arcaine-4974 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the arcaine-4974 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APOM apolipoprotein M
AQP3 aquaporin 3 (Gill blood group)
ARHGAP44 Rho GTPase activating protein 44
ARNT aryl hydrocarbon receptor nuclear translocator
ARTN artemin
AUTS2 autism susceptibility candidate 2
BAZ2A bromodomain adjacent to zinc finger domain, 2A
CAPN9 calpain 9
CCDC85C coiled-coil domain containing 85C
CCNO cyclin O
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD36 CD36 molecule (thrombospondin receptor)
CD6 CD6 molecule
CD82 CD82 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CENPO centromere protein O
CLCN7 chloride channel, voltage-sensitive 7
CNTN1 contactin 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCR4 chemokine (C-X-C motif) receptor 4
DHRS12 dehydrogenase/reductase (SDR family) member 12
DMPK dystrophia myotonica-protein kinase
DTX2 deltex 2, E3 ubiquitin ligase
EML2 echinoderm microtubule associated protein like 2
EPHA1 EPH receptor A1
FAM134B family with sequence similarity 134, member B
FBXO41 F-box protein 41
FGD1 FYVE, RhoGEF and PH domain containing 1
GAMT guanidinoacetate N-methyltransferase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR137 G protein-coupled receptor 137
GPR27 G protein-coupled receptor 27
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HEATR1 HEAT repeat containing 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIRA histone cell cycle regulator
HMOX1 heme oxygenase 1
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOMER3 homer scaffolding protein 3
HOXB2 homeobox B2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ING2 inhibitor of growth family, member 2
ING4 inhibitor of growth family, member 4
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KHSRP KH-type splicing regulatory protein
KIAA0319L KIAA0319-like
KIAA0368 KIAA0368
LENEP lens epithelial protein
MARK4 MAP/microtubule affinity-regulating kinase 4
MINK1 misshapen-like kinase 1
MMP3 matrix metallopeptidase 3
MTM1 myotubularin 1
MUC3A mucin 3A, cell surface associated
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NF2 neurofibromin 2 (merlin)
OSGIN1 oxidative stress induced growth inhibitor 1
PAPOLA poly(A) polymerase alpha
PDE3B phosphodiesterase 3B, cGMP-inhibited
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
POMT2 protein-O-mannosyltransferase 2
POU4F2 POU class 4 homeobox 2
PROL1 proline rich, lacrimal 1
QTRT1 queuine tRNA-ribosyltransferase 1
RAD23B RAD23 homolog B (S. cerevisiae)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RARG retinoic acid receptor, gamma
RBM19 RNA binding motif protein 19
RPLP2 ribosomal protein, large, P2
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SAYSD1 SAYSVFN motif domain containing 1
SEC14L5 SEC14-like 5 (S. cerevisiae)
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SIRT3 sirtuin 3
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMG7 SMG7 nonsense mediated mRNA decay factor
SNTA1 syntrophin, alpha 1
SPHK2 sphingosine kinase 2
STON1 stonin 1
SULT4A1 sulfotransferase family 4A, member 1
TLE3 transducin-like enhancer of split 3
TLR5 toll-like receptor 5
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRIO trio Rho guanine nucleotide exchange factor
TUBA4B tubulin, alpha 4b
UBE2B ubiquitin-conjugating enzyme E2B
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WSB1 WD repeat and SOCS box containing 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZER1 zyg-11 related, cell cycle regulator
ZFHX4 zinc finger homeobox 4
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF493 zinc finger protein 493

decreased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL15 ADP-ribosylation factor-like 15
BAHD1 bromo adjacent homology domain containing 1
BCL2A1 BCL2-related protein A1
BIRC3 baculoviral IAP repeat containing 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
C11ORF80 chromosome 11 open reading frame 80
C19ORF73 chromosome 19 open reading frame 73
C5AR2 complement component 5a receptor 2
CA11 carbonic anhydrase XI
CA5BP1 carbonic anhydrase VB pseudogene 1
CASZ1 castor zinc finger 1
CCDC132 coiled-coil domain containing 132
CD34 CD34 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CHPF chondroitin polymerizing factor
CLSTN2 calsyntenin 2
CRIP1 cysteine-rich protein 1 (intestinal)
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DVL1 dishevelled segment polarity protein 1
DYSF dysferlin
ERN2 endoplasmic reticulum to nucleus signaling 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM155A family with sequence similarity 155, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXL6 F-box and leucine-rich repeat protein 6
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FILIP1L filamin A interacting protein 1-like
FOXN2 forkhead box N2
FRK fyn-related Src family tyrosine kinase
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GDAP2 ganglioside induced differentiation associated protein 2
GEM GTP binding protein overexpressed in skeletal muscle
GID4 GID complex subunit 4
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GOLGA8B golgin A8 family, member B
GPR157 G protein-coupled receptor 157
HAMP hepcidin antimicrobial peptide
HIST1H2AL histone cluster 1, H2al
HIST1H2BO histone cluster 1, H2bo
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA5 homeobox A5
HOXC5 homeobox C5
HP1BP3 heterochromatin protein 1, binding protein 3
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFI27 interferon, alpha-inducible protein 27
IRF2BP1 interferon regulatory factor 2 binding protein 1
KIAA0754 KIAA0754
LRP2 low density lipoprotein receptor-related protein 2
MAPKBP1 mitogen-activated protein kinase binding protein 1
MCTP1 multiple C2 domains, transmembrane 1
MRPL41 mitochondrial ribosomal protein L41
MVP major vault protein
MYF5 myogenic factor 5
NES nestin
PAQR4 progestin and adipoQ receptor family member IV
PDE8B phosphodiesterase 8B
PITX2 paired-like homeodomain 2
PLCD1 phospholipase C, delta 1
POLL polymerase (DNA directed), lambda
POM121 POM121 transmembrane nucleoporin
PRPH peripherin
RAB30 RAB30, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RNF39 ring finger protein 39
RPAP1 RNA polymerase II associated protein 1
SAMD9 sterile alpha motif domain containing 9
SCN1B sodium channel, voltage gated, type I beta subunit
SKI SKI proto-oncogene
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TBC1D19 TBC1 domain family, member 19
TCTA T-cell leukemia translocation altered
TESC tescalcin
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TH tyrosine hydroxylase
TIGD6 tigger transposable element derived 6
TMC5 transmembrane channel-like 5
TMEM121 transmembrane protein 121
TMEM212 transmembrane protein 212
TOM1 target of myb1 (chicken)
TRAIP TRAF interacting protein
TRIM21 tripartite motif containing 21
TUBA3C tubulin, alpha 3c
UBXN6 UBX domain protein 6
UNC119 unc-119 homolog (C. elegans)
VEGFC vascular endothelial growth factor C
ZNF10 zinc finger protein 10
ZNF16 zinc finger protein 16
ZNF304 zinc finger protein 304
ZNF516 zinc finger protein 516
ZNF551 zinc finger protein 551
ZNF571 zinc finger protein 571
ZNF639 zinc finger protein 639
ZNF747 zinc finger protein 747