransferase) 8
SH3D21 SH3 domain containing 21
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLAMF7 SLAM family member 7
SLC22A14 solute carrier family 22, member 14
SMR3A submaxillary gland androgen regulated protein 3A
SPATA1 spermatogenesis associated 1
STAB2 stabilin 2
STK16 serine/threonine kinase 16
SYT17 synaptotagmin XVII
TMEM132A transmembrane protein 132A
TMEM40 transmembrane protein 40
TRIM25 tripartite motif containing 25
TTLL1 tubulin tyrosine ligase-like family member 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZNF141 zinc finger protein 141
ZNF268 zinc finger protein 268
ZNF276 zinc finger protein 276
ZNF747 zinc finger protein 747
ZXDB zinc finger, X-linked, duplicated B