attention deficit hyperactivity disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone and symptoms starting before seven years of age. (Human Disease Ontology, DOID_1094)
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Genes

282 genes co-occuring with the disease attention deficit hyperactivity disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
DRD4 dopamine receptor D4 3.02271
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.87313
DRD5 dopamine receptor D5 2.27479
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.21217
ADRA2A adrenoceptor alpha 2A 1.91127
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.81736
COMT catechol-O-methyltransferase 1.81645
ADGRL3 adhesion G protein-coupled receptor L3 1.68997
EFS embryonal Fyn-associated substrate 1.68408
MAOA monoamine oxidase A 1.65565
HRH3 histamine receptor H3 1.55912
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.54407
DRD2 dopamine receptor D2 1.53524
SNAP25 synaptosomal-associated protein, 25kDa 1.53392
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.44474
BDNF brain-derived neurotrophic factor 1.3821
IMPACT impact RWD domain protein 1.37643
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.37381
ADRA2C adrenoceptor alpha 2C 1.36117
THRB thyroid hormone receptor, beta 1.33981
CALY calcyon neuron-specific vesicular protein 1.33676
SNAP23 synaptosomal-associated protein, 23kDa 1.29571
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 1.28173
MRPL49 mitochondrial ribosomal protein L49 1.24993
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.2495
DRD1 dopamine receptor D1 1.24863
TH tyrosine hydroxylase 1.2369
GFOD1 glucose-fructose oxidoreductase domain containing 1 1.20569
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 1.20396
GRM7 glutamate receptor, metabotropic 7 1.19489
INTS8 integrator complex subunit 8 1.18669
ZBBX zinc finger, B-box domain containing 1.15283
DRD3 dopamine receptor D3 1.1456
KARS lysyl-tRNA synthetase 1.12108
TPH2 tryptophan hydroxylase 2 1.10343
NF1 neurofibromin 1 1.09881
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 1.0795
ASTN2 astrotactin 2 1.06816
FAM168B family with sequence similarity 168, member B 1.06774
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.06396
C4ORF48 chromosome 4 open reading frame 48 1.06102
PNPLA4 patatin-like phospholipase domain containing 4 1.05765
ADD2 adducin 2 (beta) 1.05345
DAD1 defender against cell death 1 1.04756
HOMER1 homer scaffolding protein 1 1.04546
AMER3 APC membrane recruitment protein 3 1.04167
STS steroid sulfatase (microsomal), isozyme S 1.03704
TAAR1 trace amine associated receptor 1 1.01047
C17ORF67 chromosome 17 open reading frame 67 0.982215
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.976744
CLEC19A C-type lectin domain family 19, member A 0.952856
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.952856
LXN latexin 0.947435
TXNRD2 thioredoxin reductase 2 0.944938
BTBD9 BTB (POZ) domain containing 9 0.931242
PRTG protogenin 0.917199
BPI bactericidal/permeability-increasing protein 0.901978
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.900335
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.890898
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.889668
ADRA1A adrenoceptor alpha 1A 0.881062
FMR1 fragile X mental retardation 1 0.877786
TRIM32 tripartite motif containing 32 0.876966
TPH1 tryptophan hydroxylase 1 0.8741
FOS FBJ murine osteosarcoma viral oncogene homolog 0.872872
SLC22A23 solute carrier family 22, member 23 0.863046
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.854859
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.851992
PEG10 paternally expressed 10 0.846669
PABPC5 poly(A) binding protein, cytoplasmic 5 0.842163
MACROD2 MACRO domain containing 2 0.840525
DCLK2 doublecortin-like kinase 2 0.825768
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 0.823308
CLOCK clock circadian regulator 0.816334
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.783116
ASTN1 astrotactin 1 0.772887
NTAN1 N-terminal asparagine amidase 0.772479
STX12 syntaxin 12 0.767576
MAOB monoamine oxidase B 0.749644
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) 0.732596
SYT1 synaptotagmin I 0.719654
TACR1 tachykinin receptor 1 0.704742
GRIK5 glutamate receptor, ionotropic, kainate 5 0.690694
NLGN4X neuroligin 4, X-linked 0.678302
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.670333
NKG7 natural killer cell granule protein 7 0.66914
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.655254
KLHL12 kelch-like family member 12 0.646559
PTCHD1 patched domain containing 1 0.644192
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 0.642615
C4B complement component 4B (Chido blood group) 0.635528
TDO2 tryptophan 2,3-dioxygenase 0.635135
FAM215A family with sequence similarity 215, member A (non-protein coding) 0.633169
CES1 carboxylesterase 1 0.63042
ADRA2B adrenoceptor alpha 2B 0.628065
SORCS3 sortilin-related VPS10 domain containing receptor 3 0.620226
SKOR1 SKI family transcriptional corepressor 1 0.61866
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.613183
ADRA1D adrenoceptor alpha 1D 0.612792
FGGY FGGY carbohydrate kinase domain containing 0.610838
NRXN1 neurexin 1 0.610838
GJB6 gap junction protein, beta 6, 30kDa 0.606543
ADORA2A adenosine A2a receptor 0.596402
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 0.587054
SYN3 synapsin III 0.585497
CORT cortistatin 0.576161
FLRT3 fibronectin leucine rich transmembrane protein 3 0.573439
CES3 carboxylesterase 3 0.571495
SV2C synaptic vesicle glycoprotein 2C 0.566054
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 0.560227
PRKG1 protein kinase, cGMP-dependent, type I 0.556344
SYT12 synaptotagmin XII 0.555956
ARRB2 arrestin, beta 2 0.555956
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 0.552851
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.545093
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) 0.53928
PCDH11X protocadherin 11 X-linked 0.524974
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.522659
CSNK1A1 casein kinase 1, alpha 1 0.522659
DLG1 discs, large homolog 1 (Drosophila) 0.518805
STX1A syntaxin 1A (brain) 0.491215
KAT6B K(lysine) acetyltransferase 6B 0.490835
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.484744
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.478289
FTH1 ferritin, heavy polypeptide 1 0.478289
FTL ferritin, light polypeptide 0.478289
PGRMC2 progesterone receptor membrane component 2 0.47753
AUTS2 autism susceptibility candidate 2 0.473361
ACPT acid phosphatase, testicular 0.471468
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 0.471089
SYT11 synaptotagmin XI 0.470332
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.466928
TAC1 tachykinin, precursor 1 0.46655
AGTRAP angiotensin II receptor-associated protein 0.465794
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 0.462016
ACP1 acid phosphatase 1, soluble 0.445052
AQP6 aquaporin 6, kidney specific 0.445052
NFIL3 nuclear factor, interleukin 3 regulated 0.4443
ELP4 elongator acetyltransferase complex subunit 4 0.433021
DPF2 D4, zinc and double PHD fingers family 2 0.431894
OPRD1 opioid receptor, delta 1 0.431144
CNTN4 contactin 4 0.429642
STAU1 staufen double-stranded RNA binding protein 1 0.429642
MECP2 methyl CpG binding protein 2 0.425514
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 0.425514
SYT2 synaptotagmin II 0.424389
DOCK3 dedicator of cytokinesis 3 0.42364
B3GALTL beta 1,3-galactosyltransferase-like 0.41465
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.405678
CARTPT CART prepropeptide 0.403064
CNR1 cannabinoid receptor 1 (brain) 0.402318
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 0.396725
LHX1 LIM homeobox 1 0.394863
APLN apelin 0.394491
MAP2K5 mitogen-activated protein kinase kinase 5 0.392629
GRM5 glutamate receptor, metabotropic 5 0.390397
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.379256
IQCB1 IQ motif containing B1 0.378514
ZBTB20 zinc finger and BTB domain containing 20 0.378514
PITX3 paired-like homeodomain 3 0.374068
GLRA2 glycine receptor, alpha 2 0.373328
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.372958
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 0.372958
CIB1 calcium and integrin binding 1 (calmyrin) 0.367779
PCSK5 proprotein convertase subtilisin/kexin type 5 0.36704
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.365932
DARS aspartyl-tRNA synthetase 0.364824
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.363716
CUL4B cullin 4B 0.362609
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 0.360764
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 0.359657
NTF3 neurotrophin 3 0.355235
MSI2 musashi RNA-binding protein 2 0.354131
CPLX2 complexin 2 0.348246
IFI44L interferon-induced protein 44-like 0.344941
PDYN prodynorphin 0.343106
AVPR1A arginine vasopressin receptor 1A 0.336876
HES6 hes family bHLH transcription factor 6 0.331025
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.33066
HCRT hypocretin (orexin) neuropeptide precursor 0.330295
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.328469
FGF10 fibroblast growth factor 10 0.326281
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.324458
POMC proopiomelanocortin 0.321545
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.318272
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.318272
SLITRK1 SLIT and NTRK-like family, member 1 0.313189
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.307395
CARS cysteinyl-tRNA synthetase 0.306672
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.30342
TSC2 tuberous sclerosis 2 0.302698
NRXN3 neurexin 3 0.302337
AVP arginine vasopressin 0.298731
CNTFR ciliary neurotrophic factor receptor 0.297291
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.296571
PRKCG protein kinase C, gamma 0.296211
PICK1 protein interacting with PRKCA 1 0.295851
CNTNAP2 contactin associated protein-like 2 0.292975
HES1 hes family bHLH transcription factor 1 0.290462
FAM195A family with sequence similarity 195, member A 0.290103
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.289744
NDE1 nudE neurodevelopment protein 1 0.28831
TBR1 T-box, brain, 1 0.286519
GRM8 glutamate receptor, metabotropic 8 0.281868
GRM6 glutamate receptor, metabotropic 6 0.281153
PIR pirin (iron-binding nuclear protein) 0.280439
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 0.280439
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.27687
ADCY7 adenylate cyclase 7 0.275445
WRNIP1 Werner helicase interacting protein 1 0.271174
FGD1 FYVE, RhoGEF and PH domain containing 1 0.270464
ACD adrenocortical dysplasia homolog (mouse) 0.266913
MFF mitochondrial fission factor 0.266913
CDH13 cadherin 13 0.262306
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.259477
NCS1 neuronal calcium sensor 1 0.25877
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.258417
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 0.257711
EPHA5 EPH receptor A5 0.255946
ADRA1B adrenoceptor alpha 1B 0.255594
NRG3 neuregulin 3 0.250311
ASMT acetylserotonin O-methyltransferase 0.24996
EMX2 empty spiracles homeobox 2 0.248203
PNKD paroxysmal nonkinesigenic dyskinesia 0.24715
TENM1 teneurin transmembrane protein 1 0.244696
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 0.241546
ARSE arylsulfatase E (chondrodysplasia punctata 1) 0.238403
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.237357
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.236312
CORO1A coronin, actin binding protein, 1A 0.233183
GALR2 galanin receptor 2 0.227988
S100B S100 calcium binding protein B 0.224884
GRM1 glutamate receptor, metabotropic 1 0.224884
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 0.223509
DYX1C1 dyslexia susceptibility 1 candidate 1 0.222479
FLNA filamin A, alpha 0.21974
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.21974
DAOA D-amino acid oxidase activator 0.218715
GPR148 G protein-coupled receptor 148 0.218034
MOGS mannosyl-oligosaccharide glucosidase 0.217693
ADRB2 adrenoceptor beta 2, surface 0.217352
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.214975
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.214636
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 0.213621
ZNF804A zinc finger protein 804A 0.213283
SMC1A structural maintenance of chromosomes 1A 0.209248
OTC ornithine carbamoyltransferase 0.208579
PTGFR prostaglandin F receptor (FP) 0.206913
ITGA1 integrin, alpha 1 0.20658
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.20229
EDA ectodysplasin A 0.200006
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 0.198064
NPY neuropeptide Y 0.197099
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 0.19582
PRRT2 proline-rich transmembrane protein 2 0.193915
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.191719
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.189244
PER1 period circadian clock 1 0.188938
HOPX HOP homeobox 0.187719
PRRC2A proline-rich coiled-coil 2A 0.184424
FNDC3A fibronectin type III domain containing 3A 0.181798
PANK1 pantothenate kinase 1 0.178682
WASF3 WAS protein family, member 3 0.177576
NLRP12 NLR family, pyrin domain containing 12 0.177301
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.177029
MON1A MON1 secretory trafficking family member A 0.174881
LGALS8 lectin, galactoside-binding, soluble, 8 0.173571
BCHE butyrylcholinesterase 0.172799
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 0.172038
OPRM1 opioid receptor, mu 1 0.171785
IGBP1 immunoglobulin (CD79A) binding protein 1 0.170054
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 0.170054
MIR96 microRNA 96 0.169571
NTS neurotensin 0.168381
HDAC5 histone deacetylase 5 0.166995
GRB10 growth factor receptor-bound protein 10 0.166095
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.163111
SCP2 sterol carrier protein 2 0.160948
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.159302
MIR183 microRNA 183 0.158778
PLCH2 phospholipase C, eta 2 0.158097
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 0.158097