benzamil-4760 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the benzamil-4760 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM29 ADAM metallopeptidase domain 29
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMPD3 adenosine monophosphate deaminase 3
ARHGAP24 Rho GTPase activating protein 24
ASIC1 acid sensing (proton gated) ion channel 1
ATF3 activating transcription factor 3
BDKRB2 bradykinin receptor B2
C19ORF66 chromosome 19 open reading frame 66
C7ORF69 chromosome 7 open reading frame 69
CCNJL cyclin J-like
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL6A1 collagen, type VI, alpha 1
CRTC1 CREB regulated transcription coactivator 1
CTRL chymotrypsin-like
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DMPK dystrophia myotonica-protein kinase
DUSP4 dual specificity phosphatase 4
EFR3B EFR3 homolog B (S. cerevisiae)
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ELOVL2 ELOVL fatty acid elongase 2
EPAS1 endothelial PAS domain protein 1
ERAP1 endoplasmic reticulum aminopeptidase 1
FAM13A family with sequence similarity 13, member A
FLJ42627 uncharacterized LOC645644
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GJA8 gap junction protein, alpha 8, 50kDa
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPR135 G protein-coupled receptor 135
GPR3 G protein-coupled receptor 3
GRB10 growth factor receptor-bound protein 10
GREB1L growth regulation by estrogen in breast cancer-like
GRM7 glutamate receptor, metabotropic 7
HFE hemochromatosis
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
ICA1 islet cell autoantigen 1, 69kDa
IDS iduronate 2-sulfatase
IFT27 intraflagellar transport 27
INHBE inhibin, beta E
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAMP1 lysosomal-associated membrane protein 1
LIMK2 LIM domain kinase 2
LOC157562 uncharacterized LOC157562
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK7 mitogen-activated protein kinase 7
MIR622 microRNA 622
MOB3B MOB kinase activator 3B
NCAPH2 non-SMC condensin II complex, subunit H2
NPAS3 neuronal PAS domain protein 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
ONECUT2 one cut homeobox 2
OR7A17 olfactory receptor, family 7, subfamily A, member 17
OVGP1 oviductal glycoprotein 1, 120kDa
PARD3 par-3 family cell polarity regulator
PARP3 poly (ADP-ribose) polymerase family, member 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKNOX2 PBX/knotted 1 homeobox 2
PLA2G2E phospholipase A2, group IIE
PLEKHS1 pleckstrin homology domain containing, family S member 1
PLXNC1 plexin C1
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP4R4 protein phosphatase 4, regulatory subunit 4
PTCRA pre T-cell antigen receptor alpha
RAB6A RAB6A, member RAS oncogene family
RASAL2 RAS protein activator like 2
RGS10 regulator of G-protein signaling 10
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
S100A3 S100 calcium binding protein A3
SCAPER S-phase cyclin A-associated protein in the ER
SCN1B sodium channel, voltage gated, type I beta subunit
SETD1B SET domain containing 1B
SH3D21 SH3 domain containing 21
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMIM14 small integral membrane protein 14
SYP synaptophysin
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX5 T-box 5
TFEB transcription factor EB
THOC5 THO complex 5
TMPRSS4 transmembrane protease, serine 4
TRIM2 tripartite motif containing 2
TROVE2 TROVE domain family, member 2
TSPAN9 tetraspanin 9
UBR2 ubiquitin protein ligase E3 component n-recognin 2
WNT6 wingless-type MMTV integration site family, member 6
WSB1 WD repeat and SOCS box containing 1
ZBED4 zinc finger, BED-type containing 4
ZNF606 zinc finger protein 606
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ARMCX2 armadillo repeat containing, X-linked 2
C1ORF21 chromosome 1 open reading frame 21
C2ORF27A chromosome 2 open reading frame 27A
C2ORF54 chromosome 2 open reading frame 54
CA4 carbonic anhydrase IV
CCRL2 chemokine (C-C motif) receptor-like 2
CENPO centromere protein O
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLSPN claspin
CNGB3 cyclic nucleotide gated channel beta 3
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DOC2A double C2-like domains, alpha
DUSP2 dual specificity phosphatase 2
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FAM46C family with sequence similarity 46, member C
FSTL3 follistatin-like 3 (secreted glycoprotein)
GADD45G growth arrest and DNA-damage-inducible, gamma
GAMT guanidinoacetate N-methyltransferase
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPR143 G protein-coupled receptor 143
GPR27 G protein-coupled receptor 27
GRAMD1C GRAM domain containing 1C
GRTP1 growth hormone regulated TBC protein 1
HAMP hepcidin antimicrobial peptide
HIST1H2AI histone cluster 1, H2ai
HOXC8 homeobox C8
HPN hepsin
JMJD4 jumonji domain containing 4
KCTD17 potassium channel tetramerization domain containing 17
KIAA0125 KIAA0125
KITLG KIT ligand
KLHL25 kelch-like family member 25
KLK5 kallikrein-related peptidase 5
LHX2 LIM homeobox 2
LHX6 LIM homeobox 6
LIG4 ligase IV, DNA, ATP-dependent
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MED9 mediator complex subunit 9
MUM1 melanoma associated antigen (mutated) 1
MYLK myosin light chain kinase
NNAT neuronatin
NOL12 nucleolar protein 12
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPIPB15 nuclear pore complex interacting protein family, member B15
NPTX1 neuronal pentraxin I
ONECUT1 one cut homeobox 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PCDHB8 protocadherin beta 8
PCDHGB5 protocadherin gamma subfamily B, 5
PDE12 phosphodiesterase 12
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGR progesterone receptor
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLD2 phospholipase D2
PMCH pro-melanin-concentrating hormone
POMT2 protein-O-mannosyltransferase 2
PTPN14 protein tyrosine phosphatase, non-receptor type 14
QPCTL glutaminyl-peptide cyclotransferase-like
RAI2 retinoic acid induced 2
RCAN3 RCAN family member 3
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REM1 RAS (RAD and GEM)-like GTP-binding 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RLN2 relaxin 2
RPA4 replication protein A4, 30kDa
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RRAGB Ras-related GTP binding B
S100A2 S100 calcium binding protein A2
SAMD9 sterile alpha motif domain containing 9
SAYSD1 SAYSVFN motif domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SELL selectin L
SERGEF secretion regulating guanine nucleotide exchange factor
SGK1 serum/glucocorticoid regulated kinase 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SPINK1 serine peptidase inhibitor, Kazal type 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYCP2 synaptonemal complex protein 2
TBX3 T-box 3
TMEM38B transmembrane protein 38B
TNRC6B trinucleotide repeat containing 6B
TNS2 tensin 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBTD1 ubiquitin domain containing 1
USB1 U6 snRNA biogenesis 1
VASH2 vasohibin 2
VEZT vezatin, adherens junctions transmembrane protein
ZBTB44 zinc finger and BTB domain containing 44
ZNF10 zinc finger protein 10
ZNF253 zinc finger protein 253
ZNF480 zinc finger protein 480
ZNF506 zinc finger protein 506