anxiety disorder Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A cognitive disorder that involves an excessive, irrational dread of everyday situations. (Human Disease Ontology, DOID_2030)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:2030
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Genes

360 genes associated with the disease anxiety disorder in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
SYT1 synaptotagmin I 1.47287
BICD1 bicaudal D homolog 1 (Drosophila) 1.42581
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 1.38231
UGDH UDP-glucose 6-dehydrogenase 1.3316
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 1.32976
GPC6 glypican 6 1.31635
NKAIN2 Na+/K+ transporting ATPase interacting 2 1.26953
LIAS lipoic acid synthetase 1.24752
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 1.21996
RPL9 ribosomal protein L9 1.1764
PDE4D phosphodiesterase 4D, cAMP-specific 1.14463
PTN pleiotrophin 1.0538
FLJ45872 1.02476
NXPH1 neurexophilin 1 1.00407
TMPRSS9 transmembrane protease, serine 9 0.986376
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.952622
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 0.922781
PRICKLE2 prickle homolog 2 (Drosophila) 0.848443
STX8 syntaxin 8 0.818364
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.807706
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.7912
IFIH1 interferon induced with helicase C domain 1 0.773189
AATF apoptosis antagonizing transcription factor 0.76582
SNTG1 syntrophin, gamma 1 0.749605
DSP desmoplakin 0.726413
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.674534
PXDNL peroxidasin-like 0.672258
CNBD1 cyclic nucleotide binding domain containing 1 0.659337
TRIM67 tripartite motif containing 67 0.650844
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.644215
ADAM18 ADAM metallopeptidase domain 18 0.594024
CSMD1 CUB and Sushi multiple domains 1 0.562845
CASS4 Cas scaffolding protein family member 4 0.526189
TCF4 transcription factor 4 0.500542
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 0.460757
GRM7 glutamate receptor, metabotropic 7 0.454009
TLL1 tolloid-like 1 0.449115
ANO2 anoctamin 2, calcium activated chloride channel 0.446617
FHIT fragile histidine triad 0.440544
LRP1B low density lipoprotein receptor-related protein 1B 0.43998
PRDM16 PR domain containing 16 0.439795
SGCZ sarcoglycan, zeta 0.436853
CNTN4 contactin 4 0.432223
COL27A1 collagen, type XXVII, alpha 1 0.428796
TMEM132D transmembrane protein 132D 0.424493
PKP1 plakophilin 1 0.42425
PEPD peptidase D 0.411647
SDK2 sidekick cell adhesion molecule 2 0.410854
CALCOCO1 calcium binding and coiled-coil domain 1 0.406567
PRDM11 PR domain containing 11 0.406451
FAM49B family with sequence similarity 49, member B 0.396759
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.382752
ZMAT3 zinc finger, matrin-type 3 0.382752
NDRG1 N-myc downstream regulated 1 0.376937
LARGE like-glycosyltransferase 0.373922
PRKCA protein kinase C, alpha 0.369654
GRID1 glutamate receptor, ionotropic, delta 1 0.369654
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.369654
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.368492
TLR1 toll-like receptor 1 0.367293
LSMEM1 leucine-rich single-pass membrane protein 1 0.367095
PHEX phosphate regulating endopeptidase homolog, X-linked 0.366972
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 0.366972
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.363868
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 0.360844
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.359545
STON2 stonin 2 0.353873
TMEM132B transmembrane protein 132B 0.350101
ELMO1 engulfment and cell motility 1 0.349431
RGS6 regulator of G-protein signaling 6 0.347436
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 0.346194
RBM23 RNA binding motif protein 23 0.341488
JADE2 jade family PHD finger 2 0.339429
SENP7 SUMO1/sentrin specific peptidase 7 0.338055
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.337406
ANOS1 anosmin 1 0.33652
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial 0.33622
FCRL1 Fc receptor-like 1 0.335883
ARHGEF26-AS1 ARHGEF26 antisense RNA 1 0.335472
ACVR2A activin A receptor, type IIA 0.334639
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 0.33202
WWTR1 WW domain containing transcription regulator 1 0.331691
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.3314
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 0.331113
MBP myelin basic protein 0.330342
STYX serine/threonine/tyrosine interacting protein 0.330043
LOC339298 uncharacterized LOC339298 0.329896
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.329779
DTNA dystrobrevin, alpha 0.329518
CCDC40 coiled-coil domain containing 40 0.329318
TANK TRAF family member-associated NFKB activator 0.329233
MAN2A1 mannosidase, alpha, class 2A, member 1 0.329233
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.328379
MTUS1 microtubule associated tumor suppressor 1 0.328379
PRKD3 protein kinase D3 0.327515
ZFYVE26 zinc finger, FYVE domain containing 26 0.326165
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.325908
PDZRN4 PDZ domain containing ring finger 4 0.325181
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.324617
ARHGAP21 Rho GTPase activating protein 21 0.32449
PREP prolyl endopeptidase 0.323678
SYNPR synaptoporin 0.32351
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.323438
MUC16 mucin 16, cell surface associated 0.323107
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 0.322713
EPHX2 epoxide hydrolase 2, cytoplasmic 0.32197
PTK2B protein tyrosine kinase 2 beta 0.321706
JAG1 jagged 1 0.321619
PTRH2 peptidyl-tRNA hydrolase 2 0.320625
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.320318
PICALM phosphatidylinositol binding clathrin assembly protein 0.319329
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.318759
HDLBP high density lipoprotein binding protein 0.317491
UNC13C unc-13 homolog C (C. elegans) 0.317317
COG6 component of oligomeric golgi complex 6 0.317144
KIAA1217 KIAA1217 0.316802
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.315337
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.315026
ATP9A ATPase, class II, type 9A 0.314872
FOXK2 forkhead box K2 0.31383
ERLEC1 endoplasmic reticulum lectin 1 0.313259
DLC1 DLC1 Rho GTPase activating protein 0.313119
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.312705
LOC100507377 uncharacterized LOC100507377 0.311902
AKAP2 A kinase (PRKA) anchor protein 2 0.311772
SEZ6L seizure related 6 homolog (mouse)-like 0.311386
ADCY2 adenylate cyclase 2 (brain) 0.310392
ESRRG estrogen-related receptor gamma 0.309915
LRRK2 leucine-rich repeat kinase 2 0.30968
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.30922
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.309106
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.308223
EGFL6 EGF-like-domain, multiple 6 0.308223
LEKR1 leucine, glutamate and lysine rich 1 0.308009
TLK1 tousled-like kinase 1 0.307691
BTG4 B-cell translocation gene 4 0.307483
NIPAL1 NIPA-like domain containing 1 0.307174
KDM5A lysine (K)-specific demethylase 5A 0.30627
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.30627
PSD3 pleckstrin and Sec7 domain containing 3 0.306151
LOC100134391 uncharacterized LOC100134391 0.305453
DSCC1 DNA replication and sister chromatid cohesion 1 0.305338
GLIS3 GLIS family zinc finger 3 0.304887
SNX24 sorting nexin 24 0.304775
FAM155A family with sequence similarity 155, member A 0.303164
CERS2 ceramide synthase 2 0.302551
PAIP2B poly(A) binding protein interacting protein 2B 0.301661
LINC00316 long intergenic non-protein coding RNA 316 0.300805
CDH13 cadherin 13 0.30007
RASGEF1A RasGEF domain family, member 1A 0.299801
FREM1 FRAS1 related extracellular matrix 1 0.299623
GALK2 galactokinase 2 0.299271
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.298166
BCAS4 breast carcinoma amplified sequence 4 0.297836
MLIP muscular LMNA-interacting protein 0.297512
CTPS2 CTP synthase 2 0.297431
LDB3 LIM domain binding 3 0.297351
SIRPA signal-regulatory protein alpha 0.297271
CNTN1 contactin 1 0.29672
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 0.296488
ZBTB16 zinc finger and BTB domain containing 16 0.296258
ANXA10 annexin A10 0.296106
SMAD7 SMAD family member 7 0.295289
BPIFC BPI fold containing family C 0.295217
CAMKMT calmodulin-lysine N-methyltransferase 0.294856
PAX3 paired box 3 0.294856
MED12L mediator complex subunit 12-like 0.294501
ARID1B AT rich interactive domain 1B (SWI1-like) 0.294291
BSN bassoon presynaptic cytomatrix protein 0.294291
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.294152
EDA ectodysplasin A 0.294083
LOC145845 uncharacterized LOC145845 0.294014
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.293945
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.293336
LINGO2 leucine rich repeat and Ig domain containing 2 0.29307
NTN1 netrin 1 0.29307
OSMR oncostatin M receptor 0.292939
FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 0.292678
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.291976
TBC1D7 TBC1 domain family, member 7 0.291727
ASB1 ankyrin repeat and SOCS box containing 1 0.291603
LAYN layilin 0.291603
LONRF3 LON peptidase N-terminal domain and ring finger 3 0.29148
LPO lactoperoxidase 0.29148
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 0.291357
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.291175
CLEC7A C-type lectin domain family 7, member A 0.291175
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.291054
AFAP1L1 actin filament associated protein 1-like 1 0.290755
LOC349160 uncharacterized LOC349160 0.29046
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.290227
LOC284788 uncharacterized LOC284788 0.290169
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.290111
ZNF423 zinc finger protein 423 0.289996
MPO myeloperoxidase 0.28943
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.289374
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.289042
RBMS1 RNA binding motif, single stranded interacting protein 1 0.288932
LHFPL3 lipoma HMGIC fusion partner-like 3 0.288823
GLP2R glucagon-like peptide 2 receptor 0.287969
SNTG2 syntrophin, gamma 2 0.28735
CNTN5 contactin 5 0.28735
THSD4 thrombospondin, type I, domain containing 4 0.287249
CMIP c-Maf inducing protein 0.287249
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.287098
CA10 carbonic anhydrase X 0.286503
TRAK1 trafficking protein, kinesin binding 1 0.286454
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.286211
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.285781
KCNIP4 Kv channel interacting protein 4 0.285546
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.285499
RPS15A ribosomal protein S15a 0.285313
FAM179B family with sequence similarity 179, member B 0.285313
NAV2 neuron navigator 2 0.285267
TRAM2 translocation associated membrane protein 2 0.285128
BCAS1 breast carcinoma amplified sequence 1 0.285037
FAM124B family with sequence similarity 124B 0.284629
SPAG16 sperm associated antigen 16 0.284539
C12ORF42 chromosome 12 open reading frame 42 0.284229
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.284138
OSBPL10 oxysterol binding protein-like 10 0.283976
PDGFRL platelet-derived growth factor receptor-like 0.283762
TENM2 teneurin transmembrane protein 2 0.283656
MEF2C myocyte enhancer factor 2C 0.283497
DGKB diacylglycerol kinase, beta 90kDa 0.283497
CAPS2 calcyphosine 2 0.282923
CLEC4A C-type lectin domain family 4, member A 0.282769
VILL villin-like 0.282412
MAST4 microtubule associated serine/threonine kinase family member 4 0.282361
AGR3 anterior gradient 3 0.28221
ANO7 anoctamin 7 0.281664
SEPT2 septin 2 0.281468
VWA8 von Willebrand factor A domain containing 8 0.28137
PCLO piccolo presynaptic cytomatrix protein 0.28084
ADGRF3 adhesion G protein-coupled receptor F3 0.280745
ARHGAP15 Rho GTPase activating protein 15 0.28065
COL23A1 collagen, type XXIII, alpha 1 0.280415
FHOD3 formin homology 2 domain containing 3 0.280368
LINC01588 long intergenic non-protein coding RNA 1588 0.27972
DNAI2 dynein, axonemal, intermediate chain 2 0.279584
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.279538
MDN1 MDN1, midasin homolog (yeast) 0.279403
GALM galactose mutarotase (aldose 1-epimerase) 0.279357
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 0.279178
ZDHHC14 zinc finger, DHHC-type containing 14 0.278472
DLG2 discs, large homolog 2 (Drosophila) 0.278385
CLECL1 C-type lectin-like 1 0.278298
LOC100288181 uncharacterized LOC100288181 0.278212
RELN reelin 0.277954
SH3GL2 SH3-domain GRB2-like 2 0.277869
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 0.277742
GAS6 growth arrest-specific 6 0.277531
SGMS1 sphingomyelin synthase 1 0.277197
ANO4 anoctamin 4 0.277197
HDAC9 histone deacetylase 9 0.277032
CCDC12 coiled-coil domain containing 12 0.277032
ANXA9 annexin A9 0.277032
AKAP6 A kinase (PRKA) anchor protein 6 0.277032
ESRRB estrogen-related receptor beta 0.276582
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 0.27618
KLHL3 kelch-like family member 3 0.276101
MACROD2 MACRO domain containing 2 0.276021
LOC100506446 uncharacterized LOC100506446 0.275667
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.275667
FGF14 fibroblast growth factor 14 0.275628
ZNF816 zinc finger protein 816 0.27555
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.275511
SLC35F1 solute carrier family 35, member F1 0.275472
CFAP58 cilia and flagella associated protein 58 0.275356
STK31 serine/threonine kinase 31 0.275241
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.275049
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.274973
GORASP2 golgi reassembly stacking protein 2, 55kDa 0.274897
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 0.274897
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 0.274783
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.274558
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.27452
COL6A2 collagen, type VI, alpha 2 0.274445
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.274334
NTM neurotrimin 0.274186
MTUS2 microtubule associated tumor suppressor candidate 2 0.274112
TSHZ2 teashirt zinc finger homeobox 2 0.27371
MORN5 MORN repeat containing 5 0.273602
CLSTN2 calsyntenin 2 0.27353
SH3TC2 SH3 domain and tetratricopeptide repeats 2 0.273386
VWC2L von Willebrand factor C domain containing protein 2-like 0.273386
ZNF681 zinc finger protein 681 0.273208
GLG1 golgi glycoprotein 1 0.273101
PUM1 pumilio RNA-binding family member 1 0.273066
CNTNAP2 contactin associated protein-like 2 0.27282
LINC00583 long intergenic non-protein coding RNA 583 0.272715
AMPD3 adenosine monophosphate deaminase 3 0.272472
RHOA ras homolog family member A 0.272369
EXOC4 exocyst complex component 4 0.272334
AKAP13 A kinase (PRKA) anchor protein 13 0.272334
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.2723
FAM19A4 family with sequence similarity 19 (chemokine (C-C motif)-like), member A4 0.2723
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.272061
ADD1 adducin 1 (alpha) 0.271959
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.271858
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.271858
AFF3 AF4/FMR2 family, member 3 0.271423
LPP LIM domain containing preferred translocation partner in lipoma 0.271423
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.271357
RAB3C RAB3C, member RAS oncogene family 0.27129
LINC01550 long intergenic non-protein coding RNA 1550 0.271258
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.271225
ATRNL1 attractin-like 1 0.271192
CCDC146 coiled-coil domain containing 146 0.271192
SECISBP2L SECIS binding protein 2-like 0.271159
ZNF365 zinc finger protein 365 0.270833
KDM4D lysine (K)-specific demethylase 4D 0.270575
ACVR1 activin A receptor, type I 0.270575
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.270575
RBM45 RNA binding motif protein 45 0.270511
PRKCH protein kinase C, eta 0.270383
SPPL3 signal peptide peptidase like 3 0.270256
ROR2 receptor tyrosine kinase-like orphan receptor 2 0.270161
EPB41 erythrocyte membrane protein band 4.1 0.270129
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 0.270066
TSPAN9 tetraspanin 9 0.269941
ADGRG1 adhesion G protein-coupled receptor G1 0.269941
SYK spleen tyrosine kinase 0.26991
SLC38A1 solute carrier family 38, member 1 0.269878
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2 0.269785
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 0.269723
SP100 SP100 nuclear antigen 0.269661
ZNF638 zinc finger protein 638 0.269599
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 0.269568
ACYP2 acylphosphatase 2, muscle type 0.269445
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.26911
TRDN triadin 0.26854
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.268481
CELF2 CUGBP, Elav-like family member 2 0.268393
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.268304
DOCK2 dedicator of cytokinesis 2 0.268216
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.268216
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 0.268071
DOK6 docking protein 6 0.267897
TTC39C tetratricopeptide repeat domain 39C 0.267897
CRTC3 CREB regulated transcription coactivator 3 0.267839
PCDH9 protocadherin 9 0.267753
KRT4 keratin 4, type II 0.267695
AGBL1 ATP/GTP binding protein-like 1 0.267666
DMD dystrophin 0.267638
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.267609
TEX14 testis expressed 14 0.267495
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 0.267467
FBN2 fibrillin 2 0.267269
SLC12A8 solute carrier family 12, member 8 0.266988
PRKCE protein kinase C, epsilon 0.266794
RCSD1 RCSD domain containing 1 0.266711
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 0.266629
GPC4 glypican 4 0.266601
MATN2 matrilin 2 0.266519
NRG1 neuregulin 1 0.266491
ANXA6 annexin A6 0.266382
DIO3 deiodinase, iodothyronine, type III 0.26622
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.266193
MRPL19 mitochondrial ribosomal protein L19 0.266166