amyotrophic lateral sclerosis Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing. (Human Disease Ontology, DOID_332)
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Genes

108 genes associated with the disease amyotrophic lateral sclerosis in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14
AGBL4 ATP/GTP binding protein-like 4
AKAP13 A kinase (PRKA) anchor protein 13
ALAD aminolevulinate dehydratase
ANG angiogenin, ribonuclease, RNase A family, 5
APOE apolipoprotein E
ARSG arylsulfatase G
ATXN1 ataxin 1
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BCAS1 breast carcinoma amplified sequence 1
BTBD11 BTB (POZ) domain containing 11
C7ORF57 chromosome 7 open reading frame 57
C9ORF72 chromosome 9 open reading frame 72
CD1E CD1e molecule
CDC42 cell division cycle 42
CDC5L cell division cycle 5-like
CHAMP1 chromosome alignment maintaining phosphoprotein 1
CNTN4 contactin 4
CSNK1G3 casein kinase 1, gamma 3
CUBN cubilin (intrinsic factor-cobalamin receptor)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
DISC1 disrupted in schizophrenia 1
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DMD dystrophin
DPP6 dipeptidyl-peptidase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELF5 E74-like factor 5 (ets domain transcription factor)
EPO erythropoietin
FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
FGGY FGGY carbohydrate kinase domain containing
FHDC1 FH2 domain containing 1
FMN2 formin 2
FUS FUS RNA binding protein
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GUCD1 guanylyl cyclase domain containing 1
HFE hemochromatosis
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HUS1 HUS1 checkpoint homolog (S. pombe)
IFNK interferon, kappa
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INTS4 integrator complex subunit 4
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KCNIP4 Kv channel interacting protein 4
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0586 KIAA0586
KIFAP3 kinesin-associated protein 3
LAMA2 laminin, alpha 2
LIPC lipase, hepatic
MECOM MDS1 and EVI1 complex locus
MMP9 matrix metallopeptidase 9
MOB3B MOB kinase activator 3B
MORN2 MORN repeat containing 2
MPZL1 myelin protein zero-like 1
MYLIP myosin regulatory light chain interacting protein
NCAM2 neural cell adhesion molecule 2
NKRF NFKB repressing factor
NT5C1A 5'-nucleotidase, cytosolic IA
OTOA otoancorin
PDE10A phosphodiesterase 10A
PDE4B phosphodiesterase 4B, cAMP-specific
PEX11A peroxisomal biogenesis factor 11 alpha
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
POF1B premature ovarian failure, 1B
PON1 paraoxonase 1
PON2 paraoxonase 2
PON3 paraoxonase 3
PSEN1 presenilin 1
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RBMS2 RNA binding motif, single stranded interacting protein 2
RD3 retinal degeneration 3
RNF14 ring finger protein 14
RNF144A ring finger protein 144A
RUFY1 RUN and FYVE domain containing 1
SCN7A sodium channel, voltage gated, type VII alpha subunit
SELL selectin L
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SHB Src homology 2 domain containing adaptor protein B
SHROOM3 shroom family member 3
SIPA1L2 signal-induced proliferation-associated 1 like 2
SLC39A11 solute carrier family 39, member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMN1 survival of motor neuron 1, telomeric
SMN2 survival of motor neuron 2, centromeric
SOD1 superoxide dismutase 1, soluble
SPTB spectrin, beta, erythrocytic
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SSPO SCO-spondin
STAG2 stromal antigen 2
SUN3 Sad1 and UNC84 domain containing 3
SUSD1 sushi domain containing 1
TARDBP TAR DNA binding protein
TCEA1 transcription elongation factor A (SII), 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TNF tumor necrosis factor
UNC13A unc-13 homolog A (C. elegans)
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VCP valosin containing protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDR93 WD repeat domain 93
ZFP64 ZFP64 zinc finger protein
ZNF385B zinc finger protein 385B
ZNF746 zinc finger protein 746