autoimmune disease of skin and connective tissue Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the skin and connective tissue. (Human Disease Ontology, DOID_0060039)
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Genes

219 genes co-occuring with the disease autoimmune disease of skin and connective tissue in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
COL17A1 collagen, type XVII, alpha 1 3.56616
CD79A CD79a molecule, immunoglobulin-associated alpha 2.57109
COL7A1 collagen, type VII, alpha 1 2.2967
DSG3 desmoglein 3 2.16707
DST dystonin 2.0554
DSG1 desmoglein 1 1.98668
DSP desmoplakin 1.94877
PPL periplakin 1.86644
EVPL envoplakin 1.45089
ITGA6 integrin, alpha 6 1.4465
MACF1 microtubule-actin crosslinking factor 1 1.23863
FN1 fibronectin 1 1.19445
SRRM1 serine/arginine repetitive matrix 1 1.1194
A2ML1 alpha-2-macroglobulin-like 1 1.08873
ITGB4 integrin, beta 4 1.0484
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.01934
TGM2 transglutaminase 2 1.00288
TGM3 transglutaminase 3 0.936629
LAMA3 laminin, alpha 3 0.93207
LAMC2 laminin, gamma 2 0.928346
TMIGD2 transmembrane and immunoglobulin domain containing 2 0.914727
CGREF1 cell growth regulator with EF-hand domain 1 0.914727
LAMB2 laminin, beta 2 (laminin S) 0.899924
TPSB2 tryptase beta 2 (gene/pseudogene) 0.895
KRT3 keratin 3, type II 0.885979
NID1 nidogen 1 0.866321
IVL involucrin 0.840115
FLG filaggrin 0.820437
LAMB3 laminin, beta 3 0.78066
DSC1 desmocollin 1 0.763902
HLA-C major histocompatibility complex, class I, C 0.75412
PLG plasminogen 0.75005
C3 complement component 3 0.738271
IL5 interleukin 5 0.735838
CD4 CD4 molecule 0.733001
FRMD4B FERM domain containing 4B 0.700321
HSPG2 heparan sulfate proteoglycan 2 0.691094
MMP9 matrix metallopeptidase 9 0.662387
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.646165
NCKIPSD NCK interacting protein with SH3 domain 0.624927
CFP complement factor properdin 0.622183
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.621792
HLA-DQB3 major histocompatibility complex, class II, DQ beta 3 0.613574
RNASE3 ribonuclease, RNase A family, 3 0.59952
CCL26 chemokine (C-C motif) ligand 26 0.597571
HOXC8 homeobox C8 0.591337
CD44 CD44 molecule (Indian blood group) 0.590558
KRT13 keratin 13, type I 0.585887
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 0.585497
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.581996
LAMB4 laminin, beta 4 0.567997
TPSAB1 tryptase alpha/beta 1 0.560616
BHLHE23 basic helix-loop-helix family, member e23 0.552851
ELANE elastase, neutrophil expressed 0.538118
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.537731
PITPNB phosphatidylinositol transfer protein, beta 0.533088
PLAU plasminogen activator, urokinase 0.519575
CDSN corneodesmosin 0.51842
LPP LIM domain containing preferred translocation partner in lipoma 0.508424
MED10 mediator complex subunit 10 0.503441
IL1A interleukin 1, alpha 0.502292
TGM6 transglutaminase 6 0.496939
DSC3 desmocollin 3 0.496939
KRT14 keratin 14, type I 0.488549
IL2RA interleukin 2 receptor, alpha 0.488549
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.476772
DHODH dihydroorotate dehydrogenase (quinone) 0.467684
C5AR1 complement component 5a receptor 1 0.449947
CD200 CD200 molecule 0.449194
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.438658
MMP10 matrix metallopeptidase 10 0.43753
RAB12 RAB12, member RAS oncogene family 0.434524
SELE selectin E 0.427765
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.421765
GSTA3 glutathione S-transferase alpha 3 0.421016
GSTA2 glutathione S-transferase alpha 2 0.419517
GSTA4 glutathione S-transferase alpha 4 0.418394
MMP3 matrix metallopeptidase 3 0.413901
GSTA1 glutathione S-transferase alpha 1 0.412779
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.40904
CMA1 chymase 1, mast cell 0.404931
SEC23A Sec23 homolog A (S. cerevisiae) 0.401572
CXCL8 chemokine (C-X-C motif) ligand 8 0.397843
KIF27 kinesin family member 27 0.390397
DSC2 desmocollin 2 0.389281
TGFB1 transforming growth factor, beta 1 0.386679
PLEC plectin 0.386679
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.386308
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.384079
BASP1 brain abundant, membrane attached signal protein 1 0.378885
F8 coagulation factor VIII, procoagulant component 0.378885
MMP7 matrix metallopeptidase 7 0.37629
ICAM1 intercellular adhesion molecule 1 0.368518
TNF tumor necrosis factor 0.365562
C4A complement component 4A (Rodgers blood group) 0.36187
FCGRT Fc fragment of IgG, receptor, transporter, alpha 0.352291
KRT4 keratin 4, type II 0.345308
KITLG KIT ligand 0.33651
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.334681
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.320817
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.318635
PKP3 plakophilin 3 0.317182
PRLH prolactin releasing hormone 0.316819
CCL17 chemokine (C-C motif) ligand 17 0.316092
HAND2 heart and neural crest derivatives expressed 2 0.316092
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.313552
MUC16 mucin 16, cell surface associated 0.296931
TRAC T cell receptor alpha constant 0.291898
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 0.290103
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.288668
IL13 interleukin 13 0.287593
NISCH nischarin 0.287235
ADAM9 ADAM metallopeptidase domain 9 0.284728
F3 coagulation factor III (thromboplastin, tissue factor) 0.279367
GOSR2 golgi SNAP receptor complex member 2 0.278654
AHNAK AHNAK nucleoprotein 0.275801
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.271886
CD40 CD40 molecule, TNF receptor superfamily member 5 0.268687
CCL13 chemokine (C-C motif) ligand 13 0.266913
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 0.266203
TPMT thiopurine S-methyltransferase 0.263368
PA2G4 proliferation-associated 2G4, 38kDa 0.261952
MPO myeloperoxidase 0.257711
MMP1 matrix metallopeptidase 1 0.246799
FRK fyn-related Src family tyrosine kinase 0.246448
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.245396
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.242945
SEBOX SEBOX homeobox 0.240148
IGKV1D-42 immunoglobulin kappa variable 1D-42 (non-functional) 0.238403
IL4I1 interleukin 4 induced 1 0.237357
VCL vinculin 0.235964
WARS tryptophanyl-tRNA synthetase 0.235964
ADAM19 ADAM metallopeptidase domain 19 0.232489
CCL11 chemokine (C-C motif) ligand 11 0.230409
LAMA5 laminin, alpha 5 0.222822
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.221793
CTSG cathepsin G 0.218374
HDAC4 histone deacetylase 4 0.216672
ALB albumin 0.209918
TIMP1 TIMP metallopeptidase inhibitor 1 0.208579
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.208245
CD40LG CD40 ligand 0.208245
NID2 nidogen 2 (osteonidogen) 0.207578
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.207245
HLA-A major histocompatibility complex, class I, A 0.206248
CTBS chitobiase, di-N-acetyl- 0.199356
GPR135 G protein-coupled receptor 135 0.19742
LIM2 lens intrinsic membrane protein 2, 19kDa 0.196459
MMP12 matrix metallopeptidase 12 0.195501
LOR loricrin 0.192344
TRAF5 TNF receptor-associated factor 5 0.190168
MYO9B myosin IXB 0.188632
LCT lactase 0.188326
JUP junction plakoglobin 0.184128
IL2 interleukin 2 0.180367
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 0.174881
IL1B interleukin 1, beta 0.174354
CFH complement factor H 0.172544
DPP4 dipeptidyl-peptidase 4 0.172038
FSTL1 follistatin-like 1 0.171535
HP haptoglobin 0.171036
HPR haptoglobin-related protein 0.167224
GIF gastric intrinsic factor (vitamin B synthesis) 0.162707
F2 coagulation factor II (thrombin) 0.162505
KERA keratocan 0.161523
IL10 interleukin 10 0.159658
COL4A2 collagen, type IV, alpha 2 0.141402
CMKLR1 chemerin chemokine-like receptor 1 0.139974
PEG3 paternally expressed 3 0.13954
GLS2 glutaminase 2 (liver, mitochondrial) 0.138941
PTH parathyroid hormone 0.137288
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.134719
MUC7 mucin 7, secreted 0.133812
COL4A6 collagen, type IV, alpha 6 0.133588
MED28 mediator complex subunit 28 0.13219
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.131666
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.12959
HECA headcase homolog (Drosophila) 0.12881
FUT2 fucosyltransferase 2 (secretor status included) 0.128449
COL4A4 collagen, type IV, alpha 4 0.127613
COL4A1 collagen, type IV, alpha 1 0.127592
PTGFR prostaglandin F receptor (FP) 0.126937
PRTN3 proteinase 3 0.126894
IFNG interferon, gamma 0.126453
IFI16 interferon, gamma-inducible protein 16 0.126408
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 0.126386
GAST gastrin 0.124671
GNG8 guanine nucleotide binding protein (G protein), gamma 8 0.123251
HLA-B major histocompatibility complex, class I, B 0.123142
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.123085
CD8A CD8a molecule 0.121791
LUM lumican 0.118322
HYLS1 hydrolethalus syndrome 1 0.117021
TSPO translocator protein (18kDa) 0.116908
FOXP3 forkhead box P3 0.116832
LAG3 lymphocyte-activation gene 3 0.116644
TLR5 toll-like receptor 5 0.116343
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.115994
ALPI alkaline phosphatase, intestinal 0.114967
PRODH proline dehydrogenase (oxidase) 1 0.114967
CD68 CD68 molecule 0.114356
TIMP2 TIMP metallopeptidase inhibitor 2 0.114356
LAX1 lymphocyte transmembrane adaptor 1 0.114232
TGM1 transglutaminase 1 0.113607
LAD1 ladinin 1 0.113479
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.113479
PCDH8 protocadherin 8 0.113053
GPHA2 glycoprotein hormone alpha 2 0.112706
PSAT1 phosphoserine aminotransferase 1 0.112267
LTF lactotransferrin 0.111597
IGH immunoglobulin heavy locus 0.111054
CD22 CD22 molecule 0.111054
CKAP5 cytoskeleton associated protein 5 0.110961
CD1B CD1b molecule 0.110682
CFB complement factor B 0.110403
DCXR dicarbonyl/L-xylulose reductase 0.110403
ZNF436 zinc finger protein 436 0.10979
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 0.10979
SIX1 SIX homeobox 1 0.109646