arthritis Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint and/or redness located_in skin over the joint. (Human Disease Ontology, DOID_848)
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Genes

56 genes associated with the disease arthritis in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ACE angiotensin I converting enzyme
CARD8 caspase recruitment domain family, member 8
CCL2 chemokine (C-C motif) ligand 2
CD44 CD44 molecule (Indian blood group)
CRH corticotropin releasing hormone
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
HFE hemochromatosis
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
ICAM1 intercellular adhesion molecule 1
IFNA1 interferon, alpha 1
IFNG interferon, gamma
IL10 interleukin 10
IL11RA interleukin 11 receptor, alpha
IL12A interleukin 12A
IL15 interleukin 15
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL3 interleukin 3
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IRF1 interferon regulatory factor 1
LTA lymphotoxin alpha
MBL2 mannose-binding lectin (protein C) 2, soluble
MEFV Mediterranean fever
MICA MHC class I polypeptide-related sequence A
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
NLRP3 NLR family, pyrin domain containing 3
PARP1 poly (ADP-ribose) polymerase 1
PYCARD PYD and CARD domain containing
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SOD2 superoxide dismutase 2, mitochondrial
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TIMP1 TIMP metallopeptidase inhibitor 1
TNF tumor necrosis factor
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TPMT thiopurine S-methyltransferase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor