anemia Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells. (Human Disease Ontology, DOID_2355)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:2355
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Genes

220 genes associated with the disease anemia in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 2.48753
TTK TTK protein kinase 2.00881
ERAP1 endoplasmic reticulum aminopeptidase 1 1.98746
HK1 hexokinase 1 1.95321
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 1.88231
WNK1 WNK lysine deficient protein kinase 1 1.87603
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 1.87221
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 1.84623
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 1.82616
PDCD11 programmed cell death 11 1.80686
CALHM2 calcium homeostasis modulator 2 1.80686
SSR1 signal sequence receptor, alpha 1.79371
FAM57A family with sequence similarity 57, member A 1.79053
GEMIN4 gem (nuclear organelle) associated protein 4 1.79053
EBI3 Epstein-Barr virus induced 3 1.76324
PRCP prolylcarboxypeptidase (angiotensinase C) 1.69288
TMPRSS6 transmembrane protease, serine 6 1.67004
HFE hemochromatosis 1.65909
FN3KRP fructosamine 3 kinase related protein 1.47637
GCK glucokinase (hexokinase 4) 1.28564
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.14463
TF transferrin 1.0283
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.917276
PRKCE protein kinase C, epsilon 0.683763
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.62991
ANK1 ankyrin 1, erythrocytic 0.621333
G6PC2 glucose-6-phosphatase, catalytic, 2 0.510664
MYO9B myosin IXB 0.49221
SPTA1 spectrin, alpha, erythrocytic 1 0.484322
ATP11AUN ATP11A upstream neighbor 0.481235
CRIPT cysteine-rich PDZ-binding protein 0.477809
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 0.471705
MPST mercaptopyruvate sulfurtransferase 0.469233
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.466852
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 0.462836
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.461977
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 0.437241
SMAD1 SMAD family member 1 0.434468
SULT1C2P1 sulfotransferase family, cytosolic, 1C, member 2 pseudogene 1 0.426843
HPCAL1 hippocalcin-like 1 0.425463
ALX4 ALX homeobox 4 0.423344
C11ORF74 chromosome 11 open reading frame 74 0.417661
UBN1 ubinuclein 1 0.417386
MAEL maelstrom spermatogenic transposon silencer 0.417386
LOC643339 uncharacterized LOC643339 0.417131
PPL periplakin 0.416835
EPAS1 endothelial PAS domain protein 1 0.416745
PSD3 pleckstrin and Sec7 domain containing 3 0.416634
OCA2 oculocutaneous albinism II 0.416435
PNMA2 paraneoplastic Ma antigen 2 0.415816
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.414871
PDGFRL platelet-derived growth factor receptor-like 0.414526
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 0.411693
SDHAP3 succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3 0.411287
GYPC glycophorin C (Gerbich blood group) 0.411243
OLAH oleoyl-ACP hydrolase 0.410836
UNC13A unc-13 homolog A (C. elegans) 0.409569
CAMKMT calmodulin-lysine N-methyltransferase 0.40845
GRXCR1 glutaredoxin, cysteine rich 1 0.407856
CAB39L calcium binding protein 39-like 0.406111
GALNS galactosamine (N-acetyl)-6-sulfatase 0.405877
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 0.404761
ASPDH aspartate dehydrogenase domain containing 0.403523
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.402108
WDR7 WD repeat domain 7 0.402108
NUP35 nucleoporin 35kDa 0.401065
NFASC neurofascin 0.401065
PARVB parvin, beta 0.400981
PRDM16 PR domain containing 16 0.400328
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.399103
CEP128 centrosomal protein 128kDa 0.399029
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.398956
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.39874
UNQ6494 uncharacterized LOC100129066 0.398246
CSF3R colony stimulating factor 3 receptor (granulocyte) 0.397371
FSTL4 follistatin-like 4 0.397241
ARHGAP15 Rho GTPase activating protein 15 0.397112
PALLD palladin, cytoskeletal associated protein 0.396613
CHADL chondroadherin-like 0.39654
OTULIN OTU deubiquitinase with linear linkage specificity 0.396109
NOSTRIN nitric oxide synthase trafficking 0.395413
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.395277
L3MBTL2 l(3)mbt-like 2 (Drosophila) 0.394549
PACRG PARK2 co-regulated 0.394101
CSMD1 CUB and Sushi multiple domains 1 0.393481
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.392825
RGS21 regulator of G-protein signaling 21 0.391692
DUSP19 dual specificity phosphatase 19 0.391153
ASB2 ankyrin repeat and SOCS box containing 2 0.390682
DMRT1 doublesex and mab-3 related transcription factor 1 0.390426
MBNL2 muscleblind-like splicing regulator 2 0.390174
PCCA propionyl CoA carboxylase, alpha polypeptide 0.389876
DLG2 discs, large homolog 2 (Drosophila) 0.389535
MYO3B myosin IIIB 0.389343
LOC339529 uncharacterized LOC339529 0.389201
PHTF2 putative homeodomain transcription factor 2 0.388688
CD200R1 CD200 receptor 1 0.388551
EXT2 exostosin glycosyltransferase 2 0.387926
CLVS1 clavesin 1 0.386947
GRIK2 glutamate receptor, ionotropic, kainate 2 0.386701
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 0.38666
WNT3 wingless-type MMTV integration site family, member 3 0.386499
TRHDE thyrotropin-releasing hormone degrading enzyme 0.385789
CWC22 CWC22 spliceosome-associated protein 0.385483
OTX2-AS1 OTX2 antisense RNA 1 (head to head) 0.385446
CRTAC1 cartilage acidic protein 1 0.38522
MYRIP myosin VIIA and Rab interacting protein 0.38522
NRG3 neuregulin 3 0.384961
DAO D-amino-acid oxidase 0.384019
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.383749
OSBPL6 oxysterol binding protein-like 6 0.383749
ZNF652 zinc finger protein 652 0.382964
MECOM MDS1 and EVI1 complex locus 0.382818
SERGEF secretion regulating guanine nucleotide exchange factor 0.38271
GLDC glycine dehydrogenase (decarboxylating) 0.382494
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 0.382176
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.381794
FAM134B family with sequence similarity 134, member B 0.381521
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.380922
NELL1 NEL-like 1 (chicken) 0.380309
ACVR1B activin A receptor, type IB 0.380026
OR2L13 olfactory receptor, family 2, subfamily L, member 13 0.379564
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.378907
FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 0.378819
NBEA neurobeachin 0.378615
CLSTN2 calsyntenin 2 0.377963
PTPRD protein tyrosine phosphatase, receptor type, D 0.377963
TNIK TRAF2 and NCK interacting kinase 0.377879
OTOG otogelin 0.377306
SLC16A9 solute carrier family 16, member 9 0.377119
NRIP1 nuclear receptor interacting protein 1 0.376802
DPYSL2 dihydropyrimidinase-like 2 0.376724
EPHA7 EPH receptor A7 0.37621
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 0.376134
WDR66 WD repeat domain 66 0.376034
NPM2 nucleophosmin/nucleoplasmin 2 0.375201
ARSB arylsulfatase B 0.374565
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.374473
FAM171A1 family with sequence similarity 171, member A1 0.374336
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) 0.373885
AVL9 AVL9 homolog (S. cerevisiase) 0.373863
EP300 E1A binding protein p300 0.373686
CTBP2 C-terminal binding protein 2 0.373686
HDAC4 histone deacetylase 4 0.373642
DGKB diacylglycerol kinase, beta 90kDa 0.373554
THSD4 thrombospondin, type I, domain containing 4 0.373488
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 0.37291
LINC00578 long intergenic non-protein coding RNA 578 0.372247
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 0.371885
CEP63 centrosomal protein 63kDa 0.371686
ANO6 anoctamin 6 0.371549
FBLN2 fibulin 2 0.37151
ASTN2 astrotactin 2 0.371335
GPC6 glypican 6 0.371296
FRMD4A FERM domain containing 4A 0.371104
LOC100507424 uncharacterized LOC100507424 0.371009
NRXN1 neurexin 1 0.37017
ATXN8OS ATXN8 opposite strand (non-protein coding) 0.369605
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.369056
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 0.367172
CCDC138 coiled-coil domain containing 138 0.367009
DUOXA1 dual oxidase maturation factor 1 0.367009
IQSEC3 IQ motif and Sec7 domain 3 0.364167
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.361341
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.360987
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.360754
IGF1R insulin-like growth factor 1 receptor 0.359854
DUOX2 dual oxidase 2 0.359312
FSTL5 follistatin-like 5 0.3591
GSDMC gasdermin C 0.35889
OSBPL5 oxysterol binding protein-like 5 0.35889
LTA lymphotoxin alpha 0.358174
GLIS3 GLIS family zinc finger 3 0.358174
MAP7 microtubule-associated protein 7 0.356061
KDM4B lysine (K)-specific demethylase 4B 0.354889
ZNF804B zinc finger protein 804B 0.354606
NT5DC3 5'-nucleotidase domain containing 3 0.354235
TMEM132D transmembrane protein 132D 0.353602
CDCP1 CUB domain containing protein 1 0.353602
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.353602
PDE4D phosphodiesterase 4D, cAMP-specific 0.352902
UBTD1 ubiquitin domain containing 1 0.352816
DAGLB diacylglycerol lipase, beta 0.352477
RAB27A RAB27A, member RAS oncogene family 0.351895
DEPDC1B DEP domain containing 1B 0.351652
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 0.351251
SLC45A2 solute carrier family 45, member 2 0.350474
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.349653
ISPD isoprenoid synthase domain containing 0.349653
ARL15 ADP-ribosylation factor-like 15 0.348515
SOCS5 suppressor of cytokine signaling 5 0.348308
FAM188B family with sequence similarity 188, member B 0.348172
FREM2 FRAS1 related extracellular matrix protein 2 0.34757
RPL34 ribosomal protein L34 0.346985
PDE7B phosphodiesterase 7B 0.345445
FAT3 FAT atypical cadherin 3 0.344862
FAM161A family with sequence similarity 161, member A 0.344294
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.344294
DTX3L deltex 3 like, E3 ubiquitin ligase 0.343527
CFH complement factor H 0.343313
FGFR2 fibroblast growth factor receptor 2 0.342479
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 0.342276
C5 complement component 5 0.341863
B3GAT2 beta-1,3-glucuronyltransferase 2 0.341515
ADRA1A adrenoceptor alpha 1A 0.340227
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.339583
RANGAP1 Ran GTPase activating protein 1 0.33932
PHF21B PHD finger protein 21B 0.338599
RYR2 ryanodine receptor 2 (cardiac) 0.338599
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.338599
DFNB31 deafness, autosomal recessive 31 0.338246
TLL1 tolloid-like 1 0.338147
ASRGL1 asparaginase like 1 0.337801
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.337704
SORD sorbitol dehydrogenase 0.337704
CDH22 cadherin 22, type 2 0.337655
TRAPPC9 trafficking protein particle complex 9 0.337509
POU2F3 POU class 2 homeobox 3 0.337173
MOV10L1 Mov10 RISC complex RNA helicase like 1 0.337173
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.336516