benign mesothelioma Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A cell type benign neoplasm that has_material_basis in mesothelium. (Human Disease Ontology, DOID_2645)
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Genes

288 genes co-occuring with the disease benign mesothelioma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MSLN mesothelin 2.61591
CALB2 calbindin 2 2.6097
KRT5 keratin 5, type II 1.96661
PTGER4 prostaglandin E receptor 4 (subtype EP4) 1.89731
WT1 Wilms tumor 1 1.64218
THBD thrombomodulin 1.59028
CD86 CD86 molecule 1.3904
TYMS thymidylate synthetase 1.3494
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 1.3145
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 1.28697
NKX2-1 NK2 homeobox 1 1.24515
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 1.21565
TP53 tumor protein p53 1.19316
PDPN podoplanin 1.18238
CDKN2A cyclin-dependent kinase inhibitor 2A 1.149
SPP1 secreted phosphoprotein 1 1.14348
NF2 neurofibromin 2 (merlin) 1.10889
DHFR dihydrofolate reductase 1.08705
KRT7 keratin 7, type II 1.00203
CD34 CD34 molecule 0.981794
F8 coagulation factor VIII, procoagulant component 0.957868
CLDN4 claudin 4 0.93497
EGFR epidermal growth factor receptor 0.892129
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 0.889668
LRRN4 leucine rich repeat neuronal 4 0.885569
MFGE8 milk fat globule-EGF factor 8 protein 0.869596
RPL18A ribosomal protein L18a 0.842163
MTAP methylthioadenosine phosphorylase 0.815104
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.811001
MUC16 mucin 16, cell surface associated 0.781479
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.75412
HBA2 hemoglobin, alpha 2 0.736243
HBA1 hemoglobin, alpha 1 0.735027
KRT20 keratin 20, type I 0.726929
NAPSA napsin A aspartic peptidase 0.724502
MYO7B myosin VIIB 0.711989
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.689492
ADA adenosine deaminase 0.681096
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.678302
SLC46A1 solute carrier family 46 (folate transporter), member 1 0.662387
UPK3B uroplakin 3B 0.657234
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.648928
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.648138
SNX25 sorting nexin 25 0.643797
SDC1 syndecan 1 0.643404
TARS threonyl-tRNA synthetase 0.634742
DEFB129 defensin, beta 129 0.633563
SLC7A14 solute carrier family 7, member 14 0.633169
IL2 interleukin 2 0.626103
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.621792
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 0.6214
MPZL1 myelin protein zero-like 1 0.620226
SRR serine racemase 0.612401
CD44 CD44 molecule (Indian blood group) 0.606933
BCL2L1 BCL2-like 1 0.60147
MAGEA10 melanoma antigen family A10 0.596012
RNASEH2A ribonuclease H2, subunit A 0.582773
LIMS2 LIM and senescent cell antigen-like domains 2 0.578494
IL4I1 interleukin 4 induced 1 0.577327
ITCH itchy E3 ubiquitin protein ligase 0.572273
PSPH phosphoserine phosphatase 0.566443
CD4 CD4 molecule 0.566054
BIRC5 baculoviral IAP repeat containing 5 0.561004
AK7 adenylate kinase 7 0.556344
FGF6 fibroblast growth factor 6 0.553627
TUSC2 tumor suppressor candidate 2 0.550522
MARS methionyl-tRNA synthetase 0.547032
LIMS3 LIM and senescent cell antigen-like domains 3 0.542767
SDC4 syndecan 4 0.540055
FABP9 fatty acid binding protein 9, testis 0.539667
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.511112
FOLR3 folate receptor 3 (gamma) 0.502292
TRIP6 thyroid hormone receptor interactor 6 0.498467
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.495793
MET MET proto-oncogene, receptor tyrosine kinase 0.494266
TMEM30B transmembrane protein 30B 0.491978
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.488549
CUL4A cullin 4A 0.483224
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.477909
PAX8 paired box 8 0.470332
IGHV3-30 immunoglobulin heavy variable 3-30 0.465038
ENO2 enolase 2 (gamma, neuronal) 0.463527
ERCC1 excision repair cross-complementation group 1 0.457487
SOD2 superoxide dismutase 2, mitochondrial 0.457109
LRRC6 leucine rich repeat containing 6 0.456355
PRPF19 pre-mRNA processing factor 19 0.445805
OTOA otoancorin 0.445052
CSPG4 chondroitin sulfate proteoglycan 4 0.44129
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.440538
AXL AXL receptor tyrosine kinase 0.427765
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.427015
RAB12 RAB12, member RAS oncogene family 0.418394
VEGFA vascular endothelial growth factor A 0.412405
ZDHHC8 zinc finger, DHHC-type containing 8 0.407919
METAP2 methionyl aminopeptidase 2 0.407545
TNNT1 troponin T type 1 (skeletal, slow) 0.405305
DVL1 dishevelled segment polarity protein 1 0.403064
CA9 carbonic anhydrase IX 0.400826
NCAM1 neural cell adhesion molecule 1 0.40008
TM4SF1 transmembrane 4 L six family member 1 0.398216
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.396353
FNTA farnesyltransferase, CAAX box, alpha 0.39598
WIPF2 WAS/WASL interacting protein family, member 2 0.39598
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.391141
SDC2 syndecan 2 0.385565
CDAN1 codanin 1 0.383708
MSLNL mesothelin-like 0.381852
FURIN furin (paired basic amino acid cleaving enzyme) 0.381481
FOSL1 FOS-like antigen 1 0.37555
RBL2 retinoblastoma-like 2 0.373698
AGGF1 angiogenic factor with G patch and FHA domains 1 0.373328
TEAD4 TEA domain family member 4 0.370368
TXN thioredoxin 0.369628
FOXP3 forkhead box P3 0.362978
WDR13 WD repeat domain 13 0.362978
NSL1 NSL1, MIS12 kinetochore complex component 0.361133
RBM8A RNA binding motif protein 8A 0.360764
CLDN15 claudin 15 0.358551
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.357446
EVI5 ecotropic viral integration site 5 0.357077
CAT catalase 0.354499
FGF2 fibroblast growth factor 2 (basic) 0.351555
PRDX3 peroxiredoxin 3 0.348246
SFRP4 secreted frizzled-related protein 4 0.346042
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.345675
RAP1A RAP1A, member of RAS oncogene family 0.344941
CD68 CD68 molecule 0.34384
EIF4A2 eukaryotic translation initiation factor 4A2 0.343473
TOP2A topoisomerase (DNA) II alpha 170kDa 0.341272
TICAM2 toll-like receptor adaptor molecule 2 0.338707
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.337242
CSF1R colony stimulating factor 1 receptor 0.33651
TERT telomerase reverse transcriptase 0.333949
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.333583
TNC tenascin C 0.332852
PTPRC protein tyrosine phosphatase, receptor type, C 0.32993
HIAT1 hippocampus abundant transcript 1 0.326646
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.325916
THRB thyroid hormone receptor, beta 0.325552
KLK11 kallikrein-related peptidase 11 0.324823
KAT7 K(lysine) acetyltransferase 7 0.324458
BAX BCL2-associated X protein 0.323365
MMP2 matrix metallopeptidase 2 0.323002
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.319726
SSX1 synovial sarcoma, X breakpoint 1 0.316456
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 0.315003
MYOG myogenin (myogenic factor 4) 0.311739
ASXL2 additional sex combs like transcriptional regulator 2 0.31029
IFNA1 interferon, alpha 1 0.309928
HAPLN1 hyaluronan and proteoglycan link protein 1 0.307757
THBS2 thrombospondin 2 0.307033
SRL sarcalumenin 0.305948
CHEK1 checkpoint kinase 1 0.305587
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.305226
SYP synaptophysin 0.304864
STRCP1 stereocilin pseudogene 1 0.303059
STRC stereocilin 0.303059
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 0.300533
IGF1R insulin-like growth factor 1 receptor 0.300533
KRT19 keratin 19, type I 0.299092
SFTPC surfactant protein C 0.298011
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.294413
MAPK13 mitogen-activated protein kinase 13 0.292616
AHNAK AHNAK nucleoprotein 0.292257
PDGFA platelet-derived growth factor alpha polypeptide 0.290821
IGF2 insulin-like growth factor 2 0.290103
GAGE1 G antigen 1 0.285086
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.284371
METAP1 methionyl aminopeptidase 1 0.280082
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.279367
HOXB9 homeobox B9 0.279011
SFRP1 secreted frizzled-related protein 1 0.272241
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.270819
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.270108
HTRA1 HtrA serine peptidase 1 0.265494
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.264077
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.263368
EPHB4 EPH receptor B4 0.261599
ALPP alkaline phosphatase, placental 0.260538
BGN biglycan 0.260538
LSM1 LSM1, U6 small nuclear RNA associated 0.260538
ALPPL2 alkaline phosphatase, placental-like 2 0.25877
JUN jun proto-oncogene 0.258064
ALPL alkaline phosphatase, liver/bone/kidney 0.257711
OGG1 8-oxoguanine DNA glycosylase 0.257711
ACTG2 actin, gamma 2, smooth muscle, enteric 0.254536
GSTA3 glutathione S-transferase alpha 3 0.254536
CALD1 caldesmon 1 0.254183
TGFB1 transforming growth factor, beta 1 0.253831
GSTA2 glutathione S-transferase alpha 2 0.253127
GSTA4 glutathione S-transferase alpha 4 0.25207
PIP prolactin-induced protein 0.250663
RRM1 ribonucleotide reductase M1 0.250663
GSTA1 glutathione S-transferase alpha 1 0.246799
EGR4 early growth response 4 0.245396
HCFC1 host cell factor C1 0.245046
FTL ferritin, light polypeptide 0.244696
FTH1 ferritin, heavy polypeptide 1 0.244345
GAGE12I G antigen 12I 0.242245
PDGFB platelet-derived growth factor beta polypeptide 0.239799
ANKRD11 ankyrin repeat domain 11 0.23945
CLMP CXADR-like membrane protein 0.239101
HRAS Harvey rat sarcoma viral oncogene homolog 0.238752
MAGEA1 melanoma antigen family A1 0.235268
CD99 CD99 molecule 0.234573
WIF1 WNT inhibitory factor 1 0.230409
CDK4 cyclin-dependent kinase 4 0.229024
TRPM5 transient receptor potential cation channel, subfamily M, member 5 0.227642
SPARCL1 SPARC-like 1 (hevin) 0.226607
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.223509
COPA coatomer protein complex, subunit alpha 0.223165
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.223165
NCR1 natural cytotoxicity triggering receptor 1 0.222822
PRAMEF6 PRAME family member 6 0.220766
H2AFX H2A histone family, member X 0.220424
TYMP thymidine phosphorylase 0.220081
B3GAT1 beta-1,3-glucuronyltransferase 1 0.21974
ALB albumin 0.21974
FOLR1 folate receptor 1 (adult) 0.219057
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.217352
RB1 retinoblastoma 1 0.214297
PDYN prodynorphin 0.212271
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.210925
GAB1 GRB2-associated binding protein 1 0.210589
RECQL5 RecQ protein-like 5 0.210253
FGF17 fibroblast growth factor 17 0.209583
PER1 period circadian clock 1 0.209248
KRT18 keratin 18, type I 0.207245
WEE1 WEE1 G2 checkpoint kinase 0.200982
IL4R interleukin 4 receptor 0.199681
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.198386
UCKL1 uridine-cytidine kinase 1-like 1 0.195183
CSH2 chorionic somatomammotropin hormone 2 0.1936
PTEN phosphatase and tensin homolog 0.192031
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.190786
IL6 interleukin 6 0.189859
UCK1 uridine-cytidine kinase 1 0.189244
IRF6 interferon regulatory factor 6 0.189244
CARS cysteinyl-tRNA synthetase 0.188632
KITLG KIT ligand 0.187719
CD40 CD40 molecule, TNF receptor superfamily member 5 0.187415
AKR1C4 aldo-keto reductase family 1, member C4 0.18591
ASS1 argininosuccinate synthase 1 0.185612
CCNB1 cyclin B1 0.184128
EPCAM epithelial cell adhesion molecule 0.183541
CYTL1 cytokine-like 1 0.183248
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.182375
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.182086
AFP alpha-fetoprotein 0.181798
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.181798
MCM2 minichromosome maintenance complex component 2 0.180937
ERBB2 erb-b2 receptor tyrosine kinase 2 0.180652
CAV1 caveolin 1, caveolae protein, 22kDa 0.180652
GLE1 GLE1 RNA export mediator 0.180084
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.178682
NME1-NME2 NME1-NME2 readthrough 0.177851
BST1 bone marrow stromal cell antigen 1 0.177301
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 0.176215
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.175411
FLT1 fms-related tyrosine kinase 1 0.173314
GCLC glutamate-cysteine ligase, catalytic subunit 0.173057
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 0.171535
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.170544
NID2 nidogen 2 (osteonidogen) 0.168617
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 0.168381
GAS6 growth arrest-specific 6 0.168381
IFNB1 interferon, beta 1, fibroblast 0.167682
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.166768
PRDX1 peroxiredoxin 1 0.166544
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.166095
TNF tumor necrosis factor 0.164359
DVL3 dishevelled segment polarity protein 3 0.163729
EIF4E eukaryotic translation initiation factor 4E 0.162505
IGF1 insulin-like growth factor 1 (somatomedin C) 0.161331
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.160761
SFTPB surfactant protein B 0.159658
CTSC cathepsin C 0.159302
FOS FBJ murine osteosarcoma viral oncogene homolog 0.159124
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.158266
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.158097
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.158097
SCGB2A1 secretoglobin, family 2A, member 1 0.157929
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.157765
CES2 carboxylesterase 2 0.157602
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.14061
KRT14 keratin 14, type I 0.132245
KRT8 keratin 8, type II 0.131182
INS insulin 0.12959