amyotrophic lateral sclerosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing. (Human Disease Ontology, DOID_332)
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Genes

565 genes co-occuring with the disease amyotrophic lateral sclerosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 3.17797
TARDBP TAR DNA binding protein 3.0029
C9ORF72 chromosome 9 open reading frame 72 2.73143
FUS FUS RNA binding protein 2.67794
SOD1 superoxide dismutase 1, soluble 2.50445
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 2.29411
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 2.10233
UBQLN2 ubiquilin 2 2.01386
OPTN optineurin 1.80066
VCP valosin containing protein 1.77857
ATXN2 ataxin 2 1.76321
CNTF ciliary neurotrophic factor 1.69542
DCTN1 dynactin 1 1.67864
GDNF glial cell derived neurotrophic factor 1.6624
ANG angiogenin, ribonuclease, RNase A family, 5 1.63321
GRN granulin 1.55734
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 1.53833
NEFH neurofilament, heavy polypeptide 1.53568
BDNF brain-derived neurotrophic factor 1.48911
CHAT choline O-acetyltransferase 1.43859
SETX senataxin 1.43727
KIFAP3 kinesin-associated protein 3 1.41621
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 1.40745
DPP6 dipeptidyl-peptidase 6 1.38909
SQSTM1 sequestosome 1 1.38123
CDK5 cyclin-dependent kinase 5 1.3773
CHMP2B charged multivesicular body protein 2B 1.36902
GPR162 G protein-coupled receptor 162 1.36291
UNC13A unc-13 homolog A (C. elegans) 1.32978
FIG4 FIG4 phosphoinositide 5-phosphatase 1.3241
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 1.31537
RTN4 reticulon 4 1.30226
MAPT microtubule-associated protein tau 1.30183
ZNF512B zinc finger protein 512B 1.27344
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 1.26603
NGF nerve growth factor (beta polypeptide) 1.20829
NEFM neurofilament, medium polypeptide 1.20742
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.20699
GFAP glial fibrillary acidic protein 1.19489
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 1.18195
IGF1 insulin-like growth factor 1 (somatomedin C) 1.1635
SMN2 survival of motor neuron 2, centromeric 1.15283
TRH thyrotropin-releasing hormone 1.14772
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.12698
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 1.12361
AIF1 allograft inflammatory factor 1 1.10846
CST7 cystatin F (leukocystatin) 1.10678
TMEM106B transmembrane protein 106B 1.10048
HSPA4 heat shock 70kDa protein 4 1.07068
PVALB parvalbumin 1.06228
GLG1 golgi glycoprotein 1 1.06186
CALB1 calbindin 1, 28kDa 1.05934
SIGMAR1 sigma non-opioid intracellular receptor 1 1.05807
HTT huntingtin 1.05009
CCS copper chaperone for superoxide dismutase 1.03788
SMN1 survival of motor neuron 1, telomeric 1.02861
BTBD10 BTB (POZ) domain containing 10 1.02313
LMNB1 lamin B1 1.02271
DNAH12 dynein, axonemal, heavy chain 12 1.01723
DNAH14 dynein, axonemal, heavy chain 14 1.01723
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 1.00921
HSF1 heat shock transcription factor 1 1.00119
GRM5 glutamate receptor, metabotropic 5 0.995283
ELP3 elongator acetyltransferase complex subunit 3 0.987271
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.977585
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.964567
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.963728
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.948685
DAO D-amino-acid oxidase 0.941611
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.936629
NFE2L2 nuclear factor, erythroid 2-like 2 0.927105
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.926279
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.920085
NOP56 NOP56 ribonucleoprotein 0.917611
COL19A1 collagen, type XIX, alpha 1 0.900335
CST3 cystatin C 0.898282
GRM1 glutamate receptor, metabotropic 1 0.897461
AR androgen receptor 0.89623
NTF4 neurotrophin 4 0.893769
NTF3 neurotrophin 3 0.892538
FGGY FGGY carbohydrate kinase domain containing 0.892129
MNX1 motor neuron and pancreas homeobox 1 0.889668
VAC14 Vac14 homolog (S. cerevisiae) 0.882292
DNAH9 dynein, axonemal, heavy chain 9 0.882292
TNPO1 transportin 1 0.877786
PFN1 profilin 1 0.873691
RRM2 ribonucleotide reductase M2 0.86059
NGFR nerve growth factor receptor 0.857724
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.852402
IFT74 intraflagellar transport 74 0.841344
ATF3 activating transcription factor 3 0.81018
MGAM maltase-glucoamylase 0.808539
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.803616
ALS2CL ALS2 C-terminal like 0.802795
SRR serine racemase 0.801974
HMOX1 heme oxygenase 1 0.797872
ZNF699 zinc finger protein 699 0.794181
CNTFR ciliary neurotrophic factor receptor 0.791311
DNAH5 dynein, axonemal, heavy chain 5 0.784755
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 0.783116
UBQLN1 ubiquilin 1 0.782298
PABPC1 poly(A) binding protein, cytoplasmic 1 0.774523
HDAC6 histone deacetylase 6 0.767985
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.763494
UBN1 ubinuclein 1 0.760231
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.757786
C7ORF57 chromosome 7 open reading frame 57 0.756971
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae) 0.756971
DES desmin 0.74761
NAIP NLR family, apoptosis inhibitory protein 0.745985
C20ORF194 chromosome 20 open reading frame 194 0.736649
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 0.734622
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.729357
PRR32 proline rich 32 0.726929
VEGFA vascular endothelial growth factor A 0.725716
EWSR1 EWS RNA-binding protein 1 0.725311
P4HB prolyl 4-hydroxylase, beta polypeptide 0.724502
MAOB monoamine oxidase B 0.722482
SIRT1 sirtuin 1 0.721673
HSPB8 heat shock 22kDa protein 8 0.72127
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.716425
DCTN2 dynactin 2 (p50) 0.716021
CRYAB crystallin, alpha B 0.710378
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.705547
GPX4 glutathione peroxidase 4 0.699919
CHODL chondrolectin 0.698313
CA13 carbonic anhydrase XIII 0.697109
INA internexin neuronal intermediate filament protein, alpha 0.695905
IDI2 isopentenyl-diphosphate delta isomerase 2 0.692697
PON1 paraoxonase 1 0.692697
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.692296
CARD17 caspase recruitment domain family, member 17 0.691495
TMOD2 tropomodulin 2 (neuronal) 0.687891
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.686291
MOB3B MOB kinase activator 3B 0.685491
NES nestin 0.685091
GPX5 glutathione peroxidase 5 0.684692
GPX1 glutathione peroxidase 1 0.684692
RMDN3 regulator of microtubule dynamics 3 0.683493
DERL1 derlin 1 0.681495
KEAP1 kelch-like ECH-associated protein 1 0.679898
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 0.677504
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.668345
HSPA8 heat shock 70kDa protein 8 0.666358
CAMK1G calcium/calmodulin-dependent protein kinase IG 0.656441
SPG11 spastic paraplegia 11 (autosomal recessive) 0.649323
BBS2 Bardet-Biedl syndrome 2 0.644586
SYP synaptophysin 0.641039
MCHR1 melanin-concentrating hormone receptor 1 0.638282
ZNF704 zinc finger protein 704 0.637495
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.635135
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.633563
TNF tumor necrosis factor 0.630813
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.630813
CAT catalase 0.620226
NRAP nebulin-related anchoring protein 0.620226
RBM45 RNA binding motif protein 45 0.610448
GLUL glutamate-ammonia ligase 0.609666
MFN1 mitofusin 1 0.609276
ELANE elastase, neutrophil expressed 0.608885
STRADB STE20-related kinase adaptor beta 0.604201
ACHE acetylcholinesterase (Yt blood group) 0.603811
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.60303
SIRT2 sirtuin 2 0.60186
RRAD Ras-related associated with diabetes 0.59952
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 0.598351
MT3 metallothionein 3 0.597961
TPPP3 tubulin polymerization-promoting protein family member 3 0.597181
PPIF peptidylprolyl isomerase F 0.595233
APOE apolipoprotein E 0.594454
CHGB chromogranin B 0.594064
CAMP cathelicidin antimicrobial peptide 0.592116
TPRKB TP53RK binding protein 0.58939
DCP1B decapping mRNA 1B 0.58939
CS citrate synthase 0.587444
KIF5B kinesin family member 5B 0.587444
TXN thioredoxin 0.586276
BICD2 bicaudal D homolog 2 (Drosophila) 0.585887
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 0.585497
CTRL chymotrypsin-like 0.582773
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.581217
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 0.579661
VGF VGF nerve growth factor inducible 0.577327
KIAA1551 KIAA1551 0.575772
FGF1 fibroblast growth factor 1 (acidic) 0.571884
MAP2 microtubule-associated protein 2 0.571495
CCL2 chemokine (C-C motif) ligand 2 0.568386
ISL1 ISL LIM homeobox 1 0.567997
PON2 paraoxonase 2 0.56722
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 0.566054
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.562558
HFE hemochromatosis 0.558674
KLHDC10 kelch domain containing 10 0.550134
NUP50P1 nucleoporin 50 pseudogene 1 0.547032
NUP50 nucleoporin 50kDa 0.547032
PPARG peroxisome proliferator-activated receptor gamma 0.543155
BAX BCL2-associated X protein 0.542379
PAIP1 poly(A) binding protein interacting protein 1 0.538893
RRM1 ribonucleotide reductase M1 0.538118
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.537344
CSNK1D casein kinase 1, delta 0.535409
GRM2 glutamate receptor, metabotropic 2 0.535022
HSPB1 heat shock 27kDa protein 1 0.535022
MAPK14 mitogen-activated protein kinase 14 0.534248
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.533475
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.531541
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.530768
NPS neuropeptide S 0.527676
IFNK interferon, kappa 0.521117
PICK1 protein interacting with PRKCA 1 0.519575
C14ORF177 chromosome 14 open reading frame 177 0.518034
KCNIP1 Kv channel interacting protein 1 0.515725
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 0.51534
LRRK2 leucine-rich repeat kinase 2 0.514956
CD68 CD68 molecule 0.513417
TH tyrosine hydroxylase 0.510344
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.509959
CALB2 calbindin 2 0.509192
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.500761
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.500379
BLCAP bladder cancer associated protein 0.500379
UBL5 ubiquitin-like 5 0.499997
DROSHA drosha, ribonuclease type III 0.499997
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.495029
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.494266
GRM4 glutamate receptor, metabotropic 4 0.49274
TREM2 triggering receptor expressed on myeloid cells 2 0.490454
TECPR2 tectonin beta-propeller repeat containing 2 0.489311
UBXN6 UBX domain protein 6 0.486646
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.485505
ADA adenosine deaminase 0.484744
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.481705
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.481325
ALG10 ALG10, alpha-1,2-glucosyltransferase 0.480945
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.476772
SUN3 Sad1 and UNC84 domain containing 3 0.474877
NR1H2 nuclear receptor subfamily 1, group H, member 2 0.474119
XBP1 X-box binding protein 1 0.474119
EPHB3 EPH receptor B3 0.472982
SNRPB2 small nuclear ribonucleoprotein polypeptide B 0.472225
TMOD4 tropomodulin 4 (muscle) 0.471846
MAG myelin associated glycoprotein 0.467684
ELAVL1 ELAV like RNA binding protein 1 0.463149
PARK2 parkin RBR E3 ubiquitin protein ligase 0.463149
ADAR adenosine deaminase, RNA-specific 0.462016
MMP9 matrix metallopeptidase 9 0.460129
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.458996
HDAC9 histone deacetylase 9 0.452208
MSTN myostatin 0.451078
ATXN3 ataxin 3 0.449947
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 0.449571
TNPO2 transportin 2 0.449571
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 0.447311
DBR1 debranching RNA lariats 1 0.4443
C1QB complement component 1, q subcomponent, B chain 0.443171
PGM3 phosphoglucomutase 3 0.44129
HSPA12A heat shock 70kDa protein 12A 0.440162
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 0.439786
CREBBP CREB binding protein 0.437906
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.433772
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.433021
GAN gigaxonin 0.43227
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.430393
GRIK1 glutamate receptor, ionotropic, kainate 1 0.42814
CRYM crystallin, mu 0.424389
SIRT5 sirtuin 5 0.42289
FXN frataxin 0.42289
MDH1 malate dehydrogenase 1, NAD (soluble) 0.422515
SLC52A3 solute carrier family 52 (riboflavin transporter), member 3 0.42139
MATR3 matrin 3 0.42139
SIRT3 sirtuin 3 0.421016
TRAK2 trafficking protein, kinesin binding 2 0.419142
CA3 carbonic anhydrase III 0.418394
TSSK6 testis-specific serine kinase 6 0.41727
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 0.416896
DNER delta/notch-like EGF repeat containing 0.414276
DNAH8 dynein, axonemal, heavy chain 8 0.414276
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.413153
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.411657
NGRN neugrin, neurite outgrowth associated 0.410535
FGF2 fibroblast growth factor 2 (basic) 0.407919
OLIG2 oligodendrocyte lineage transcription factor 2 0.406798
MARCH5 membrane-associated ring finger (C3HC4) 5 0.406798
WDFY1 WD repeat and FYVE domain containing 1 0.404931
SPAG8 sperm associated antigen 8 0.404557
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.403811
CYC1 cytochrome c-1 0.401199
NEUROG2 neurogenin 2 0.397471
TMBIM4 transmembrane BAX inhibitor motif containing 4 0.396725
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 0.396353
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.395235
KIF5A kinesin family member 5A 0.391885
NBEAL1 neurobeachin-like 1 0.390397
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 0.390397
UBE2I ubiquitin-conjugating enzyme E2I 0.390025
CREB1 cAMP responsive element binding protein 1 0.387794
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 0.385565
PKN3 protein kinase N3 0.385193
MYLK2 myosin light chain kinase 2 0.383708
TUBA4A tubulin, alpha 4a 0.380368
MYOD1 myogenic differentiation 1 0.379997
SCN7A sodium channel, voltage gated, type VII alpha subunit 0.378143
NOTUM notum pectinacetylesterase homolog (Drosophila) 0.377773
MBP myelin basic protein 0.377773
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 0.377773
AOX1 aldehyde oxidase 1 0.37629
MUSK muscle, skeletal, receptor tyrosine kinase 0.372958
FBP2 fructose-1,6-bisphosphatase 2 0.370368
BECN1 beclin 1, autophagy related 0.369628
TBL1X transducin (beta)-like 1X-linked 0.368149
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.36704
CHMP3 charged multivesicular body protein 3 0.366671
MAP4 microtubule-associated protein 4 0.366671
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.363716
FBXO32 F-box protein 32 0.363716
MYOG myogenin (myogenic factor 4) 0.361502
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.361502
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.360395
VDAC1 voltage-dependent anion channel 1 0.358183
CTSC cathepsin C 0.353395
GAP43 growth associated protein 43 0.351923
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.350084
EGR3 early growth response 3 0.349717
ALAD aminolevulinate dehydratase 0.346777
MFN2 mitofusin 2 0.346042
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.342006
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 0.341639
MYBPH myosin binding protein H 0.340539
TUBA1A tubulin, alpha 1a 0.340173
ABLIM1 actin binding LIM protein 1 0.338341
FKBP1A FK506 binding protein 1A, 12kDa 0.337975
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.336876
APP amyloid beta (A4) precursor protein 0.33651
S100A6 S100 calcium binding protein A6 0.333583
RBBP9 retinoblastoma binding protein 9 0.332121
DAXX death-domain associated protein 0.332121
TAC1 tachykinin, precursor 1 0.331756
PRMT8 protein arginine methyltransferase 8 0.331391
INHBE inhibin, beta E 0.331391
HDAC4 histone deacetylase 4 0.331025
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.329565
KIF20B kinesin family member 20B 0.3292
CAST calpastatin 0.32774
LIX1 Lix1 homolog (chicken) 0.326646
INS insulin 0.325916
FAF2 Fas associated factor family member 2 0.325552
MAP6 microtubule-associated protein 6 0.325552
PRMT1 protein arginine methyltransferase 1 0.324458
JUN jun proto-oncogene 0.324458
CD4 CD4 molecule 0.324458
TBL1Y transducin (beta)-like 1, Y-linked 0.324094
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.324094
PKN1 protein kinase N1 0.32373
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.321909
CBS cystathionine-beta-synthase 0.319726
XRN1 5'-3' exoribonuclease 1 0.317909
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.317909
SUSD2 sushi domain containing 2 0.315729
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.315729
GSR glutathione reductase 0.315003
BCL2L1 BCL2-like 1 0.313189
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 0.312464
EEA1 early endosome antigen 1 0.309928
GSS glutathione synthetase 0.309566
SHH sonic hedgehog 0.308842
CNTN4 contactin 4 0.30848
CDH22 cadherin 22, type 2 0.308118
TF transferrin 0.308118
IGFALS insulin-like growth factor binding protein, acid labile subunit 0.306672
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 0.304864
CCR2 chemokine (C-C motif) receptor 2 0.304503
DNM2 dynamin 2 0.304142
ESRRB estrogen-related receptor beta 0.303781
GLS glutaminase 0.302698
PTBP3 polypyrimidine tract binding protein 3 0.302337
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.301976
CTSH cathepsin H 0.300894
KIF17 kinesin family member 17 0.299812
PMP22 peripheral myelin protein 22 0.299812
IL6 interleukin 6 0.299812
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.298731
HCCS holocytochrome c synthase 0.296571
RAB29 RAB29, member RAS oncogene family 0.295851
BAG3 BCL2-associated athanogene 3 0.295851
ATN1 atrophin 1 0.295851
CTSB cathepsin B 0.291898
RNASEH2A ribonuclease H2, subunit A 0.290821
GCLC glutamate-cysteine ligase, catalytic subunit 0.287952
CP ceruloplasmin (ferroxidase) 0.287593
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.28616
CAPN15 calpain 15 0.285802
PRNP prion protein 0.285802
FZD1 frizzled class receptor 1 0.284371
GPR50 G protein-coupled receptor 50 0.282582
CCNC cyclin C 0.280439
FZD2 frizzled class receptor 2 0.280082
FTH1 ferritin, heavy polypeptide 1 0.280082
ALB albumin 0.279367
BANF2 barrier to autointegration factor 2 0.279011
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.277584
SESN3 sestrin 3 0.277584
LGALS1 lectin, galactoside-binding, soluble, 1 0.277227
TP53 tumor protein p53 0.276514
ATG14 autophagy related 14 0.275445
HSBP1 heat shock factor binding protein 1 0.275089
SIRT4 sirtuin 4 0.273664
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.273308
SORT1 sortilin 1 0.272597
NRTN neurturin 0.269753
ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) 0.269398
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.267977
SIRT7 sirtuin 7 0.265494
PKN2 protein kinase N2 0.26514
SH2B3 SH2B adaptor protein 3 0.263722
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.263368
RGS18 regulator of G-protein signaling 18 0.261599
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.260184
CA4 carbonic anhydrase IV 0.259477
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.25877
PRND prion protein 2 (dublet) 0.258064
CNR1 cannabinoid receptor 1 (brain) 0.257711
FNIP2 folliculin interacting protein 2 0.257358
MYF5 myogenic factor 5 0.257005
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 0.255241
FOLH1B folate hydrolase 1B 0.255241
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.255241
AQP4 aquaporin 4 0.254888
SPG20 spastic paraplegia 20 (Troyer syndrome) 0.254888
RFK riboflavin kinase 0.254183
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.253831
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 0.250663
VIP vasoactive intestinal peptide 0.24996
HEXA hexosaminidase A (alpha polypeptide) 0.249257
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.248203
FTL ferritin, light polypeptide 0.24715
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 0.246448
HOXC10 homeobox C10 0.245747
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2 0.245396
FNIP1 folliculin interacting protein 1 0.244696
PNPLA6 patatin-like phospholipase domain containing 6 0.244696
KARS lysyl-tRNA synthetase 0.243645
SPAST spastin 0.243295
SRSF2 serine/arginine-rich splicing factor 2 0.241895
ATF6 activating transcription factor 6 0.240148
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.238403
RHOT1 ras homolog family member T1 0.237357
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.237009
PINK1 PTEN induced putative kinase 1 0.236312
KIF1B kinesin family member 1B 0.234225
UXT ubiquitously-expressed, prefoldin-like chaperone 0.232836
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.232836
ACO2 aconitase 2, mitochondrial 0.231795
LHX3 LIM homeobox 3 0.231448
REG3G regenerating islet-derived 3 gamma 0.230755
MT1B metallothionein 1B 0.22937
MYO9A myosin IXA 0.22937
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.226952
SNORA29 small nucleolar RNA, H/ACA box 29 0.226607
ESYT1 extended synaptotagmin-like protein 1 0.225917
SDF4 stromal cell derived factor 4 0.225573
TFRC transferrin receptor 0.223853
EDAR ectodysplasin A receptor 0.223509
C10ORF2 chromosome 10 open reading frame 2 0.222479
PLEK pleckstrin 0.222479
MMP2 matrix metallopeptidase 2 0.220766
PON3 paraoxonase 3 0.220424
SNCG synuclein, gamma (breast cancer-specific protein 1) 0.220081
SIRT6 sirtuin 6 0.219398
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.217352
FGD1 FYVE, RhoGEF and PH domain containing 1 0.216672
RGPD1 RANBP2-like and GRIP domain containing 1 0.213621
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.213283
PLIN4 perilipin 4 0.212945
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.212945
JAG2 jagged 2 0.212271
MGLL monoglyceride lipase 0.211597
MYO6 myosin VI 0.211597
TXNL1 thioredoxin-like 1 0.211261
CHD6 chromodomain helicase DNA binding protein 6 0.210925
TMOD3 tropomodulin 3 (ubiquitous) 0.210925
FAM155B family with sequence similarity 155, member B 0.207578
SUMO3 small ubiquitin-like modifier 3 0.207245
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.206913
MSTO1 misato 1, mitochondrial distribution and morphology regulator 0.206913
CSN1S1 casein alpha s1 0.20658
IGFBP4 insulin-like growth factor binding protein 4 0.206248
RAB12 RAB12, member RAS oncogene family 0.205585
KIFC3 kinesin family member C3 0.205585
BCL2A1 BCL2-related protein A1 0.204923
OXR1 oxidation resistance 1 0.204263
SNX10 sorting nexin 10 0.202618
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.20229
ACTB actin, beta 0.201962
AMPH amphiphysin 0.201635
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.201308
GLRX glutaredoxin (thioltransferase) 0.200331
LGALS4 lectin, galactoside-binding, soluble, 4 0.199356
PRKX protein kinase, X-linked 0.19582
GPHN gephyrin 0.195501
SUMO2 small ubiquitin-like modifier 2 0.192344
BCHE butyrylcholinesterase 0.192344
SYPL1 synaptophysin-like 1 0.190786
CTSS cathepsin S 0.190476
RTN4R reticulon 4 receptor 0.189551
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.188938
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.187113
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 0.186811
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.18591
TTBK1 tau tubulin kinase 1 0.185612
ETF1 eukaryotic translation termination factor 1 0.185612
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.185612
CDK2 cyclin-dependent kinase 2 0.185313
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.18472
FOXO3 forkhead box O3 0.184424
PVR poliovirus receptor 0.183835
GSTO1 glutathione S-transferase omega 1 0.183541
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.182375
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.180652
SYT1 synaptotagmin I 0.180367
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.179239
ACTG1 actin gamma 1 0.177576
KPNB1 karyopherin (importin) beta 1 0.176485
KCNK4 potassium channel, two pore domain subfamily K, member 4 0.175947
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.175679
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.175411
IL1B interleukin 1, beta 0.174881
DDIT3 DNA-damage-inducible transcript 3 0.174617
HTRA2 HtrA serine peptidase 2 0.174354
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.173571
IDI1 isopentenyl-diphosphate delta isomerase 1 0.173057
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.173057
GLS2 glutaminase 2 (liver, mitochondrial) 0.172799
ATG12 autophagy related 12 0.172799
DNTT DNA nucleotidylexotransferase 0.171535
CGB7 chorionic gonadotropin, beta polypeptide 7 0.170789
ERLIN2 ER lipid raft associated 2 0.170789
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 0.170544
DMD dystrophin 0.170544
CGB5 chorionic gonadotropin, beta polypeptide 5 0.169812
BAG1 BCL2-associated athanogene 0.168617
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.168148
TTR transthyretin 0.167682
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 0.166995
TLR2 toll-like receptor 2 0.166319
NFIL3 nuclear factor, interleukin 3 regulated 0.165655
DICER1 dicer 1, ribonuclease type III 0.165217
GHRH growth hormone releasing hormone 0.164786
OPA1 optic atrophy 1 (autosomal dominant) 0.164149
IGHMBP2 immunoglobulin mu binding protein 2 0.163938
NTNG1 netrin G1 0.163938
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.163729
CD79A CD79a molecule, immunoglobulin-associated alpha 0.162109
TBC1D24 TBC1 domain family, member 24 0.161139
MT4 metallothionein 4 0.160574
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.160387
S100B S100 calcium binding protein B 0.160021
NONO non-POU domain containing, octamer-binding 0.159838
SCN3B sodium channel, voltage gated, type III beta subunit 0.159838
ATE1 arginyltransferase 1 0.159658
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.159658
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.159302
ENO1 enolase 1, (alpha) 0.159124
RSPO2 R-spondin 2 0.158778
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.157929
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.157602