atropine oxide-4476 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the atropine oxide-4476 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRG1 adhesion G protein-coupled receptor G1
AIRE autoimmune regulator
AKAP8L A kinase (PRKA) anchor protein 8-like
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
ARHGAP35 Rho GTPase activating protein 35
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BAAT bile acid CoA:amino acid N-acyltransferase
CA9 carbonic anhydrase IX
CACFD1 calcium channel flower domain containing 1
CALML3 calmodulin-like 3
CARD10 caspase recruitment domain family, member 10
CD58 CD58 molecule
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CNR2 cannabinoid receptor 2 (macrophage)
CROCCP3 ciliary rootlet coiled-coil, rootletin pseudogene 3
CUZD1 CUB and zona pellucida-like domains 1
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DOCK10 dedicator of cytokinesis 10
DTNA dystrobrevin, alpha
EGR1 early growth response 1
ELF5 E74-like factor 5 (ets domain transcription factor)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FGFR4 fibroblast growth factor receptor 4
FKRP fukutin related protein
FMO2 flavin containing monooxygenase 2 (non-functional)
FRS3 fibroblast growth factor receptor substrate 3
FXYD7 FXYD domain containing ion transport regulator 7
GLP1R glucagon-like peptide 1 receptor
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GNRH2 gonadotropin-releasing hormone 2
GREB1L growth regulation by estrogen in breast cancer-like
GRIK5 glutamate receptor, ionotropic, kainate 5
GRK5 G protein-coupled receptor kinase 5
HEXIM1 hexamethylene bis-acetamide inducible 1
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
ICOSLG inducible T-cell co-stimulator ligand
IFT122 intraflagellar transport 122
INTS1 integrator complex subunit 1
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JUND jun D proto-oncogene
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
LAMC3 laminin, gamma 3
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LRRC15 leucine rich repeat containing 15
MAN2A2 mannosidase, alpha, class 2A, member 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K19 mitogen-activated protein kinase kinase kinase 19
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MEF2D myocyte enhancer factor 2D
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP3 matrix metallopeptidase 3
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYH11 myosin, heavy chain 11, smooth muscle
MYOM2 myomesin 2
MYT1 myelin transcription factor 1
NCOR2 nuclear receptor corepressor 2
NEO1 neogenin 1
NOD2 nucleotide-binding oligomerization domain containing 2
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR2F6 nuclear receptor subfamily 2, group F, member 6
NSUN6 NOP2/Sun domain family, member 6
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDIA2 protein disulfide isomerase family A, member 2
PDLIM3 PDZ and LIM domain 3
PPARD peroxisome proliferator-activated receptor delta
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB6B RAB6B, member RAS oncogene family
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
RUNX1 runt-related transcription factor 1
SCN3B sodium channel, voltage gated, type III beta subunit
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SHOX2 short stature homeobox 2
SIX3 SIX homeobox 3
SKAP1 src kinase associated phosphoprotein 1
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SRRT serrate, RNA effector molecule
TAPT1 transmembrane anterior posterior transformation 1
TAS2R10 taste receptor, type 2, member 10
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TCP10 t-complex 10
TET3 tet methylcytosine dioxygenase 3
THRB thyroid hormone receptor, beta
TLDC1 TBC/LysM-associated domain containing 1
TP53I11 tumor protein p53 inducible protein 11
TRIM15 tripartite motif containing 15
TUBA3D tubulin, alpha 3d
UST uronyl-2-sulfotransferase
VAV2 vav 2 guanine nucleotide exchange factor
YY2 YY2 transcription factor
ZNF41 zinc finger protein 41

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AEN apoptosis enhancing nuclease
AMT aminomethyltransferase
ARHGAP12 Rho GTPase activating protein 12
AVEN apoptosis, caspase activation inhibitor
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BEX1 brain expressed, X-linked 1
C22ORF29 chromosome 22 open reading frame 29
C5 complement component 5
CCDC68 coiled-coil domain containing 68
CDT1 chromatin licensing and DNA replication factor 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP295 centrosomal protein 295kDa
COBL cordon-bleu WH2 repeat protein
CPEB1 cytoplasmic polyadenylation element binding protein 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCAF17 DDB1 and CUL4 associated factor 17
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEPTOR DEP domain containing MTOR-interacting protein
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FGGY FGGY carbohydrate kinase domain containing
FSD1 fibronectin type III and SPRY domain containing 1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPATCH2 G patch domain containing 2
GSTCD glutathione S-transferase, C-terminal domain containing
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HIST1H4C histone cluster 1, H4c
HLA-DMA major histocompatibility complex, class II, DM alpha
HOXA1 homeobox A1
HOXB9 homeobox B9
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IER3IP1 immediate early response 3 interacting protein 1
IFI6 interferon, alpha-inducible protein 6
IL17RA interleukin 17 receptor A
LINS lines homolog (Drosophila)
LY86 lymphocyte antigen 86
MAGEF1 melanoma antigen family F1
MANBA mannosidase, beta A, lysosomal
MAP6D1 MAP6 domain containing 1
MB myoglobin
MED18 mediator complex subunit 18
MGC12488
MOCS3 molybdenum cofactor synthesis 3
MON1B MON1 secretory trafficking family member B
MOXD1 monooxygenase, DBH-like 1
MTMR12 myotubularin related protein 12
MUC3A mucin 3A, cell surface associated
MX1 MX dynamin-like GTPase 1
MXRA8 matrix-remodelling associated 8
MYL5 myosin, light chain 5, regulatory
NARFL nuclear prelamin A recognition factor-like
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae)
NPY1R neuropeptide Y receptor Y1
NTSR1 neurotensin receptor 1 (high affinity)
NUP62CL nucleoporin 62kDa C-terminal like
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PHF11 PHD finger protein 11
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRR7 proline rich 7 (synaptic)
QTRT1 queuine tRNA-ribosyltransferase 1
RAD51AP1 RAD51 associated protein 1
RASA2 RAS p21 protein activator 2
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPIN1 spindlin 1
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STX18 syntaxin 18
SYT17 synaptotagmin XVII
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
THBS3 thrombospondin 3
TMEM53 transmembrane protein 53
TRPV1 transient receptor potential cation channel, subfamily V, member 1
USP8 ubiquitin specific peptidase 8
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VASH2 vasohibin 2
VEZT vezatin, adherens junctions transmembrane protein
WDR76 WD repeat domain 76
ZC3H12A zinc finger CCCH-type containing 12A
ZHX2 zinc fingers and homeoboxes 2
ZNF112 zinc finger protein 112
ZNF230 zinc finger protein 230
ZNF253 zinc finger protein 253
ZNF286A zinc finger protein 286A
ZNF350 zinc finger protein 350
ZNF551 zinc finger protein 551
ZNF770 zinc finger protein 770