amyotrophic lateral sclerosis Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing. (Human Disease Ontology, DOID_332)
Similar Terms
Downloads & Tools

Genes

48 genes associated with the disease amyotrophic lateral sclerosis in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SUSD2 sushi domain containing 2 0.602429
KIFAP3 kinesin-associated protein 3 0.486425
CAMK1G calcium/calmodulin-dependent protein kinase IG 0.464771
TIAM1 T-cell lymphoma invasion and metastasis 1 0.464771
ZNF746 zinc finger protein 746 0.449873
UNC13A unc-13 homolog A (C. elegans) 0.438544
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.4215
CENPV centromere protein V 0.345945
C9ORF72 chromosome 9 open reading frame 72 0.327313
KIAA0513 KIAA0513 0.311576
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 0.311576
STK36 serine/threonine kinase 36 0.297866
LAMA3 laminin, alpha 3 0.285417
C4ORF36 chromosome 4 open reading frame 36 0.264872
PPY2P pancreatic polypeptide 2, pseudogene 0.264872
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.256228
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 0.256228
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.256228
IFRD1 interferon-related developmental regulator 1 0.197766
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 0.15771
FOLH1B folate hydrolase 1B 0.15771
DPP6 dipeptidyl-peptidase 6 0.15771
CSNK1G3 casein kinase 1, gamma 3 0.15771
SELL selectin L 0.126165
ATXN1 ataxin 1 0.126165
C1ORF112 chromosome 1 open reading frame 112 0.126165
KDM4A lysine (K)-specific demethylase 4A 0.100789
CNOT2 CCR4-NOT transcription complex, subunit 2 0.100789
PTPRF protein tyrosine phosphatase, receptor type, F 0.100789
NRXN3 neurexin 3 0.080593
SCN7A sodium channel, voltage gated, type VII alpha subunit 0.064973
VIL1 villin 1 0.064973
CNTN4 contactin 4 0.064973
PCSK5 proprotein convertase subtilisin/kexin type 5 0.064973
CPNE4 copine IV 0.064973
OR52K3P olfactory receptor, family 52, subfamily K, member 3 pseudogene 0.064973
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.052255
NT5C1A 5'-nucleotidase, cytosolic IA 0.052255
MORN2 MORN repeat containing 2 0.052255
METTL15 methyltransferase like 15 0.052255
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.052255
DISC1 disrupted in schizophrenia 1 0.052255
SLC39A11 solute carrier family 39, member 11 0.052255
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 0.043246
RBMS1 RNA binding motif, single stranded interacting protein 1 0.043246
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 0.043246
MIR99AHG mir-99a-let-7c cluster host gene 0.043246
LIPC lipase, hepatic 0.043246