amyotrophic lateral sclerosis; Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing. (Human Disease Ontology, DOID_332)
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Genes

65 genes associated with the disease amyotrophic lateral sclerosis; in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ADD1 adducin 1 (alpha)
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
ANG angiogenin, ribonuclease, RNase A family, 5
ANK1 ankyrin 1, erythrocytic
APOA4 apolipoprotein A-IV
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
ARHGAP18 Rho GTPase activating protein 18
CETP cholesteryl ester transfer protein, plasma
CLNK cytokine-dependent hematopoietic cell linker
DCP1A decapping mRNA 1A
DPP6 dipeptidyl-peptidase 6
ELP3 elongator acetyltransferase complex subunit 3
EXOC4 exocyst complex component 4
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FBXO8 F-box protein 8
FGB fibrinogen beta chain
FGGY FGGY carbohydrate kinase domain containing
FUS FUS RNA binding protein
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GSTO1 glutathione S-transferase omega 1
GSTO2 glutathione S-transferase omega 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM1 intercellular adhesion molecule 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KIAA0226L KIAA0226-like
LDLR low density lipoprotein receptor
LIPC lipase, hepatic
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
LTA lymphotoxin alpha
MACROD2 MACRO domain containing 2
MAN1A2 mannosidase, alpha, class 1A, member 2
MMP3 matrix metallopeptidase 3
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NELL1 NEL-like 1 (chicken)
NLGN1 neuroligin 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
PON1 paraoxonase 1
PON2 paraoxonase 2
PON3 paraoxonase 3
PPARG peroxisome proliferator-activated receptor gamma
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELE selectin E
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHROOM3 shroom family member 3
SOD1 superoxide dismutase 1, soluble
SUSD1 sushi domain containing 1
TNF tumor necrosis factor
TXNRD1 thioredoxin reductase 1
UNC13A unc-13 homolog A (C. elegans)
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
ZFP64 ZFP64 zinc finger protein
ZNF519 zinc finger protein 519