angle-closure glaucoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

115 genes co-occuring with the disease angle-closure glaucoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PLEKHA7 pleckstrin homology domain containing, family A member 7 2.16969
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2.12319
ST18 suppression of tumorigenicity 18, zinc finger 1.96098
COL11A1 collagen, type XI, alpha 1 1.58359
MFRP membrane frizzled-related protein 1.4733
CTSA cathepsin A 1.43771
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 1.3603
TMEM98 transmembrane protein 98 1.16992
BEST1 bestrophin 1 1.13247
CALCRL calcitonin receptor-like 1.0711
PDIA5 protein disulfide isomerase family A, member 5 1.06354
LOXL1 lysyl oxidase-like 1 1.05723
RAB22A RAB22A, member RAS oncogene family 1.01638
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.01638
LTBP3 latent transforming growth factor beta binding protein 3 0.967083
OPTN optineurin 0.94577
WDR36 WD repeat domain 36 0.945354
NTF4 neurotrophin 4 0.937044
LTBP2 latent transforming growth factor beta binding protein 2 0.926692
PYDC1 PYD (pyrin domain) containing 1 0.922149
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.770844
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.756564
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 0.754934
MFAP2 microfibrillar-associated protein 2 0.740705
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.725716
BIRC6 baculoviral IAP repeat containing 6 0.6939
MMP9 matrix metallopeptidase 9 0.693499
EYS eyes shut homolog (Drosophila) 0.686691
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.679499
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.677903
VAV2 vav 2 guanine nucleotide exchange factor 0.67312
FBLN2 fibulin 2 0.66199
MT-ATP8 ATP synthase F0 subunit 8 0.641433
FBN2 fibrillin 2 0.639857
LTBP1 latent transforming growth factor beta binding protein 1 0.638282
KRT12 keratin 12, type I 0.629242
VAV3 vav 3 guanine nucleotide exchange factor 0.61162
AQP7 aquaporin 7 0.6003
TGFB2 transforming growth factor, beta 2 0.593674
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) 0.591727
AXL AXL receptor tyrosine kinase 0.585108
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 0.581217
RHOA ras homolog family member A 0.552463
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.546256
HINT1 histidine triad nucleotide binding protein 1 0.546256
VSX2 visual system homeobox 2 0.538893
PEX19 peroxisomal biogenesis factor 19 0.522273
GJA1 gap junction protein, alpha 1, 43kDa 0.520731
RSPO1 R-spondin 1 0.512264
ASL argininosuccinate lyase 0.492359
SZRD1 SUZ RNA binding domain containing 1 0.490835
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 0.490072
SLC22A18 solute carrier family 22, member 18 0.488169
NLRP1 NLR family, pyrin domain containing 1 0.482844
TIMP1 TIMP metallopeptidase inhibitor 1 0.474119
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 0.459751
HPGDS hematopoietic prostaglandin D synthase 0.448817
GZMM granzyme M (lymphocyte met-ase 1) 0.42814
HPN hepsin 0.425514
ALPI alkaline phosphatase, intestinal 0.417644
DPT dermatopontin 0.405305
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.403811
TXNRD2 thioredoxin reductase 2 0.390025
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.384079
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 0.382594
NOS3 nitric oxide synthase 3 (endothelial cell) 0.378143
MMP1 matrix metallopeptidase 1 0.364085
PDE5A phosphodiesterase 5A, cGMP-specific 0.362239
GPR182 G protein-coupled receptor 182 0.360764
AQP5 aquaporin 5 0.35082
LOX lysyl oxidase 0.343473
GRM2 glutamate receptor, metabotropic 2 0.341639
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 0.338707
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.338707
EDN1 endothelin 1 0.331756
MMP2 matrix metallopeptidase 2 0.32701
FRZB frizzled-related protein 0.324823
FOXC1 forkhead box C1 0.320817
AQP3 aquaporin 3 (Gill blood group) 0.318272
GSTT1 glutathione S-transferase theta 1 0.313189
GSTTP1 glutathione S-transferase theta pseudogene 1 0.313189
LAMA3 laminin, alpha 3 0.301254
DNTT DNA nucleotidylexotransferase 0.299812
PITX2 paired-like homeodomain 2 0.295851
CRX cone-rod homeobox 0.285444
TIMP2 TIMP metallopeptidase inhibitor 2 0.272241
CSTB cystatin B (stefin B) 0.270819
GRM1 glutamate receptor, metabotropic 1 0.264785
FSCN2 fascin actin-bundling protein 2, retinal 0.257358
GSTM1 glutathione S-transferase mu 1 0.243295
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.215992
VCAN versican 0.206248
ELN elastin 0.206248
SFRP1 secreted frizzled-related protein 1 0.200331
GLS glutaminase 0.198386
RPE65 retinal pigment epithelium-specific protein 65kDa 0.195183
TGFB3 transforming growth factor, beta 3 0.192971
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.166995
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.161331
HSPA4 heat shock 70kDa protein 4 0.158266
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.143924
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.143727
NLRP3 NLR family, pyrin domain containing 3 0.143713
DNM2 dynamin 2 0.139304
ADM adrenomedullin 0.137037
AQP4 aquaporin 4 0.135758
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.13511
CARD17 caspase recruitment domain family, member 17 0.134792
PLAT plasminogen activator, tissue 0.13413
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.127178
F8 coagulation factor VIII, procoagulant component 0.122956
TLR4 toll-like receptor 4 0.122517
CRYAB crystallin, alpha B 0.122168
MNX1 motor neuron and pancreas homeobox 1 0.119186
TARDBP TAR DNA binding protein 0.118187