apigenin-4401 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the apigenin-4401 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AHSP alpha hemoglobin stabilizing protein
ALDH8A1 aldehyde dehydrogenase 8 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANGPTL2 angiopoietin-like 2
APOLD1 apolipoprotein L domain containing 1
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ASCL1 achaete-scute family bHLH transcription factor 1
ASIC1 acid sensing (proton gated) ion channel 1
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAP29 B-cell receptor-associated protein 29
C4BPB complement component 4 binding protein, beta
C8ORF44 chromosome 8 open reading frame 44
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CATSPERB catsper channel auxiliary subunit beta
CCDC106 coiled-coil domain containing 106
CCDC132 coiled-coil domain containing 132
CCL21 chemokine (C-C motif) ligand 21
CD84 CD84 molecule
CDKL3 cyclin-dependent kinase-like 3
CEL carboxyl ester lipase
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC4A C-type lectin domain family 4, member A
COPE coatomer protein complex, subunit epsilon
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CST4 cystatin S
CTSZ cathepsin Z
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAPK1 death-associated protein kinase 1
DGCR8 DGCR8 microprocessor complex subunit
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
EDN1 endothelin 1
EGR1 early growth response 1
EGR3 early growth response 3
EGR4 early growth response 4
FBLN1 fibulin 1
FETUB fetuin B
FKBP6 FK506 binding protein 6, 36kDa
FRMD1 FERM domain containing 1
FRZB frizzled-related protein
GGT1 gamma-glutamyltransferase 1
GLS glutaminase
GPATCH2L G patch domain containing 2-like
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H2AL histone cluster 1, H2al
HIST1H3B histone cluster 1, H3b
HOXD11 homeobox D11
HRH1 histamine receptor H1
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
IFFO1 intermediate filament family orphan 1
IGF1R insulin-like growth factor 1 receptor
IL21 interleukin 21
IRF4 interferon regulatory factor 4
KALRN kalirin, RhoGEF kinase
KCTD13 potassium channel tetramerization domain containing 13
KIAA1024 KIAA1024
LCAT lecithin-cholesterol acyltransferase
LMAN1 lectin, mannose-binding, 1
LOC100131510 uncharacterized LOC100131510
LOC157562 uncharacterized LOC157562
MALL mal, T-cell differentiation protein-like
MED25 mediator complex subunit 25
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
MTL5 metallothionein-like 5, testis-specific (tesmin)
MUC8 mucin 8
NPY neuropeptide Y
PAPPA2 pappalysin 2
PCDHB1 protocadherin beta 1
PDLIM3 PDZ and LIM domain 3
PLD1 phospholipase D1, phosphatidylcholine-specific
PPARD peroxisome proliferator-activated receptor delta
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PSAT1 phosphoserine aminotransferase 1
RAB14 RAB14, member RAS oncogene family
RPL10L ribosomal protein L10-like
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SAMD4A sterile alpha motif domain containing 4A
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SIRT4 sirtuin 4
SKAP1 src kinase associated phosphoprotein 1
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SPRED2 sprouty-related, EVH1 domain containing 2
SSX3 synovial sarcoma, X breakpoint 3
STAB1 stabilin 1
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TESPA1 thymocyte expressed, positive selection associated 1
TRBC1 T cell receptor beta constant 1
TSC2 tuberous sclerosis 2
UCN urocortin
USP36 ubiquitin specific peptidase 36
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZNF606 zinc finger protein 606
ZRSR1 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADCY7 adenylate cyclase 7
ADORA2B adenosine A2b receptor
AFAP1 actin filament associated protein 1
AKAP12 A kinase (PRKA) anchor protein 12
ARMCX5 armadillo repeat containing, X-linked 5
BAHCC1 BAH domain and coiled-coil containing 1
BBS7 Bardet-Biedl syndrome 7
BEX4 brain expressed, X-linked 4
BFSP1 beaded filament structural protein 1, filensin
BMP4 bone morphogenetic protein 4
C12ORF4 chromosome 12 open reading frame 4
C2CD2 C2 calcium-dependent domain containing 2
C9ORF3 chromosome 9 open reading frame 3
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CBX8 chromobox homolog 8
CCP110 centriolar coiled coil protein 110kDa
CDC73 cell division cycle 73
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DTX2 deltex 2, E3 ubiquitin ligase
EAF2 ELL associated factor 2
ETV6 ets variant 6
F3 coagulation factor III (thromboplastin, tissue factor)
FBXL2 F-box and leucine-rich repeat protein 2
FGF13 fibroblast growth factor 13
GPRC5C G protein-coupled receptor, class C, group 5, member C
GRAMD1C GRAM domain containing 1C
HHEX hematopoietically expressed homeobox
HOXC13 homeobox C13
HSPA2 heat shock 70kDa protein 2
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
ICK intestinal cell (MAK-like) kinase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IRF9 interferon regulatory factor 9
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KLF11 Kruppel-like factor 11
LIN7A lin-7 homolog A (C. elegans)
LOC257152 uncharacterized LOC257152
LOC730101 uncharacterized LOC730101
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MMP9 matrix metallopeptidase 9
N4BP3 NEDD4 binding protein 3
NXPE3 neurexophilin and PC-esterase domain family, member 3
OASL 2'-5'-oligoadenylate synthetase-like
PAIP2B poly(A) binding protein interacting protein 2B
PAQR3 progestin and adipoQ receptor family member III
PARP12 poly (ADP-ribose) polymerase family, member 12
PCDHB3 protocadherin beta 3
PCTP phosphatidylcholine transfer protein
PLCD1 phospholipase C, delta 1
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PMP22 peripheral myelin protein 22
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRSS16 protease, serine, 16 (thymus)
RFTN1 raftlin, lipid raft linker 1
RHOBTB2 Rho-related BTB domain containing 2
S100A9 S100 calcium binding protein A9
SCAI suppressor of cancer cell invasion
SLC22A14 solute carrier family 22, member 14
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLIT2 slit homolog 2 (Drosophila)
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNTA1 syntrophin, alpha 1
SPC25 SPC25, NDC80 kinetochore complex component
SPINK5 serine peptidase inhibitor, Kazal type 5
SRD5A3 steroid 5 alpha-reductase 3
SSBP3 single stranded DNA binding protein 3
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TARP TCR gamma alternate reading frame protein
TRIM21 tripartite motif containing 21
TRIM45 tripartite motif containing 45
TRIM5 tripartite motif containing 5
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
TTC17 tetratricopeptide repeat domain 17
USP19 ubiquitin specific peptidase 19
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VGF VGF nerve growth factor inducible
VIPR1 vasoactive intestinal peptide receptor 1
XYLT2 xylosyltransferase II
ZFP69B ZFP69 zinc finger protein B
ZFYVE16 zinc finger, FYVE domain containing 16
ZIC1 Zic family member 1
ZNF10 zinc finger protein 10