ankylosing spondylitis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage. (Human Disease Ontology, DOID_7147)
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Genes

163 genes co-occuring with the disease ankylosing spondylitis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MRAP melanocortin 2 receptor accessory protein 2.97461
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.35614
ERAP1 endoplasmic reticulum aminopeptidase 1 2.0554
CRP C-reactive protein, pentraxin-related 1.88898
PHB2 prohibitin 2 1.77451
TNF tumor necrosis factor 1.6986
HLA-C major histocompatibility complex, class I, C 1.60323
CD79A CD79a molecule, immunoglobulin-associated alpha 1.46627
IL23R interleukin 23 receptor 1.31275
HLA-B major histocompatibility complex, class I, B 1.30794
HLA-E major histocompatibility complex, class I, E 1.22909
HLA-A major histocompatibility complex, class I, A 1.20007
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 1.17894
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 1.14009
CREG1 cellular repressor of E1A-stimulated genes 1 1.12909
ANTXR2 anthrax toxin receptor 2 1.08076
MMP3 matrix metallopeptidase 3 1.01976
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.986428
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa 0.946186
TAPBP TAP binding protein (tapasin) 0.906086
COL6A1 collagen, type VI, alpha 1 0.897872
ERAP2 endoplasmic reticulum aminopeptidase 2 0.897051
ACAN aggrecan 0.883521
IL1RN interleukin 1 receptor antagonist 0.876148
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 0.830689
BGLAP bone gamma-carboxyglutamate (gla) protein 0.829869
ANKH ANKH inorganic pyrophosphate transport regulator 0.825358
SOST sclerostin 0.794181
TBKBP1 TBK1 binding protein 1 0.783526
CD4 CD4 molecule 0.778613
CD80 CD80 molecule 0.774523
ALPL alkaline phosphatase, liver/bone/kidney 0.753306
MICA MHC class I polypeptide-related sequence A 0.749644
MEFV Mediterranean fever 0.741923
B2M beta-2-microglobulin 0.72329
DYNLT1 dynein, light chain, Tctex-type 1 0.718039
ALPPL2 alkaline phosphatase, placental-like 2 0.700722
ALPP alkaline phosphatase, placental 0.700321
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 0.698313
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.697109
FCHSD2 FCH and double SH3 domains 2 0.695504
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.687491
IL17A interleukin 17A 0.667152
JMY junction mediating and regulatory protein, p53 cofactor 0.6608
NCOA2 nuclear receptor coactivator 2 0.658026
KIF21B kinesin family member 21B 0.641827
HAPLN1 hyaluronan and proteoglycan link protein 1 0.63907
IL1R2 interleukin 1 receptor, type II 0.618268
PDCD1 programmed cell death 1 0.609276
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.608885
LYZ lysozyme 0.604591
IL6 interleukin 6 0.597961
HSPA1L heat shock 70kDa protein 1-like 0.591337
RPF1 ribosome production factor 1 homolog (S. cerevisiae) 0.586276
GPSM3 G-protein signaling modulator 3 0.58433
NOD2 nucleotide-binding oligomerization domain containing 2 0.57655
HIST1H2BM histone cluster 1, H2bm 0.56722
IL1B interleukin 1, beta 0.557509
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.552463
IL1A interleukin 1, alpha 0.548583
CARD9 caspase recruitment domain family, member 9 0.523045
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.508041
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.505356
GNL1 guanine nucleotide binding protein-like 1 0.50459
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.496175
ANO6 anoctamin 6 0.492359
KANK4 KN motif and ankyrin repeat domains 4 0.47753
TRIM45 tripartite motif containing 45 0.474119
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.459373
IL10 interleukin 10 0.450324
TLR4 toll-like receptor 4 0.416521
BMP2 bone morphogenetic protein 2 0.411657
SAA1 serum amyloid A1 0.407545
PADI4 peptidyl arginine deiminase, type IV 0.406798
C1R complement component 1, r subcomponent 0.406051
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.397098
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.393746
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.390769
CNOT3 CCR4-NOT transcription complex, subunit 3 0.372958
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 0.370737
SAA2 serum amyloid A2 0.365562
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.360764
IL23A interleukin 23, alpha subunit p19 0.355604
SFTPA1 surfactant protein A1 0.355235
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.351923
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 0.347144
E2F2 E2F transcription factor 2 0.342739
COMP cartilage oligomeric matrix protein 0.335778
HP haptoglobin 0.332852
BMP7 bone morphogenetic protein 7 0.3292
HPR haptoglobin-related protein 0.32701
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.324458
NKX2-3 NK2 homeobox 3 0.321909
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.318272
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.310652
TRADD TNFRSF1A-associated via death domain 0.301976
RUNX3 runt-related transcription factor 3 0.289027
IGLV9-49 immunoglobulin lambda variable 9-49 0.28831
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.287593
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.28616
CFDP1 craniofacial development protein 1 0.285802
PTH parathyroid hormone 0.285802
CCR6 chemokine (C-C motif) receptor 6 0.28294
VIPR1 vasoactive intestinal peptide receptor 1 0.282225
KLRC4 killer cell lectin-like receptor subfamily C, member 4 0.281153
KDM5A lysine (K)-specific demethylase 5A 0.279724
EPSTI1 epithelial stromal interaction 1 (breast) 0.27687
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.275801
BMP8A bone morphogenetic protein 8a 0.274376
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.273664
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.272597
SORBS1 sorbin and SH3 domain containing 1 0.266203
CD68 CD68 molecule 0.26514
MARK3 MAP/microtubule affinity-regulating kinase 3 0.264785
PADI1 peptidyl arginine deiminase, type I 0.264431
FCRL5 Fc receptor-like 5 0.261245
LTA lymphotoxin alpha 0.256652
RETN resistin 0.253831
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 0.252774
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.246448
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.244696
CA1 carbonic anhydrase I 0.238054
TREM1 triggering receptor expressed on myeloid cells 1 0.238054
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.233183
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 0.231102
CARD8 caspase recruitment domain family, member 8 0.228333
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 0.226607
TGFB1 transforming growth factor, beta 1 0.225917
CD69 CD69 molecule 0.214636
UEVLD UEV and lactate/malate dehyrogenase domains 0.213959
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 0.213959
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.208914
BTLA B and T lymphocyte associated 0.206248
CLIC1 chloride intracellular channel 1 0.20229
LRP6 low density lipoprotein receptor-related protein 6 0.200982
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.200006
FCAR Fc fragment of IgA receptor 0.199681
PLXNA2 plexin A2 0.196779
RGS6 regulator of G-protein signaling 6 0.1936
CTSK cathepsin K 0.192971
ARG2 arginase 2 0.190168
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 0.189244
MUC19 mucin 19, oligomeric 0.188938
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.188326
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 0.187719
ABHD16A abhydrolase domain containing 16A 0.183248
USP8 ubiquitin specific peptidase 8 0.18151
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma 0.181222
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.180367
OR2Y1 olfactory receptor, family 2, subfamily Y, member 1 0.180367
CROT carnitine O-octanoyltransferase 0.173571
PYDC1 PYD (pyrin domain) containing 1 0.173571
MSLNL mesothelin-like 0.173571
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.173057
ZPBP2 zona pellucida binding protein 2 0.172799
EDNRA endothelin receptor type A 0.171785
NCR3 natural cytotoxicity triggering receptor 3 0.168148
KREMEN1 kringle containing transmembrane protein 1 0.166768
B3GAT1 beta-1,3-glucuronyltransferase 1 0.164786
IBSP integrin-binding sialoprotein 0.161523
MT4 metallothionein 4 0.159302
GNG8 guanine nucleotide binding protein (G protein), gamma 8 0.158434
FCRL3 Fc receptor-like 3 0.157765