atm signaling pathway Gene Set

Dataset Biocarta Pathways
Category structural or functional annotations
Type pathway
Description The ataxia telangiectasia-mutated (ATM) serine/threonine kinase mediated signaling plays a major role in the response to DNA double strand breaks (DSB). Following lesion sensing by the MRN complex, ATM gets activated. Active ATM phosphorylates itself and targets resulting in triggering of DNA repair, cell cycle checkpoint and signaling pathways. While ATM signaling is best documented for its role in DSB responses, evidence accumulates that it functions in a range of other, DNA damage unrelated, responses. (Pathway Ontology, PW_0001361)
External Link http://cgap.nci.nih.gov/Pathways/BioCarta/h_atmPathway
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Genes

18 proteins participating in the atm signaling pathway pathway from the Biocarta Pathways dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BRCA1 breast cancer 1, early onset
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
GADD45A growth arrest and DNA-damage-inducible, alpha
JUN jun proto-oncogene
MAPK8 mitogen-activated protein kinase 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
RAD51 RAD51 recombinase
RBBP8 retinoblastoma binding protein 8
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPA1 replication protein A1, 70kDa
TP53 tumor protein p53
TP73 tumor protein p73
TREX1 three prime repair exonuclease 1