autoimmune thrombocytopenic purpura Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A primary thrombocytopenia that involves relatively few platelets in blood as a result of autoantibodies. (Human Disease Ontology, DOID_8924)
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Genes

131 genes co-occuring with the disease autoimmune thrombocytopenic purpura in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
THPO thrombopoietin 2.08174
MPL MPL proto-oncogene, thrombopoietin receptor 1.69224
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 1.67638
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 1.47198
PSMG3 proteasome (prosome, macropain) assembly chaperone 3 1.34374
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 1.21652
POU2F3 POU class 2 homeobox 3 1.08495
CD4 CD4 molecule 1.06858
CD79A CD79a molecule, immunoglobulin-associated alpha 1.04251
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.97086
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 0.964148
FOXG1 forkhead box G1 0.947852
NAAA N-acylethanolamine acid amidase 0.928759
F8 coagulation factor VIII, procoagulant component 0.917199
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.91061
VWF von Willebrand factor 0.893359
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.870415
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 0.864684
HPSE2 heparanase 2 (inactive) 0.836837
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.821257
RHOD ras homolog family member D 0.818796
CD40LG CD40 ligand 0.817565
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) 0.811001
GATA3 GATA binding protein 3 0.770435
IL18BP interleukin 18 binding protein 0.767576
MYH9 myosin, heavy chain 9, non-muscle 0.765535
CD19 CD19 molecule 0.727738
TBX21 T-box 21 0.72612
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.724502
EPSTI1 epithelial stromal interaction 1 (breast) 0.711989
RHD Rh blood group, D antigen 0.708364
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.703938
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.703536
F3 coagulation factor III (thromboplastin, tissue factor) 0.689893
IFNA2 interferon, alpha 2 0.683493
IFRD1 interferon-related developmental regulator 1 0.675112
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.666755
GP1BB glycoprotein Ib (platelet), beta polypeptide 0.664769
PLAC8 placenta-specific 8 0.650113
POMP proteasome maturation protein 0.639463
TRIM37 tripartite motif containing 37 0.637889
INTS8 integrator complex subunit 8 0.636708
IGHV4-39 immunoglobulin heavy variable 4-39 0.610057
IL11 interleukin 11 0.6003
PIGM phosphatidylinositol glycan anchor biosynthesis, class M 0.590169
SIGLEC7 sialic acid binding Ig-like lectin 7 0.583552
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.583163
KEL Kell blood group, metallo-endopeptidase 0.574217
SYK spleen tyrosine kinase 0.569163
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.566054
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.555568
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.554015
POMC proopiomelanocortin 0.552851
CD80 CD80 molecule 0.549747
GP1BA glycoprotein Ib (platelet), alpha polypeptide 0.547807
CD40 CD40 molecule, TNF receptor superfamily member 5 0.518034
FASLG Fas ligand (TNF superfamily, member 6) 0.516879
HP haptoglobin 0.51188
NCAM1 neural cell adhesion molecule 1 0.509192
HPR haptoglobin-related protein 0.505739
IFNA1 interferon, alpha 1 0.495793
PROS1 protein S (alpha) 0.489691
GRB2 growth factor receptor-bound protein 2 0.488169
FOXP3 forkhead box P3 0.486266
DEFA3 defensin, alpha 3, neutrophil-specific 0.468441
GIF gastric intrinsic factor (vitamin B synthesis) 0.462016
CT45A1 cancer/testis antigen family 45, member A1 0.435275
IL2 interleukin 2 0.430393
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.428891
ALB albumin 0.427765
CD96 CD96 molecule 0.425514
PF4 platelet factor 4 0.42139
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.419892
TGFB1 transforming growth factor, beta 1 0.417644
HLA-A major histocompatibility complex, class I, A 0.413153
IL18 interleukin 18 0.393374
GP9 glycoprotein IX (platelet) 0.389281
CD52 CD52 molecule 0.388166
CTPS1 CTP synthase 1 0.379997
DNASE1L3 deoxyribonuclease I-like 3 0.375179
F2 coagulation factor II (thrombin) 0.369997
IFI27 interferon, alpha-inducible protein 27 0.364824
IL6 interleukin 6 0.364824
HLA-C major histocompatibility complex, class I, C 0.363347
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 0.363347
IGLV9-49 immunoglobulin lambda variable 9-49 0.355604
SBF2 SET binding factor 2 0.350084
RHCE Rh blood group, CcEe antigens 0.345675
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.341272
GATA2 GATA binding protein 2 0.340539
RAN RAN, member RAS oncogene family 0.336144
IL2RA interleukin 2 receptor, alpha 0.334315
CD36 CD36 molecule (thrombospondin receptor) 0.33066
CCNC cyclin C 0.328105
CD86 CD86 molecule 0.322273
MBD1 methyl-CpG binding domain protein 1 0.31464
IL3 interleukin 3 0.308842
IGKV3-20 immunoglobulin kappa variable 3-20 0.303781
IFNG interferon, gamma 0.300173
GP6 glycoprotein VI (platelet) 0.297651
KAT8 K(lysine) acetyltransferase 8 0.295851
BCAM basal cell adhesion molecule (Lutheran blood group) 0.294772
SLCO2B1 solute carrier organic anion transporter family, member 2B1 0.294053
CD34 CD34 molecule 0.288668
HOXB4 homeobox B4 0.287235
THBD thrombomodulin 0.281868
IL2RB interleukin 2 receptor, beta 0.280082
CD5 CD5 molecule 0.268332
INSC inscuteable homolog (Drosophila) 0.258417
UST uronyl-2-sulfotransferase 0.253127
CD72 CD72 molecule 0.253127
SH3BP2 SH3-domain binding protein 2 0.239799
ALPPL2 alkaline phosphatase, placental-like 2 0.234225
ALPP alkaline phosphatase, placental 0.233878
ALPL alkaline phosphatase, liver/bone/kidney 0.233183
IL1RN interleukin 1 receptor antagonist 0.231448
IL4 interleukin 4 0.213283
CYS1 cystin 1 0.208914
RNF112 ring finger protein 112 0.205916
LCK LCK proto-oncogene, Src family tyrosine kinase 0.204263
BCO1 beta-carotene oxygenase 1 0.201308
APOH apolipoprotein H (beta-2-glycoprotein I) 0.19742
UBIAD1 UbiA prenyltransferase domain containing 1 0.189859
AGO2 argonaute RISC catalytic component 2 0.18472
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.184424
MT3 metallothionein 3 0.180084
FKBP5 FK506 binding protein 5 0.172799
TNF tumor necrosis factor 0.172291
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.16933
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.159838
ISG20 interferon stimulated exonuclease gene 20kDa 0.158434