autoimmune disease of gastrointestinal tract Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the gastrointestinal tract. (Human Disease Ontology, DOID_0060031)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:0060031
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Genes

208 genes associated with the disease autoimmune disease of gastrointestinal tract in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.55968
LPP LIM domain containing preferred translocation partner in lipoma 2.54818
KIAA1109 KIAA1109 2.20601
SH2B3 SH2B adaptor protein 3 2.04056
ATXN2 ataxin 2 2.03641
PTPRK protein tyrosine phosphatase, receptor type, K 1.95755
ZMIZ1 zinc finger, MIZ-type containing 1 1.88503
PUS10 pseudouridylate synthase 10 1.85141
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 1.84833
TAGAP T-cell activation RhoGTPase activating protein 1.81474
TRAF1 TNF receptor-associated factor 1 1.75993
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.68078
PTPN2 protein tyrosine phosphatase, non-receptor type 2 1.65612
MMEL1 membrane metallo-endopeptidase-like 1 1.65417
ANKRD55 ankyrin repeat domain 55 1.63944
IL2RA interleukin 2 receptor, alpha 1.63004
CCR6 chemokine (C-C motif) receptor 6 1.62834
CD247 CD247 molecule 1.62029
TNPO3 transportin 3 1.60057
YDJC YdjC homolog (bacterial) 1.54533
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.53785
STAT4 signal transducer and activator of transcription 4 1.53704
SPRED2 sprouty-related, EVH1 domain containing 2 1.52889
IRF4 interferon regulatory factor 4 1.49081
ICOSLG inducible T-cell co-stimulator ligand 1.48714
CD40 CD40 molecule, TNF receptor superfamily member 5 1.47528
UBASH3A ubiquitin associated and SH3 domain containing A 1.47287
ICOS inducible T-cell co-stimulator 1.44922
PLEK pleckstrin 1.43667
ARHGAP31 Rho GTPase activating protein 31 1.43537
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.41627
KIF5A kinesin family member 5A 1.40141
UBE2L3 ubiquitin-conjugating enzyme E2L 3 1.39687
ELMO1 engulfment and cell motility 1 1.39148
C1ORF106 chromosome 1 open reading frame 106 1.38067
TMEM187 transmembrane protein 187 1.37871
C5ORF30 chromosome 5 open reading frame 30 1.35709
FAM107A family with sequence similarity 107, member A 1.35132
ZFP36L1 ZFP36 ring finger protein-like 1 1.35025
NFIA nuclear factor I/A 1.31635
FRMD4B FERM domain containing 4B 1.28906
GLB1 galactosidase, beta 1 1.28041
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 1.27258
PPP1R12B protein phosphatase 1, regulatory subunit 12B 1.26953
MYNN myoneurin 1.24194
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 1.22596
IFI16 interferon, gamma-inducible protein 16 1.21019
WNT3 wingless-type MMTV integration site family, member 3 1.19386
TPTE transmembrane phosphatase with tensin homology 1.14463
CD28 CD28 molecule 1.14182
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 1.11813
TG thyroglobulin 1.10419
ALPK2 alpha-kinase 2 1.08533
RUNX3 runt-related transcription factor 3 1.08211
MTTP microsomal triglyceride transfer protein 1.04846
KLK2 kallikrein-related peptidase 2 1.02476
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 1.00886
HYDIN HYDIN, axonemal central pair apparatus protein 1.00407
STK32B serine/threonine kinase 32B 0.986376
TGFBR3 transforming growth factor, beta receptor III 0.982352
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 0.951514
CNTN4 contactin 4 0.947208
PRKCZ protein kinase C, zeta 0.946163
NTM neurotrimin 0.940135
LINC00466 long intergenic non-protein coding RNA 466 0.888428
IL18RAP interleukin 18 receptor accessory protein 0.877396
NUP98 nucleoporin 98kDa 0.869084
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.865448
GFRA1 GDNF family receptor alpha 1 0.861462
LOC284395 uncharacterized LOC284395 0.853791
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.845188
PTCHD4 patched domain containing 4 0.842929
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.839855
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 0.837718
MTCH1 mitochondrial carrier 1 0.823134
ITPK1 inositol-tetrakisphosphate 1-kinase 0.818753
RYR3 ryanodine receptor 3 0.815307
POU2F1 POU class 2 homeobox 1 0.808055
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.806323
LINGO2 leucine rich repeat and Ig domain containing 2 0.801304
FOXD3 forkhead box D3 0.79563
RGS1 regulator of G-protein signaling 1 0.79563
MAML3 mastermind-like 3 (Drosophila) 0.787593
ARHGAP44 Rho GTPase activating protein 44 0.786312
BCRP2 breakpoint cluster region pseudogene 2 0.777475
LTF lactotransferrin 0.769887
TSPAN18 tetraspanin 18 0.769887
WWOX WW domain containing oxidoreductase 0.769617
TIPRL TOR signaling pathway regulator 0.767882
FERMT1 fermitin family member 1 0.76125
BTN3A2 butyrophilin, subfamily 3, member A2 0.753433
CCDC91 coiled-coil domain containing 91 0.747619
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.743756
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.743048
DNAH8 dynein, axonemal, heavy chain 8 0.743048
PGM1 phosphoglucomutase 1 0.740032
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 0.736216
MOB3B MOB kinase activator 3B 0.727538
BCL2 B-cell CLL/lymphoma 2 0.7253
THEMIS thymocyte selection associated 0.720532
KIFAP3 kinesin-associated protein 3 0.712762
KCNK10 potassium channel, two pore domain subfamily K, member 10 0.70719
PCDH11Y protocadherin 11 Y-linked 0.707003
SNED1 sushi, nidogen and EGF-like domains 1 0.70663
UNC5C unc-5 homolog C (C. elegans) 0.70663
ADGRL2 adhesion G protein-coupled receptor L2 0.705703
MACROD2 MACRO domain containing 2 0.699446
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.698071
LOH12CR1 loss of heterozygosity, 12, chromosomal region 1 0.691618
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 0.691297
POLN polymerase (DNA directed) nu 0.689711
LCT lactase 0.687994
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.683898
OPHN1 oligophrenin 1 0.675623
MYO5A myosin VA (heavy chain 12, myoxin) 0.673322
ALG9 ALG9, alpha-1,2-mannosyltransferase 0.672258
VAV3 vav 3 guanine nucleotide exchange factor 0.671993
ZNF496 zinc finger protein 496 0.669747
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.665868
KIAA1644 KIAA1644 0.663947
CPM carboxypeptidase M 0.660239
FFAR4 free fatty acid receptor 4 0.658446
NCR2 natural cytotoxicity triggering receptor 2 0.656693
WT1 Wilms tumor 1 0.656693
NELL1 NEL-like 1 (chicken) 0.655831
PDE8A phosphodiesterase 8A 0.651654
SHISA9 shisa family member 9 0.650844
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.650844
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.647686
FAM24A family with sequence similarity 24, member A 0.644215
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.642063
LAMA2 laminin, alpha 2 0.641537
WSCD1 WSC domain containing 1 0.641537
DNAH12 dynein, axonemal, heavy chain 12 0.639985
HPSE2 heparanase 2 (inactive) 0.636995
KANK4 KN motif and ankyrin repeat domains 4 0.636511
LIN7A lin-7 homolog A (C. elegans) 0.634612
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 0.632771
VIM vimentin 0.631872
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.629714
UROC1 urocanate hydratase 1 0.628481
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.626482
PKN2 protein kinase N2 0.624931
CARD11 caspase recruitment domain family, member 11 0.623422
NTNG1 netrin G1 0.622315
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.620165
PPARA peroxisome proliferator-activated receptor alpha 0.61912
ATXN1 ataxin 1 0.618434
BMPR1B bone morphogenetic protein receptor, type IB 0.617086
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 0.616754
TGFB2 transforming growth factor, beta 2 0.615445
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.615445
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 0.614068
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.613722
UBE2Q2P1 ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 1 0.613722
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.612357
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene) 0.611686
PVR poliovirus receptor 0.611686
BID BH3 interacting domain death agonist 0.611023
RGS10 regulator of G-protein signaling 10 0.605359
BTN2A1 butyrophilin, subfamily 2, member A1 0.60506
TGM3 transglutaminase 3 0.60506
GRIK4 glutamate receptor, ionotropic, kainate 4 0.604465
PRR5L proline rich 5 like 0.603584
KIAA1217 KIAA1217 0.603005
LOC100506274 uncharacterized LOC100506274 0.60243
OR51E2 olfactory receptor, family 51, subfamily E, member 2 0.601018
E2F3 E2F transcription factor 3 0.601018
ADI1 acireductone dioxygenase 1 0.59964
SOX2-OT SOX2 overlapping transcript 0.599097
PDPN podoplanin 0.598827
VWC2L von Willebrand factor C domain containing protein 2-like 0.596242
CAPN14 calpain 14 0.595401
METTL18 methyltransferase like 18 0.594847
CAGE1 cancer antigen 1 0.594297
DNAH14 dynein, axonemal, heavy chain 14 0.592411
PRUNE2 prune homolog 2 (Drosophila) 0.592146
FAM135B family with sequence similarity 135, member B 0.592146
VSTM4 V-set and transmembrane domain containing 4 0.591358
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.591098
DOK6 docking protein 6 0.591098
ADRA1B adrenoceptor alpha 1B 0.590323
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 0.590323
TFIP11 tuftelin interacting protein 11 0.589557
DGKG diacylglycerol kinase, gamma 90kDa 0.588801
KIAA0319 KIAA0319 0.588551
NUAK1 NUAK family, SNF1-like kinase, 1 0.588551
SRRD SRR1 domain containing 0.588302
NRXN3 neurexin 3 0.587807
IGSF23 immunoglobulin superfamily, member 23 0.587071
MAGED1 melanoma antigen family D1 0.587071
MIER1 mesoderm induction early response 1, transcriptional regulator 0.57331
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.566055
SIL1 SIL1 nucleotide exchange factor 0.560729
SYT1 synaptotagmin I 0.552872
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.549267
MIR99AHG mir-99a-let-7c cluster host gene 0.545697
PRDM10 PR domain containing 10 0.542281
NRROS negative regulator of reactive oxygen species 0.541213
COX20 COX20 cytochrome c oxidase assembly factor 0.539271
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.538104
PRAM1 PML-RARA regulated adaptor molecule 1 0.535408
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.533758
DCN decorin 0.531096
RNF213 ring finger protein 213 0.52333
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 0.501764
ARMC9 armadillo repeat containing 9 0.500605
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta 0.499347