apramycin-7334 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the apramycin-7334 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ADRBK2 adrenergic, beta, receptor kinase 2
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARSB arylsulfatase B
ATG3 autophagy related 3
ATP9A ATPase, class II, type 9A
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COX4I1 cytochrome c oxidase subunit IV isoform 1
CPN2 carboxypeptidase N, polypeptide 2
CSF1R colony stimulating factor 1 receptor
DCBLD2 discoidin, CUB and LCCL domain containing 2
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOC2A double C2-like domains, alpha
EFCAB11 EF-hand calcium binding domain 11
EFNA3 ephrin-A3
EHD2 EH-domain containing 2
EXO5 exonuclease 5
F3 coagulation factor III (thromboplastin, tissue factor)
FAM120C family with sequence similarity 120C
FAM65A family with sequence similarity 65, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FSCN1 fascin actin-bundling protein 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GJA8 gap junction protein, alpha 8, 50kDa
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HBS1L HBS1-like translational GTPase
HIC2 hypermethylated in cancer 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXC8 homeobox C8
IGL immunoglobulin lambda locus
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIF13A kinesin family member 13A
KLHL20 kelch-like family member 20
LAMP1 lysosomal-associated membrane protein 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOC390998 ribosomal protein L10 pseudogene
LPCAT4 lysophosphatidylcholine acyltransferase 4
LPPR1 lipid phosphate phosphatase-related protein type 1
MAMLD1 mastermind-like domain containing 1
MID1 midline 1
MIIP migration and invasion inhibitory protein
MUC1 mucin 1, cell surface associated
NCKAP1 NCK-associated protein 1
NDOR1 NADPH dependent diflavin oxidoreductase 1
NF1 neurofibromin 1
PADI1 peptidyl arginine deiminase, type I
PDE8B phosphodiesterase 8B
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PDLIM7 PDZ and LIM domain 7 (enigma)
PML promyelocytic leukemia
PRKG2 protein kinase, cGMP-dependent, type II
PTK6 protein tyrosine kinase 6
PXN paxillin
RAD54L2 RAD54-like 2 (S. cerevisiae)
RECQL5 RecQ protein-like 5
RGS12 regulator of G-protein signaling 12
RHOBTB2 Rho-related BTB domain containing 2
RIF1 replication timing regulatory factor 1
RNF126P1 ring finger protein 126 pseudogene 1
RPL13P5 ribosomal protein L13 pseudogene 5
SCN10A sodium channel, voltage gated, type X alpha subunit
SEC24D SEC24 family member D
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SENP6 SUMO1/sentrin specific peptidase 6
SERHL2 serine hydrolase-like 2
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SH3BP2 SH3-domain binding protein 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SUN1 Sad1 and UNC84 domain containing 1
TBKBP1 TBK1 binding protein 1
TOP3A topoisomerase (DNA) III alpha
TOP3B topoisomerase (DNA) III beta
TRIB2 tribbles pseudokinase 2
TRIM3 tripartite motif containing 3
TSPAN9 tetraspanin 9
TTC33 tetratricopeptide repeat domain 33
UBXN6 UBX domain protein 6
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAC14 Vac14 homolog (S. cerevisiae)
VDAC3 voltage-dependent anion channel 3
VEGFA vascular endothelial growth factor A
VN1R1 vomeronasal 1 receptor 1
YY2 YY2 transcription factor
ZC3H7B zinc finger CCCH-type containing 7B
ZFHX4 zinc finger homeobox 4
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF442 zinc finger protein 442
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA2P3 annexin A2 pseudogene 3
ATP7B ATPase, Cu++ transporting, beta polypeptide
BCORL1 BCL6 corepressor-like 1
C1ORF35 chromosome 1 open reading frame 35
C22ORF29 chromosome 22 open reading frame 29
C2ORF54 chromosome 2 open reading frame 54
CAPN15 calpain 15
CCDC176 coiled-coil domain containing 176
CCDC88C coiled-coil domain containing 88C
CCNL2 cyclin L2
CDKL3 cyclin-dependent kinase-like 3
CIDEC cell death-inducing DFFA-like effector c
COPS7B COP9 signalosome subunit 7B
CTAGE9 CTAGE family, member 9
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DEAF1 DEAF1 transcription factor
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
EAF2 ELL associated factor 2
ENO2 enolase 2 (gamma, neuronal)
FKBP10 FK506 binding protein 10, 65 kDa
FURIN furin (paired basic amino acid cleaving enzyme)
FUZ fuzzy planar cell polarity protein
FYCO1 FYVE and coiled-coil domain containing 1
GLS2 glutaminase 2 (liver, mitochondrial)
GPATCH2L G patch domain containing 2-like
GPC3 glypican 3
GPR27 G protein-coupled receptor 27
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HIST1H4F histone cluster 1, H4f
HIST2H2AA3 histone cluster 2, H2aa3
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IFI6 interferon, alpha-inducible protein 6
IRF1 interferon regulatory factor 1
ITPKB inositol-trisphosphate 3-kinase B
KCTD15 potassium channel tetramerization domain containing 15
KIAA0556 KIAA0556
KIF13B kinesin family member 13B
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL12 kelch-like family member 12
KREMEN2 kringle containing transmembrane protein 2
LAMB3 laminin, beta 3
LMO2 LIM domain only 2 (rhombotin-like 1)
MATK megakaryocyte-associated tyrosine kinase
MBTD1 mbt domain containing 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED4 mediator complex subunit 4
MID1IP1 MID1 interacting protein 1
NRSN2 neurensin 2
NT5C 5', 3'-nucleotidase, cytosolic
NT5DC3 5'-nucleotidase domain containing 3
OLFML2A olfactomedin-like 2A
OTUD3 OTU deubiquitinase 3
PCDHB3 protocadherin beta 3
PCDHB8 protocadherin beta 8
PDLIM2 PDZ and LIM domain 2 (mystique)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PODXL2 podocalyxin-like 2
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIBC2 RIB43A domain with coiled-coils 2
RNF170 ring finger protein 170
RNF25 ring finger protein 25
RNF31 ring finger protein 31
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SCN1B sodium channel, voltage gated, type I beta subunit
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC12A8 solute carrier family 12, member 8
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPIDR scaffolding protein involved in DNA repair
STARD13 StAR-related lipid transfer (START) domain containing 13
STX1A syntaxin 1A (brain)
SYT17 synaptotagmin XVII
TAOK1 TAO kinase 1
TMCC2 transmembrane and coiled-coil domain family 2
TNRC6B trinucleotide repeat containing 6B
TRAF2 TNF receptor-associated factor 2
TRAIP TRAF interacting protein
TSPYL2 TSPY-like 2
TUBA3C tubulin, alpha 3c
TWF2 twinfilin actin binding protein 2
USP27X ubiquitin specific peptidase 27, X-linked
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WWC2 WW and C2 domain containing 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF227 zinc finger protein 227
ZNF276 zinc finger protein 276
ZNF580 zinc finger protein 580
ZNF747 zinc finger protein 747
ZNF816 zinc finger protein 816