bendroflumethiazide-4315 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the bendroflumethiazide-4315 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
AKR1C1 aldo-keto reductase family 1, member C1
APAF1 apoptotic peptidase activating factor 1
ARRB1 arrestin, beta 1
BCL2L1 BCL2-like 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD1D CD1d molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CELF2 CUGBP, Elav-like family member 2
CHAT choline O-acetyltransferase
COL6A1 collagen, type VI, alpha 1
COPE coatomer protein complex, subunit epsilon
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CYBB cytochrome b-245, beta polypeptide
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DAPK1 death-associated protein kinase 1
DENND2D DENN/MADD domain containing 2D
DGCR8 DGCR8 microprocessor complex subunit
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DSCAM Down syndrome cell adhesion molecule
DTNA dystrobrevin, alpha
EDRF1 erythroid differentiation regulatory factor 1
ETV7 ets variant 7
FAM149B1 family with sequence similarity 149, member B1
FANCF Fanconi anemia, complementation group F
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FUBP1 far upstream element (FUSE) binding protein 1
GBP2 guanylate binding protein 2, interferon-inducible
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
HFE hemochromatosis
HIST1H3E histone cluster 1, H3e
HRK harakiri, BCL2 interacting protein
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSF1 heat shock transcription factor 1
HSPG2 heparan sulfate proteoglycan 2
IDS iduronate 2-sulfatase
IFFO1 intermediate filament family orphan 1
IGL immunoglobulin lambda locus
IL5RA interleukin 5 receptor, alpha
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KMT2A lysine (K)-specific methyltransferase 2A
LAT2 linker for activation of T cells family, member 2
LY75 lymphocyte antigen 75
MAX MYC associated factor X
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MED25 mediator complex subunit 25
MLXIP MLX interacting protein
MPZ myelin protein zero
MVB12B multivesicular body subunit 12B
N4BP2L1 NEDD4 binding protein 2-like 1
NEURL1 neuralized E3 ubiquitin protein ligase 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOX1 NADPH oxidase 1
NPTXR neuronal pentraxin receptor
NUMA1 nuclear mitotic apparatus protein 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE4A phosphodiesterase 4A, cAMP-specific
PICALM phosphatidylinositol binding clathrin assembly protein
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIP prolactin-induced protein
POU2AF1 POU class 2 associating factor 1
POU5F1B POU class 5 homeobox 1B
PRAMEF10 PRAME family member 10
PRR5 proline rich 5 (renal)
PTCH2 patched 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
QPRT quinolinate phosphoribosyltransferase
RARB retinoic acid receptor, beta
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RGS5 regulator of G-protein signaling 5
RPL18 ribosomal protein L18
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SH2B1 SH2B adaptor protein 1
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SPPL2B signal peptide peptidase like 2B
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAB1 stabilin 1
STC1 stanniocalcin 1
TBX2 T-box 2
TMEM206 transmembrane protein 206
TMSB15A thymosin beta 15a
TNPO2 transportin 2
TONSL tonsoku-like, DNA repair protein
TRIL TLR4 interactor with leucine-rich repeats
TTC22 tetratricopeptide repeat domain 22
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
USH2A Usher syndrome 2A (autosomal recessive, mild)
VPS9D1 VPS9 domain containing 1
WNT3 wingless-type MMTV integration site family, member 3
ZIM2 zinc finger, imprinted 2

decreased expression

Symbol Name
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
ARSB arylsulfatase B
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
C4ORF29 chromosome 4 open reading frame 29
C8ORF44 chromosome 8 open reading frame 44
CD101 CD101 molecule
CD53 CD53 molecule
CD70 CD70 molecule
CIDEB cell death-inducing DFFA-like effector b
CLEC2B C-type lectin domain family 2, member B
CRMP1 collapsin response mediator protein 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
ELMO3 engulfment and cell motility 3
ELP6 elongator acetyltransferase complex subunit 6
FAM50B family with sequence similarity 50, member B
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBRS fibrosin
FGL1 fibrinogen-like 1
FZD10 frizzled class receptor 10
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GCHFR GTP cyclohydrolase I feedback regulator
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GSTM5 glutathione S-transferase mu 5
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1E histone cluster 1, H1e
HIST1H2AJ histone cluster 1, H2aj
HLX H2.0-like homeobox
HMGB3P1 high mobility group box 3 pseudogene 1
HOXB2 homeobox B2
HOXC5 homeobox C5
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL17RB interleukin 17 receptor B
IL24 interleukin 24
IL4R interleukin 4 receptor
INF2 inverted formin, FH2 and WH2 domain containing
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
LRRC61 leucine rich repeat containing 61
LYPD3 LY6/PLAUR domain containing 3
LYRM9 LYR motif containing 9
MATN3 matrilin 3
MDFI MyoD family inhibitor
NAT6 N-acetyltransferase 6 (GCN5-related)
NKX3-2 NK3 homeobox 2
NUBP1 nucleotide binding protein 1
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
PADI1 peptidyl arginine deiminase, type I
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PARP6 poly (ADP-ribose) polymerase family, member 6
PDE5A phosphodiesterase 5A, cGMP-specific
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PMCH pro-melanin-concentrating hormone
POLL polymerase (DNA directed), lambda
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPT2 palmitoyl-protein thioesterase 2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RECQL4 RecQ protein-like 4
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF126P1 ring finger protein 126 pseudogene 1
RPAIN RPA interacting protein
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
S1PR1 sphingosine-1-phosphate receptor 1
SETD6 SET domain containing 6
SLC12A8 solute carrier family 12, member 8
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC38A10 solute carrier family 38, member 10
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
STAG3 stromal antigen 3
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STRA6 stimulated by retinoic acid 6
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAOK1 TAO kinase 1
TBXAS1 thromboxane A synthase 1 (platelet)
TEP1 telomerase-associated protein 1
TET3 tet methylcytosine dioxygenase 3
THRAP3 thyroid hormone receptor associated protein 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM19 transmembrane protein 19
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VEZT vezatin, adherens junctions transmembrane protein
VN1R1 vomeronasal 1 receptor 1
WDR76 WD repeat domain 76
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF219 zinc finger protein 219
ZNF222 zinc finger protein 222
ZNF652 zinc finger protein 652
ZNF668 zinc finger protein 668
ZNF675 zinc finger protein 675