azapropazone-6522 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the azapropazone-6522 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
ALDOB aldolase B, fructose-bisphosphate
ARHGAP26 Rho GTPase activating protein 26
ARRB2 arrestin, beta 2
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BDKRB1 bradykinin receptor B1
C19ORF40 chromosome 19 open reading frame 40
C7ORF69 chromosome 7 open reading frame 69
CACTIN cactin, spliceosome C complex subunit
CALB2 calbindin 2
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFAP45 cilia and flagella associated protein 45
CHRND cholinergic receptor, nicotinic, delta (muscle)
CLCN4 chloride channel, voltage-sensitive 4
CRTC1 CREB regulated transcription coactivator 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYLD cylindromatosis (turban tumor syndrome)
DENND3 DENN/MADD domain containing 3
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DTNA dystrobrevin, alpha
EDNRA endothelin receptor type A
EFCAB6 EF-hand calcium binding domain 6
EPHB2 EPH receptor B2
ERAP1 endoplasmic reticulum aminopeptidase 1
FAM134B family with sequence similarity 134, member B
FRS3 fibroblast growth factor receptor substrate 3
FSTL3 follistatin-like 3 (secreted glycoprotein)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GFER growth factor, augmenter of liver regeneration
GREB1 growth regulation by estrogen in breast cancer 1
GSTA1 glutathione S-transferase alpha 1
HDAC11 histone deacetylase 11
HLA-DOA major histocompatibility complex, class II, DO alpha
HYAL3 hyaluronoglucosaminidase 3
ICOSLG inducible T-cell co-stimulator ligand
IL1RN interleukin 1 receptor antagonist
IQCA1 IQ motif containing with AAA domain 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LIN7A lin-7 homolog A (C. elegans)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K7 mitogen-activated protein kinase kinase 7
MAX MYC associated factor X
MED16 mediator complex subunit 16
MFAP3 microfibrillar-associated protein 3
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIER2 mesoderm induction early response 1, family member 2
MIIP migration and invasion inhibitory protein
MIR622 microRNA 622
MST1R macrophage stimulating 1 receptor
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEFH neurofilament, heavy polypeptide
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PAOX polyamine oxidase (exo-N4-amino)
PCDH1 protocadherin 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIAS4 protein inhibitor of activated STAT, 4
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLCD1 phospholipase C, delta 1
PPP5C protein phosphatase 5, catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PYY peptide YY
RAD54L2 RAD54-like 2 (S. cerevisiae)
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPLP2 ribosomal protein, large, P2
SH2D2A SH2 domain containing 2A
SIRPA signal-regulatory protein alpha
SLC16A4 solute carrier family 16, member 4
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMG6 SMG6 nonsense mediated mRNA decay factor
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBXA2R thromboxane A2 receptor
TCP10L t-complex 10-like
TENM4 teneurin transmembrane protein 4
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TLN1 talin 1
TOR4A torsin family 4, member A
TRIB2 tribbles pseudokinase 2
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
USB1 U6 snRNA biogenesis 1
USP2 ubiquitin specific peptidase 2
WIPI2 WD repeat domain, phosphoinositide interacting 2
ZMYM6 zinc finger, MYM-type 6
ZNF44 zinc finger protein 44
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32A-IT1 ANP32A intronic transcript 1
ARHGAP5 Rho GTPase activating protein 5
ASB7 ankyrin repeat and SOCS box containing 7
ATAD2B ATPase family, AAA domain containing 2B
BAGE B melanoma antigen
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C11ORF30 chromosome 11 open reading frame 30
C8ORF60 chromosome 8 open reading frame 60
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CD82 CD82 molecule
CDON cell adhesion associated, oncogene regulated
CEP97 centrosomal protein 97kDa
CFAP44 cilia and flagella associated protein 44
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLDN15 claudin 15
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DCTN4 dynactin 4 (p62)
DYSF dysferlin
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EAF2 ELL associated factor 2
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERCC6 excision repair cross-complementation group 6
ERN2 endoplasmic reticulum to nucleus signaling 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAREM GRB2 associated, regulator of MAPK1
GMCL1 germ cell-less, spermatogenesis associated 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUSBP3 glucuronidase, beta pseudogene 3
HAMP hepcidin antimicrobial peptide
HCFC2 host cell factor C2
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
IL17RA interleukin 17 receptor A
IL4R interleukin 4 receptor
INSIG2 insulin induced gene 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KLF3 Kruppel-like factor 3 (basic)
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL25 kelch-like family member 25
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRP2 low density lipoprotein receptor-related protein 2
LRRC8D leucine rich repeat containing 8 family, member D
LTBP2 latent transforming growth factor beta binding protein 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGEF1 melanoma antigen family F1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MGC12488
MMP2 matrix metallopeptidase 2
MORC3 MORC family CW-type zinc finger 3
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPS18C mitochondrial ribosomal protein S18C
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFE2L3 nuclear factor, erythroid 2-like 3
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
ONECUT2 one cut homeobox 2
PCDH12 protocadherin 12
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDGFD platelet derived growth factor D
PITX2 paired-like homeodomain 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PTGES2 prostaglandin E synthase 2
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RPGRIP1L RPGRIP1-like
SCGB2A2 secretoglobin, family 2A, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SCYL2 SCY1-like 2 (S. cerevisiae)
SECTM1 secreted and transmembrane 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SGPP1 sphingosine-1-phosphate phosphatase 1
SH2B3 SH2B adaptor protein 3
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SRD5A3 steroid 5 alpha-reductase 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYBU syntabulin (syntaxin-interacting)
SYNC syncoilin, intermediate filament protein
TARP TCR gamma alternate reading frame protein
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
THBS3 thrombospondin 3
THUMPD2 THUMP domain containing 2
TMEM120B transmembrane protein 120B
TMEM254 transmembrane protein 254
TTBK2 tau tubulin kinase 2
TTC4 tetratricopeptide repeat domain 4
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZBTB22 zinc finger and BTB domain containing 22
ZNF329 zinc finger protein 329
ZNF516 zinc finger protein 516
ZNF74 zinc finger protein 74
ZNF778 zinc finger protein 778
ZSCAN26 zinc finger and SCAN domain containing 26