apoptotic signaling pathway Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. (Gene Ontology, GO_0097190)
External Link http://amigo.geneontology.org/amigo/term/GO:0097190
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Genes

326 genes participating in the apoptotic signaling pathway biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABR active BCR-related
ACVR1B activin A receptor, type IB
ADAM17 ADAM metallopeptidase domain 17
ADORA1 adenosine A1 receptor
AEN apoptosis enhancing nuclease
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKAP13 A kinase (PRKA) anchor protein 13
AKT1 v-akt murine thymoma viral oncogene homolog 1
APAF1 apoptotic peptidase activating factor 1
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
APOPT1 apoptogenic 1, mitochondrial
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARHGAP4 Rho GTPase activating protein 4
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF4 activating transcription factor 4
ATM ATM serine/threonine kinase
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
BAD BCL2-associated agonist of cell death
BAG3 BCL2-associated athanogene 3
BAG6 BCL2-associated athanogene 6
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L2 BCL2-like 2
BCL3 B-cell CLL/lymphoma 3
BID BH3 interacting domain death agonist
BLOC1S2 biogenesis of lysosomal organelles complex-1, subunit 2
BMF Bcl2 modifying factor
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BOK BCL2-related ovarian killer
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRSK2 BR serine/threonine kinase 2
BTK Bruton agammaglobulinemia tyrosine kinase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP12 caspase 12 (gene/pseudogene)
CASP14 caspase 14, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP8AP2 caspase 8 associated protein 2
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CD27 CD27 molecule
CD28 CD28 molecule
CD38 CD38 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD5 CD5 molecule
CD70 CD70 molecule
CDIP1 cell death-inducing p53 target 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHEK2 checkpoint kinase 2
CIB1 calcium and integrin binding 1 (calmyrin)
CIDEB cell death-inducing DFFA-like effector b
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRH corticotropin releasing hormone
CRIP1 cysteine-rich protein 1 (intestinal)
CUL1 cullin 1
CUL2 cullin 2
CUL3 cullin 3
CUL4A cullin 4A
CUL5 cullin 5
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2IP DAB2 interacting protein
DAP death-associated protein
DAP3 death associated protein 3
DAPK1 death-associated protein kinase 1
DAPK3 death-associated protein kinase 3
DAXX death-domain associated protein
DCC DCC netrin 1 receptor
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DEDD death effector domain containing
DEDD2 death effector domain containing 2
DIABLO diablo, IAP-binding mitochondrial protein
DIDO1 death inducer-obliterator 1
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DPF2 D4, zinc and double PHD fingers family 2
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
ECT2 epithelial cell transforming 2
EDA2R ectodysplasin A2 receptor
EI24 etoposide induced 2.4
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EP300 E1A binding protein p300
EPHA2 EPH receptor A2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERCC6 excision repair cross-complementation group 6
ERN1 endoplasmic reticulum to nucleus signaling 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1L ERO1-like (S. cerevisiae)
ESR2 estrogen receptor 2 (ER beta)
EYA2 EYA transcriptional coactivator and phosphatase 2
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FASTK Fas-activated serine/threonine kinase
FGD1 FYVE, RhoGEF and PH domain containing 1
FGD2 FYVE, RhoGEF and PH domain containing 2
FGD3 FYVE, RhoGEF and PH domain containing 3
FGD4 FYVE, RhoGEF and PH domain containing 4
FGFR3 fibroblast growth factor receptor 3
FHIT fragile histidine triad
FNIP2 folliculin interacting protein 2
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GABARAP GABA(A) receptor-associated protein
GPX1 glutathione peroxidase 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HIC1 hypermethylated in cancer 1
HINT1 histidine triad nucleotide binding protein 1
HIP1 huntingtin interacting protein 1
HIPK1 homeodomain interacting protein kinase 1
HIPK2 homeodomain interacting protein kinase 2
HMOX1 heme oxygenase 1
HRAS Harvey rat sarcoma viral oncogene homolog
HTRA2 HtrA serine peptidase 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL12A interleukin 12A
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL2 interleukin 2
IL33 interleukin 33
IL4 interleukin 4
IL6R interleukin 6 receptor
INHBA inhibin, beta A
ITGAV integrin, alpha V
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
ITM2B integral membrane protein 2B
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITSN1 intersectin 1 (SH3 domain protein)
JAK2 Janus kinase 2
JMY junction mediating and regulatory protein, p53 cofactor
KALRN kalirin, RhoGEF kinase
KIAA0141 KIAA0141
KITLG KIT ligand
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LAMP1 lysosomal-associated membrane protein 1
LCN2 lipocalin 2
LGALS12 lectin, galactoside-binding, soluble, 12
MAEL maelstrom spermatogenic transposon silencer
MAGED1 melanoma antigen family D1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK8 mitogen-activated protein kinase 8
MBD4 methyl-CpG binding domain protein 4
MCF2 MCF.2 cell line derived transforming sequence
MCF2L MCF.2 cell line derived transforming sequence-like
MCL1 myeloid cell leukemia 1
MELK maternal embryonic leucine zipper kinase
MKNK1 MAP kinase interacting serine/threonine kinase 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLH1 mutL homolog 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOAP1 modulator of apoptosis 1
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MYBBP1A MYB binding protein (P160) 1a
NBN nibrin
NCSTN nicastrin
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NET1 neuroepithelial cell transforming 1
NF1 neurofibromin 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NGEF neuronal guanine nucleotide exchange factor
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NMT1 N-myristoyltransferase 1
NUPR1 nuclear protein, transcriptional regulator, 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PARP2 poly (ADP-ribose) polymerase 2
PAWR PRKC, apoptosis, WT1, regulator
PDCD10 programmed cell death 10
PDCD6 programmed cell death 6
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PERP PERP, TP53 apoptosis effector
PGAP2 post-GPI attachment to proteins 2
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PML promyelocytic leukemia
POLB polymerase (DNA directed), beta
PPARD peroxisome proliferator-activated receptor delta
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRODH proline dehydrogenase (oxidase) 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
PTGIS prostaglandin I2 (prostacyclin) synthase
PTH parathyroid hormone
PYCARD PYD and CARD domain containing
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK3 receptor-interacting serine-threonine kinase 3
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RNF7 ring finger protein 7
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS27A ribosomal protein S27a
RPS27L ribosomal protein S27-like
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SART1 squamous cell carcinoma antigen recognized by T cells
SCN2A sodium channel, voltage gated, type II alpha subunit
SELK selenoprotein K
SENP1 SUMO1/sentrin specific peptidase 1
SFN stratifin
SGPL1 sphingosine-1-phosphate lyase 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SHH sonic hedgehog
SHISA5 shisa family member 5
SIRT1 sirtuin 1
SIVA1 SIVA1, apoptosis-inducing factor
SMAD3 SMAD family member 3
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNW1 SNW domain containing 1
SOD2 superoxide dismutase 2, mitochondrial
SORT1 sortilin 1
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SQSTM1 sequestosome 1
SRGN serglycin
SST somatostatin
SSTR3 somatostatin receptor 3
ST20 suppressor of tumorigenicity 20
STK11 serine/threonine kinase 11
STK24 serine/threonine kinase 24
STK25 serine/threonine kinase 25
TFDP1 transcription factor Dp-1
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TICAM1 toll-like receptor adaptor molecule 1
TLR3 toll-like receptor 3
TM2D1 TM2 domain containing 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM109 transmembrane protein 109
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TP73 tumor protein p73
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIB3 tribbles pseudokinase 3
TRIO trio Rho guanine nucleotide exchange factor
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2K ubiquitin-conjugating enzyme E2K
UBE4B ubiquitination factor E4B
UNC5A unc-5 homolog A (C. elegans)
UNC5B unc-5 homolog B (C. elegans)
USP28 ubiquitin specific peptidase 28
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
WWOX WW domain containing oxidoreductase
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPA xeroderma pigmentosum, complementation group A
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF385B zinc finger protein 385B
ZNF622 zinc finger protein 622