arthritis, rheumatoid; rheumatoid arthritis Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description disease cluster belonging to disease group immune (Genetic Association Database)
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Genes

176 genes associated with the disease arthritis, rheumatoid; rheumatoid arthritis in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ADA adenosine deaminase
ADAD1 adenosine deaminase domain containing 1 (testis-specific)
ADRB2 adrenoceptor beta 2, surface
AFF3 AF4/FMR2 family, member 3
ANKRD55 ankyrin repeat domain 55
AR androgen receptor
C5 complement component 5
C9ORF72 chromosome 9 open reading frame 72
CCL21 chemokine (C-C motif) ligand 21
CCL3 chemokine (C-C motif) ligand 3
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CD226 CD226 molecule
CD28 CD28 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD58 CD58 molecule
CD99 CD99 molecule
CDH13 cadherin 13
CDK6 cyclin-dependent kinase 6
CEP72 centrosomal protein 72kDa
CRP C-reactive protein, pentraxin-related
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
DHFR dihydrofolate reductase
DUSP1 dual specificity phosphatase 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ESR2 estrogen receptor 2 (ER beta)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FCRL3 Fc receptor-like 3
FLG filaggrin
GBP6 guanylate binding protein family, member 6
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GHSR growth hormone secretagogue receptor
GIN1 gypsy retrotransposon integrase 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTRA1 HtrA serine peptidase 1
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
IL10 interleukin 10
IL17A interleukin 17A
IL17F interleukin 17F
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1F10 interleukin 1 family, member 10 (theta)
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL23R interleukin 23 receptor
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL36A interleukin 36, alpha
IL36B interleukin 36, beta
IL36G interleukin 36, gamma
IL36RN interleukin 36 receptor antagonist
IL37 interleukin 37
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IL9R interleukin 9 receptor
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRAK1 interleukin-1 receptor-associated kinase 1
IRF5 interferon regulatory factor 5
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
KIAA1109 KIAA1109
KIF5A kinesin family member 5A
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
LTA lymphotoxin alpha
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K6 mitogen-activated protein kinase kinase 6
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MEFV Mediterranean fever
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR146A microRNA 146a
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMEL1 membrane metallo-endopeptidase-like 1
MMP3 matrix metallopeptidase 3
MOB3B MOB kinase activator 3B
MPG N-methylpurine-DNA glycosylase
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MYO3A myosin IIIA
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOD2 nucleotide-binding oligomerization domain containing 2
NPSR1 neuropeptide S receptor 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NREP neuronal regeneration related protein
OLIG3 oligodendrocyte transcription factor 3
PADI4 peptidyl arginine deiminase, type IV
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRDM1 PR domain containing 1, with ZNF domain
PRKCQ protein kinase C, theta
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
PXK PX domain containing serine/threonine kinase
RBPJ recombination signal binding protein for immunoglobulin kappa J region
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RFC1 replication factor C (activator 1) 1, 145kDa
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RPS12P4 ribosomal protein S12 pseudogene 4
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SFTPD surfactant protein D
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SPRED2 sprouty-related, EVH1 domain containing 2
STAT4 signal transducer and activator of transcription 4
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAGAP T-cell activation RhoGTPase activating protein
TF transferrin
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53
TRAF1 TNF receptor-associated factor 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TYMS thymidylate synthetase
UBA1 ubiquitin-like modifier activating enzyme 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WFDC1 WAP four-disulfide core domain 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1