astrocytoma Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A glial tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and glioblastoma.|Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation (MeSH).|Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082) (Experimental Factor Ontology, EFO_0000272)
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Genes

162 genes co-occuring with the biological term astrocytoma in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTN1 actinin, alpha 1
ACTN4 actinin, alpha 4
ACVR1 activin A receptor, type I
ADM adrenomedullin
ADORA3 adenosine A3 receptor
AGER advanced glycosylation end product-specific receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APP amyloid beta (A4) precursor protein
AQP1 aquaporin 1 (Colton blood group)
AQP4 aquaporin 4
AQP9 aquaporin 9
ASCL1 achaete-scute family bHLH transcription factor 1
ATM ATM serine/threonine kinase
AURKA aurora kinase A
AXIN1 axin 1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BCAN brevican
BDKRB2 bradykinin receptor B2
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA2 breast cancer 2, early onset
CA9 carbonic anhydrase IX
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CD24 CD24 molecule
CD63 CD63 molecule
CDC25B cell division cycle 25B
CDKN2A cyclin-dependent kinase inhibitor 2A
CITED4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
CREB1 cAMP responsive element binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CTSS cathepsin S
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DMBT1 deleted in malignant brain tumors 1
ECT2 epithelial cell transforming 2
EGFR epidermal growth factor receptor
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
F2R coagulation factor II (thrombin) receptor
FAS Fas cell surface death receptor
FLNA filamin A, alpha
FPR2 formyl peptide receptor 2
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GFAP glial fibrillary acidic protein
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GLI1 GLI family zinc finger 1
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GRIK2 glutamate receptor, ionotropic, kainate 2
GSN gelsolin
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFIH1 interferon induced with helicase C domain 1
IFNB1 interferon, beta 1, fibroblast
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL6 interleukin 6
ILK integrin-linked kinase
ING4 inhibitor of growth family, member 4
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JUP junction plakoglobin
KDR kinase insert domain receptor
KIAA1524 KIAA1524
KIAA1549 KIAA1549
LATS1 large tumor suppressor kinase 1
LATS2 large tumor suppressor kinase 2
LPAR6 lysophosphatidic acid receptor 6
MATN2 matrilin 2
MBD3 methyl-CpG binding domain protein 3
MCM7 minichromosome maintenance complex component 7
METAP2 methionyl aminopeptidase 2
MGMT O-6-methylguanine-DNA methyltransferase
MIR200B microRNA 200b
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MVP major vault protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAM1 neural cell adhesion molecule 1
NCAN neurocan
NCOA1 nuclear receptor coactivator 1
NCOA3 nuclear receptor coactivator 3
NDRG2 NDRG family member 2
NES nestin
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NF1 neurofibromin 1
NFIB nuclear factor I/B
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGB neuroglobin
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH2 notch 2
NRN1 neuritin 1
NUMB numb homolog (Drosophila)
OLIG2 oligodendrocyte lineage transcription factor 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARK7 parkinson protein 7
PBX3 pre-B-cell leukemia homeobox 3
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PER1 period circadian clock 1
PGR progesterone receptor
PIBF1 progesterone immunomodulatory binding factor 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK5 polo-like kinase 5
PON1 paraoxonase 1
PRDX1 peroxiredoxin 1
PRDX6 peroxiredoxin 6
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRND prion protein 2 (dublet)
PTCH1 patched 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTTG1 pituitary tumor-transforming 1
PTTG1IP pituitary tumor-transforming 1 interacting protein
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASAL2 RAS protein activator like 2
RHOA ras homolog family member A
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RTEL1 regulator of telomere elongation helicase 1
RTN4R reticulon 4 receptor
SATB1 SATB homeobox 1
SCN5A sodium channel, voltage gated, type V alpha subunit
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SHH sonic hedgehog
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX10 SRY (sex determining region Y)-box 10
SPAG9 sperm associated antigen 9
SPHK1 sphingosine kinase 1
SPP1 secreted phosphoprotein 1
STARD13 StAR-related lipid transfer (START) domain containing 13
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TAC3 tachykinin 3
TBXA2R thromboxane A2 receptor
TERT telomerase reverse transcriptase
TIMP4 TIMP metallopeptidase inhibitor 4
TNC tenascin C
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TPX2 TPX2, microtubule-associated
TSC2 tuberous sclerosis 2
TUBB3 tubulin, beta 3 class III
TUBG1 tubulin, gamma 1
VEGFA vascular endothelial growth factor A
WIF1 WNT inhibitory factor 1
WWOX WW domain containing oxidoreductase