amylocaine-4169 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the amylocaine-4169 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM29 ADAM metallopeptidase domain 29
ANKLE2 ankyrin repeat and LEM domain containing 2
AP3B2 adaptor-related protein complex 3, beta 2 subunit
AQP3 aquaporin 3 (Gill blood group)
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
C3ORF18 chromosome 3 open reading frame 18
C7ORF69 chromosome 7 open reading frame 69
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALCR calcitonin receptor
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CARTPT CART prepropeptide
CD4 CD4 molecule
CD84 CD84 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFAP69 cilia and flagella associated protein 69
CLEC2B C-type lectin domain family 2, member B
COL7A1 collagen, type VII, alpha 1
COL8A2 collagen, type VIII, alpha 2
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CREB5 cAMP responsive element binding protein 5
DCSTAMP dendrocyte expressed seven transmembrane protein
DRP2 dystrophin related protein 2
EDN1 endothelin 1
EMP1 epithelial membrane protein 1
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FHL1 four and a half LIM domains 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GBP1 guanylate binding protein 1, interferon-inducible
GH1 growth hormone 1
GM2A GM2 ganglioside activator
GPR1 G protein-coupled receptor 1
GRM8 glutamate receptor, metabotropic 8
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HSF1 heat shock transcription factor 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1R insulin-like growth factor 1 receptor
IGHA1 immunoglobulin heavy constant alpha 1
IGL immunoglobulin lambda locus
IL1RL1 interleukin 1 receptor-like 1
IL6R interleukin 6 receptor
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KLF6 Kruppel-like factor 6
KMT2A lysine (K)-specific methyltransferase 2A
LECT1 leukocyte cell derived chemotaxin 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MEF2C myocyte enhancer factor 2C
MEGF8 multiple EGF-like-domains 8
MIER2 mesoderm induction early response 1, family member 2
MPL MPL proto-oncogene, thrombopoietin receptor
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC6 mucin 6, oligomeric mucus/gel-forming
NCR2 natural cytotoxicity triggering receptor 2
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NTS neurotensin
NUP50 nucleoporin 50kDa
NUP88 nucleoporin 88kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAX5 paired box 5
PCDHB12 protocadherin beta 12
PDE10A phosphodiesterase 10A
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PML promyelocytic leukemia
PNPLA3 patatin-like phospholipase domain containing 3
PODNL1 podocan-like 1
PRDX2 peroxiredoxin 2
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PSCA prostate stem cell antigen
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PVR poliovirus receptor
RND2 Rho family GTPase 2
RUNX1 runt-related transcription factor 1
RXRB retinoid X receptor, beta
SCNN1B sodium channel, non voltage gated 1 beta subunit
SERHL2 serine hydrolase-like 2
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SPON1 spondin 1, extracellular matrix protein
SSX3 synovial sarcoma, X breakpoint 3
STK24 serine/threonine kinase 24
STS steroid sulfatase (microsomal), isozyme S
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYN3 synapsin III
TAAR5 trace amine associated receptor 5
TCF3 transcription factor 3
TFEB transcription factor EB
TM4SF1 transmembrane 4 L six family member 1
TNS1 tensin 1
TP63 tumor protein p63
TRIM3 tripartite motif containing 3
TUBBP5 tubulin, beta pseudogene 5
VIP vasoactive intestinal peptide
WISP3 WNT1 inducible signaling pathway protein 3
YY2 YY2 transcription factor
ZNF384 zinc finger protein 384
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADGRE1 adhesion G protein-coupled receptor E1
ADORA3 adenosine A3 receptor
AHNAK2 AHNAK nucleoprotein 2
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BARX2 BARX homeobox 2
BIRC7 baculoviral IAP repeat containing 7
C1ORF54 chromosome 1 open reading frame 54
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAPN15 calpain 15
CASC1 cancer susceptibility candidate 1
CCDC68 coiled-coil domain containing 68
CD53 CD53 molecule
CD82 CD82 molecule
CDK20 cyclin-dependent kinase 20
CFAP70 cilia and flagella associated protein 70
CNTN1 contactin 1
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CPB2 carboxypeptidase B2 (plasma)
CRY2 cryptochrome circadian clock 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DPY19L1P1 DPY19L1 pseudogene 1
DSPP dentin sialophosphoprotein
ELAVL2 ELAV like neuron-specific RNA binding protein 2
FAM212B family with sequence similarity 212, member B
FBXL7 F-box and leucine-rich repeat protein 7
FFAR2 free fatty acid receptor 2
FGF16 fibroblast growth factor 16
FLJ22184
FRMD1 FERM domain containing 1
FSCN3 fascin actin-bundling protein 3, testicular
G6PC2 glucose-6-phosphatase, catalytic, 2
GFI1 growth factor independent 1 transcription repressor
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GSTTP1 glutathione S-transferase theta pseudogene 1
HCG4 HLA complex group 4 (non-protein coding)
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HDAC11 histone deacetylase 11
HIST1H3F histone cluster 1, H3f
HIST2H2AA3 histone cluster 2, H2aa3
HMOX1 heme oxygenase 1
IGSF1 immunoglobulin superfamily, member 1
IL12RB1 interleukin 12 receptor, beta 1
INPP5J inositol polyphosphate-5-phosphatase J
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KDM8 lysine (K)-specific demethylase 8
KEL Kell blood group, metallo-endopeptidase
KIAA1024 KIAA1024
KIF13A kinesin family member 13A
KLF3 Kruppel-like factor 3 (basic)
KRT75 keratin 75, type II
LHX3 LIM homeobox 3
LIME1 Lck interacting transmembrane adaptor 1
LINC00597 long intergenic non-protein coding RNA 597
LOXL3 lysyl oxidase-like 3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MRPL41 mitochondrial ribosomal protein L41
MTCP1 mature T-cell proliferation 1
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NKX3-2 NK3 homeobox 2
NOL12 nucleolar protein 12
NPY4R neuropeptide Y receptor Y4
PAQR4 progestin and adipoQ receptor family member IV
PLA2G1B phospholipase A2, group IB (pancreas)
PLAC1 placenta-specific 1
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAB40C RAB40C, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF32 ring finger protein 32
SCML2 sex comb on midleg-like 2 (Drosophila)
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SNCAIP synuclein, alpha interacting protein
SNTA1 syntrophin, alpha 1
SNTG1 syntrophin, gamma 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAS2R4 taste receptor, type 2, member 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM68 tripartite motif containing 68
TSPAN9 tetraspanin 9
UNC93B1 unc-93 homolog B1 (C. elegans)
VASH2 vasohibin 2
ZBTB22 zinc finger and BTB domain containing 22
ZFHX4 zinc finger homeobox 4
ZNF16 zinc finger protein 16
ZNF230 zinc finger protein 230