anemia due to reduced life span of red cells Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A type of anemia related to a reduction in the average life span of red blood cells in the peripheral circulation, which is normally around 120 days. (Human Phenotype Ontology, HP_0011895)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0011895
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Genes

89 genes associated with the anemia due to reduced life span of red cells phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
HBB hemoglobin, beta 1.93389
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 1.75456
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 1.57357
OR51B5 olfactory receptor, family 51, subfamily B, member 5 1.53202
OR51F1 olfactory receptor, family 51, subfamily F, member 1 (gene/pseudogene) 1.2331
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 1.02086
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.808951
WWOX WW domain containing oxidoreductase 0.734024
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 0.676552
OTUD3 OTU deubiquitinase 3 0.535303
OR51B6 olfactory receptor, family 51, subfamily B, member 6 0.533367
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.457612
CDH13 cadherin 13 0.443208
POMGNT2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) 0.430795
ZNF804A zinc finger protein 804A 0.424122
MCC mutated in colorectal cancers 0.424122
CDH9 cadherin 9, type 2 (T1-cadherin) 0.422328
ZBED9 zinc finger, BED-type containing 9 0.412939
PHEX phosphate regulating endopeptidase homolog, X-linked 0.410331
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.409736
PHACTR1 phosphatase and actin regulator 1 0.408956
HYKK hydroxylysine kinase 0.408813
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.408446
CDH26 cadherin 26 0.407192
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 0.406318
HK2 hexokinase 2 0.405368
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.405267
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 0.405267
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.404311
OR51E2 olfactory receptor, family 51, subfamily E, member 2 0.403982
NLGN4X neuroligin 4, X-linked 0.403285
MAST2 microtubule associated serine/threonine kinase 2 0.401847
BMPR1A bone morphogenetic protein receptor, type IA 0.401543
MAP2K5 mitogen-activated protein kinase kinase 5 0.401445
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.401355
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 0.401355
IL17RD interleukin 17 receptor D 0.401355
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.401355
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.400586
PLXNA4 plexin A4 0.400586
SYCE3 synaptonemal complex central element protein 3 0.399242
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 0.399242
PRMT8 protein arginine methyltransferase 8 0.39918
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.398647
PARK2 parkin RBR E3 ubiquitin protein ligase 0.398647
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.398365
FAM53B family with sequence similarity 53, member B 0.397531
SPRED3 sprouty-related, EVH1 domain containing 3 0.397531
NRP1 neuropilin 1 0.397363
PPAP2B phosphatidic acid phosphatase type 2B 0.395421
MED27 mediator complex subunit 27 0.394692
PAX8 paired box 8 0.394172
ASUN asunder spermatogenesis regulator 0.393904
USP43 ubiquitin specific peptidase 43 0.393792
CIAPIN1 cytokine induced apoptosis inhibitor 1 0.393472
STON2 stonin 2 0.392247
MAML2 mastermind-like 2 (Drosophila) 0.392247
RAD51B RAD51 paralog B 0.392132
SVIL supervillin 0.392019
CSMD1 CUB and Sushi multiple domains 1 0.390413
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 0.389785
RNF220 ring finger protein 220 0.389694
MEIS1 Meis homeobox 1 0.389544
JAKMIP1 janus kinase and microtubule interacting protein 1 0.389544
MTMR10 myotubularin related protein 10 0.389544
KLHL33 kelch-like family member 33 0.389192
HNMT histamine N-methyltransferase 0.388964
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 0.38808
TSHZ2 teashirt zinc finger homeobox 2 0.387478
STAC SH3 and cysteine rich domain 0.387478
UROC1 urocanate hydratase 1 0.386933
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.386223
C14ORF132 chromosome 14 open reading frame 132 0.385781
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.385578
LOC643542 uncharacterized LOC643542 0.384798
OR13D1 olfactory receptor, family 13, subfamily D, member 1 0.383501
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.382064
ACAN aggrecan 0.381863
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.381863
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.380899
LOC648987 uncharacterized LOC648987 0.380533
RYR2 ryanodine receptor 2 (cardiac) 0.37983
ZNF329 zinc finger protein 329 0.37983
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.379327
OPCML opioid binding protein/cell adhesion molecule-like 0.379002
LOC400927 TPTE and PTEN homologous inositol lipid phosphatase pseudogene 0.378843
LINC01587 long intergenic non-protein coding RNA 1587 0.378685
DCLK1 doublecortin-like kinase 1 0.37749
DEPTOR DEP domain containing MTOR-interacting protein 0.375284