apramycin-2914 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the apramycin-2914 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADARB1 adenosine deaminase, RNA-specific, B1
ADTRP androgen-dependent TFPI-regulating protein
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOE apolipoprotein E
ATP13A2 ATPase type 13A2
C1ORF105 chromosome 1 open reading frame 105
CCL21 chemokine (C-C motif) ligand 21
CCL22 chemokine (C-C motif) ligand 22
CCR9 chemokine (C-C motif) receptor 9
CD59 CD59 molecule, complement regulatory protein
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CECR1 cat eye syndrome chromosome region, candidate 1
CES3 carboxylesterase 3
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLCF1 cardiotrophin-like cytokine factor 1
CLEC4A C-type lectin domain family 4, member A
COL2A1 collagen, type II, alpha 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CREM cAMP responsive element modulator
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTSZ cathepsin Z
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DNAAF1 dynein, axonemal, assembly factor 1
EPYC epiphycan
EXTL3 exostosin-like glycosyltransferase 3
F12 coagulation factor XII (Hageman factor)
FAM169A family with sequence similarity 169, member A
FBXO22 F-box protein 22
FGD1 FYVE, RhoGEF and PH domain containing 1
FGFR2 fibroblast growth factor receptor 2
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GIPC1 GIPC PDZ domain containing family, member 1
GPATCH4 G patch domain containing 4
HFE hemochromatosis
HLA-DMB major histocompatibility complex, class II, DM beta
HRASLS2 HRAS-like suppressor 2
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
IFNA17 interferon, alpha 17
ING2 inhibitor of growth family, member 2
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LOC390998 ribosomal protein L10 pseudogene
LRRC20 leucine rich repeat containing 20
MAGEH1 melanoma antigen family H1
MB myoglobin
MEFV Mediterranean fever
MET MET proto-oncogene, receptor tyrosine kinase
MUC3A mucin 3A, cell surface associated
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NCALD neurocalcin delta
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLE1 notchless homolog 1 (Drosophila)
NLRP1 NLR family, pyrin domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NPFFR1 neuropeptide FF receptor 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OGFR opioid growth factor receptor
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PLBD1 phospholipase B domain containing 1
PML promyelocytic leukemia
POFUT2 protein O-fucosyltransferase 2
PSG9 pregnancy specific beta-1-glycoprotein 9
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
REC8 REC8 meiotic recombination protein
RECQL5 RecQ protein-like 5
RGS5 regulator of G-protein signaling 5
RHCG Rh family, C glycoprotein
RNF39 ring finger protein 39
RRBP1 ribosome binding protein 1
RUNX1 runt-related transcription factor 1
SH3PXD2A SH3 and PX domains 2A
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLCO2B1 solute carrier organic anion transporter family, member 2B1
STAT2 signal transducer and activator of transcription 2, 113kDa
STOM stomatin
SULT4A1 sulfotransferase family 4A, member 1
TBKBP1 TBK1 binding protein 1
TCL1A T-cell leukemia/lymphoma 1A
TRBC1 T cell receptor beta constant 1
TRIM10 tripartite motif containing 10
TRIM62 tripartite motif containing 62
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TTC30A tetratricopeptide repeat domain 30A
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WDTC1 WD and tetratricopeptide repeats 1
XDH xanthine dehydrogenase

decreased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
BAMBI BMP and activin membrane-bound inhibitor
C1ORF21 chromosome 1 open reading frame 21
C5 complement component 5
CARF calcium responsive transcription factor
CENPT centromere protein T
CEP295 centrosomal protein 295kDa
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
DNAL4 dynein, axonemal, light chain 4
DPY19L2P2 DPY19L2 pseudogene 2
DTWD1 DTW domain containing 1
DUSP2 dual specificity phosphatase 2
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ECI1 enoyl-CoA delta isomerase 1
ELP6 elongator acetyltransferase complex subunit 6
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV4 ets variant 4
F3 coagulation factor III (thromboplastin, tissue factor)
FAM204A family with sequence similarity 204, member A
FANCF Fanconi anemia, complementation group F
FBXL15 F-box and leucine-rich repeat protein 15
FES FES proto-oncogene, tyrosine kinase
GEM GTP binding protein overexpressed in skeletal muscle
GPATCH2 G patch domain containing 2
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GUSBP3 glucuronidase, beta pseudogene 3
HIPK2 homeodomain interacting protein kinase 2
HOMER1 homer scaffolding protein 1
ICK intestinal cell (MAK-like) kinase
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IMPAD1 inositol monophosphatase domain containing 1
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IPO8 importin 8
ITGAV integrin, alpha V
LIMD2 LIM domain containing 2
LIN37 lin-37 DREAM MuvB core complex component
LINS lines homolog (Drosophila)
LOC157562 uncharacterized LOC157562
LRRC42 leucine rich repeat containing 42
LRRK1 leucine-rich repeat kinase 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP1S microtubule-associated protein 1S
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MATK megakaryocyte-associated tyrosine kinase
MGC12488
MICALL2 MICAL-like 2
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
MX1 MX dynamin-like GTPase 1
MYBBP1A MYB binding protein (P160) 1a
NRBP1 nuclear receptor binding protein 1
NTSR1 neurotensin receptor 1 (high affinity)
PEX26 peroxisomal biogenesis factor 26
PHACTR4 phosphatase and actin regulator 4
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PISD phosphatidylserine decarboxylase
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
PNRC1 proline-rich nuclear receptor coactivator 1
PPIEL peptidylprolyl isomerase E-like pseudogene
PTDSS2 phosphatidylserine synthase 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF123 ring finger protein 123
RNF126P1 ring finger protein 126 pseudogene 1
RPAP1 RNA polymerase II associated protein 1
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCAP SREBF chaperone
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH2B2 SH2B adaptor protein 2
SH2D3C SH2 domain containing 3C
SLC10A3 solute carrier family 10, member 3
SLC12A9 solute carrier family 12, member 9
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SP140L SP140 nuclear body protein-like
SPAG1 sperm associated antigen 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STK25 serine/threonine kinase 25
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEP1 telomerase-associated protein 1
TESK1 testis-specific kinase 1
TGM5 transglutaminase 5
THBS3 thrombospondin 3
THOP1 thimet oligopeptidase 1
TRAPPC11 trafficking protein particle complex 11
TUBB2A tubulin, beta 2A class IIa
VCPKMT valosin containing protein lysine (K) methyltransferase
YIPF1 Yip1 domain family, member 1
ZDHHC18 zinc finger, DHHC-type containing 18
ZMAT5 zinc finger, matrin-type 5
ZNF215 zinc finger protein 215
ZNF354A zinc finger protein 354A
ZNF432 zinc finger protein 432
ZNF493 zinc finger protein 493