amyotrophic lateral sclerosis Gene Set

Dataset KEGG Pathways
Category structural or functional annotations
Type pathway
Description A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts (MeSH).|An autosomal dominant inherited form of amyloidosis.|A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94) (Experimental Factor Ontology, EFO_0000253)
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19 proteins participating in the amyotrophic lateral sclerosis pathway from the KEGG Pathways dataset.

Symbol Name
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
CAT catalase
CCS copper chaperone for superoxide dismutase
GPX1 glutathione peroxidase 1
KARS lysyl-tRNA synthetase
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
RAB5A RAB5A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SOD1 superoxide dismutase 1, soluble
SSR4 signal sequence receptor, delta
TP53 tumor protein p53