astemizole-2211 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
Similar Terms
Downloads & Tools

Genes

196 genes differentially expressed following the astemizole-2211 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ARC activity-regulated cytoskeleton-associated protein
ARL14 ADP-ribosylation factor-like 14
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCNG2 cyclin G2
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CXCL10 chemokine (C-X-C motif) ligand 10
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EGR4 early growth response 4
ERO1LB ERO1-like beta (S. cerevisiae)
FAM46C family with sequence similarity 46, member C
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAP43 growth associated protein 43
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1T histone cluster 1, H1t
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HIST1H4E histone cluster 1, H4e
HIST1H4H histone cluster 1, H4h
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL21R interleukin 21 receptor
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JUN jun proto-oncogene
KIAA0125 KIAA0125
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK7 mitogen-activated protein kinase 7
MBNL2 muscleblind-like splicing regulator 2
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MVD mevalonate (diphospho) decarboxylase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NF2 neurofibromin 2 (merlin)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLM polymerase (DNA directed), mu
PPARG peroxisome proliferator-activated receptor gamma
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RND1 Rho family GTPase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SOX9 SRY (sex determining region Y)-box 9
SPRY4 sprouty homolog 4 (Drosophila)
SRPK2 SRSF protein kinase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM2 tripartite motif containing 2
TRIM29 tripartite motif containing 29
TXNIP thioredoxin interacting protein
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADAM15 ADAM metallopeptidase domain 15
AR androgen receptor
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
C19ORF73 chromosome 19 open reading frame 73
C1ORF105 chromosome 1 open reading frame 105
C1ORF159 chromosome 1 open reading frame 159
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C9ORF40 chromosome 9 open reading frame 40
C9ORF9 chromosome 9 open reading frame 9
CCNE2 cyclin E2
CD34 CD34 molecule
CDON cell adhesion associated, oncogene regulated
CEL carboxyl ester lipase
CPPED1 calcineurin-like phosphoesterase domain containing 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUZD1 CUB and zona pellucida-like domains 1
DCAF13 DDB1 and CUL4 associated factor 13
DMTN dematin actin binding protein
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DTX2 deltex 2, E3 ubiquitin ligase
E2F8 E2F transcription factor 8
EMID1 EMI domain containing 1
ERCC6L excision repair cross-complementation group 6-like
FAN1 FANCD2/FANCI-associated nuclease 1
FBXW12 F-box and WD repeat domain containing 12
FURIN furin (paired basic amino acid cleaving enzyme)
GLI3 GLI family zinc finger 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRTP1 growth hormone regulated TBC protein 1
GSTCD glutathione S-transferase, C-terminal domain containing
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIST1H3E histone cluster 1, H3e
HOXA4 homeobox A4
IL12RB1 interleukin 12 receptor, beta 1
IL17RA interleukin 17 receptor A
IL17RB interleukin 17 receptor B
IRF2BP1 interferon regulatory factor 2 binding protein 1
KIAA0754 KIAA0754
LOC390998 ribosomal protein L10 pseudogene
LRP3 low density lipoprotein receptor-related protein 3
MAGEB2 melanoma antigen family B2
MAP6D1 MAP6 domain containing 1
MAST3 microtubule associated serine/threonine kinase 3
MBNL3 muscleblind-like splicing regulator 3
MUM1 melanoma associated antigen (mutated) 1
MYOZ1 myozenin 1
NEK11 NIMA-related kinase 11
NRGN neurogranin (protein kinase C substrate, RC3)
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PADI1 peptidyl arginine deiminase, type I
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLAC1 placenta-specific 1
PLD3 phospholipase D family, member 3
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLH polymerase (DNA directed), eta
POM121 POM121 transmembrane nucleoporin
PQLC2 PQ loop repeat containing 2
RAB3D RAB3D, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RGS19 regulator of G-protein signaling 19
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPL23AP32 ribosomal protein L23a pseudogene 32
SAYSD1 SAYSVFN motif domain containing 1
SCN1B sodium channel, voltage gated, type I beta subunit
SEC14L5 SEC14-like 5 (S. cerevisiae)
SECTM1 secreted and transmembrane 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SIPA1 signal-induced proliferation-associated 1
SLC10A3 solute carrier family 10, member 3
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC2A4RG SLC2A4 regulator
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPRYD7 SPRY domain containing 7
STAG3 stromal antigen 3
STARD5 StAR-related lipid transfer (START) domain containing 5
SYNC syncoilin, intermediate filament protein
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TESC tescalcin
TICAM1 toll-like receptor adaptor molecule 1
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM110 transmembrane protein 110
TMEM164 transmembrane protein 164
UNC119 unc-119 homolog (C. elegans)
VGF VGF nerve growth factor inducible
VWA1 von Willebrand factor A domain containing 1
WDR76 WD repeat domain 76
ZIC3 Zic family member 3
ZNF37BP zinc finger protein 37B, pseudogene
ZNF41 zinc finger protein 41